Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to yellow green clear liquid (est) |
Assay: | 95.00 to 100.00 %
|
Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.12400 to 1.43500 @ 25.00 °C.
|
Pounds per Gallon - (est).: | 9.353 to 11.941
|
Refractive Index: | 1.53600 to 1.53800 @ 20.00 °C.
|
Melting Point: | 29.00 to 30.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 294.00 to 295.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 159.00 to 160.00 °C. @ 10.00 mm Hg
|
Vapor Pressure: | 0.003000 mmHg @ 25.00 °C. (est) |
Flash Point: | 243.00 °F. TCC ( 117.20 °C. ) (est)
|
logP (o/w): | 3.481 (est) |
Soluble in: |
| alcohol | | acetone | | ether | | acetic acid | | water, 27.68 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
|
Odor Type: herbal |
|
Odor Strength: | low |
|
| parsley herbal |
Odor Description: at 100.00 %. | parsley faint |
|
Odor and/or flavor descriptions from others (if found). |
|
|
Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
|
Hazards identification |
|
Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
|
Pictogram | |
|
Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
|
Dermal Toxicity: |
subcutaneous-frog LDLo 1515 mg/kg PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 35, Pg. 342, 1895.
subcutaneous-mouse LDLo 1000 mg/kg Bolletino della Societe Italiana di Biologia Sperimentale. Vol. 14, Pg. 291, 1939.
|
Inhalation Toxicity: |
Not determined
|
Safety in Use Information:
Category: | natural substances and extractives |
Recommendation for apiole (parsley) usage levels up to: | | not for fragrance use.
|
|
Recommendation for apiole (parsley) flavor usage levels up to: |
| not for flavor use.
|
Safety References:
EPI System: | View |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 523-80-8 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 10659 |
National Institute of Allergy and Infectious Diseases: | Data |
| 4,7-dimethoxy-5-prop-2-enyl-1,3-benzodioxole |
Chemidplus: | 0000523808 |
RTECS: | CY2500000 for cas# 523-80-8 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| allyl dimethoxymethylene dioxybenzene | 1- | allyl-2,5-dimethoxy-3,4-methylene dioxybenzene | 1- | allyl-2,5-dimethoxy-3,4-methylenedioxybenzene | 5- | allyl-4,7-dimethoxy-1,3-benzodioxol | | apiol (parsley) | | apioline (parsley) | 1,3- | benzodioxole, 4,7-dimethoxy-5-(2-propen-1-yl)- | 1,3- | benzodioxole, 4,7-dimethoxy-5-(2-propenyl)- | 4,7- | dimethoxy-5-(2-propenyl)-1,3-benzodioxole | 4,7- | dimethoxy-5-(prop-2-en-1-yl)-1,3-benzodioxole | 4,7- | dimethoxy-5-prop-2-enyl-1,3-benzodioxole | 4,7- | dimethoxy-5-prop-2-enyl-2H-benzo[d]1,3-dioxolene | 1,2- | methylene dioxy-3,6-dimethoxy-4-allyl benzene | | parsley apiol | | parsley apiole | | parsley camphor |
Articles:
PubMed: | The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate. |
PubMed: | Age-dependent changes from allylphenol to prenylated benzoic acid production in Piper gaudichaudianum Kunth. |
PubMed: | Chemical composition, antimicrobial and antioxidant activities of the essential oil of Psammogeton canescens. |
PubMed: | [Poisoning by apiole. 3. Toxicological studies: Labat reaction and determination with chromotropic acid]. |
PubMed: | [Poisoning by apiole. II. Histopathological aspects and pathogenetic discussion]. |
PubMed: | [Quantitative determination of apiole]. |
PubMed: | Psychotrophic phenylisopropylamines derived from apiole and dillapiole. |
PubMed: | Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells. |
PubMed: | Medicinal plants from the genus Acalypha (Euphorbiaceae)--a review of their ethnopharmacology and phytochemistry. |
PubMed: | Endemic Balkan parsnip Pastinaca hirsuta: the chemical profile of essential oils, headspace volatiles and extracts. |
PubMed: | Critique of medicinal conspicuousness of Parsley(Petroselinum crispum): a culinary herb of Mediterranean region. |
PubMed: | Chemical composition of the essential oil of Pituranthos scoparius. |
PubMed: | Chemical and biological evaluation of essential oils from two species of Myrtaceae - Eugenia uniflora L. and Plinia trunciflora (O. Berg) Kausel. |
PubMed: | Antioxidant capacity and larvicidal and antifungal activities of essential oils and extracts from Piper krukoffii. |
PubMed: | Acaricidal activities of apiol and its derivatives from Petroselinum sativum seeds against Dermatophagoides pteronyssinus, Dermatophagoides farinae, and Tyrophagus putrescentiae. |
PubMed: | Chemical composition and antioxidant activities of the essential oil and methanol extracts of Psammogeton canescens. |
PubMed: | Antimicrobial activities of essential oil and hexane extract of Florence fennel [Foeniculum vulgare var. azoricum (Mill.) Thell.] against foodborne microorganisms. |
PubMed: | Comparative essential oil composition of flowers, leavesand stems of basil (Ocimum basilicum L.) used as herb. |
PubMed: | Biotransformation of menthol and geraniol by hairy root cultures of Anethum graveolens: effect on growth and volatile components. |
PubMed: | Essential oil composition of three Peperomia species from the Amazon, Brazil. |
PubMed: | Chemical composition and antimicrobial activities of the essential oil from the seeds of Enterolobium contortisiliquum (leguminosae). |
PubMed: | Chemical composition and antimicrobial activity of Momordica charantia seed essential oil. |
PubMed: | Comparative analysis of the oil and supercritical CO2 extract of Ridolfia segetum (L.) Moris. |
PubMed: | Inhibition of oxidation of human low-density lipoproteins by phenolic substances in different essential oils varieties. |
PubMed: | Compartive study of volatile components and fatty acids of plants and in vitro cultures of parsley (Petroselinum crispum (Mill) nym ex hill). |
PubMed: | Volatile chemical constituents of Piper aduncum L and Piper gibbilimbum C. DC (Piperaceae) from Papua New Guinea. |
PubMed: | Dillapiol and Apiol as specific inhibitors of the biosynthesis of aflatoxin G1 in Aspergillus parasiticus. |
PubMed: | Plant-derived natural products exhibiting activity against formosan subterranean termites (Coptotermes formosanus). |
PubMed: | Enzyme activity in the flesh fly Parasarcophaga dux Thomson influenced by dill compounds, myristicin and apiol. |
PubMed: | Toxicological efficacy of some indigenous dill compounds against the flesh fly, Parasarcophaga dux Thomson. |
PubMed: | Anaerobic utilization of essential oils by denitrifying bacteria. |
|