T-cadinol
(1S,4S,4aR,8aR)-4-isopropyl-1,6-dimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-ol
 
Notes:
extract of scented myrrh. Constit. of Juniperus communis (juniper)
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CAS Number: 5937-11-1Picture of molecule3D/inchi
Nikkaji Web: J15.462H
XlogP3-AA: 3.30 (est)
Molecular Weight: 222.37142000
Formula: C15 H26 O
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Appearance: white crystalline solid (est)
Assay: 97.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 139.00 to  140.00 °C. @ 760.00 mm Hg
Boiling Point: 302.00 to  304.00 °C. @ 760.00 mm Hg
Flash Point: 263.00 °F. TCC ( 128.33 °C. )
logP (o/w): 4.899 (est)
Soluble in:
 alcohol
 water, 9.13 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
 
Odor Type: balsamic
 
Odor Strength: none
 
 balsamic  earthy  
Odor Description:
at 100.00 %. 
pure has no odor but mixtures have balsam earthy
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for T-cadinol usage levels up to:
  7.0000 % in the fragrance concentrate.
 
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 160799
National Institute of Allergy and Infectious Diseases: Data
 (1S,4S,4aR,8aR)-1,6-dimethyl-4-propan-2-yl-3,4,4a,7,8,8a-hexahydro-2H-naphthalen-1-ol
Chemidplus: 0005937111
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References:
 (1S,4S,4aR,8aR)-1,6-dimethyl-4-propan-2-yl-3,4,4a,7,8,8a-hexahydro-2H-naphthalen-1-ol
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 160799
Pubchem (sid): 135116958
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
HMDB (The Human Metabolome Database): HMDB36646
FooDB: FDB015571
Typical G.C.
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
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Potential Blenders and core components note
 
For Odor
No odor group found for these
(E)-sabinene hydrateFL/FR
anisic
para-anisyl phenyl acetateFL/FR
balsamic
siam benzoin absoluteFL/FR
siam benzoin resinoidFL/FR
1-benzoyl acetoneFL/FR
laevo-bornyl acetateFL/FR
 brachyleana hutchinsii wood oilFR
 conifer acetateFR
 fir needle oil canadaFL/FR
 fir needle oil terpeneless canadaFL/FR
 guaiyl butyrateFR
 hemlock western oil (tsuga heterophylla) canadaFR
 juniper berry absoluteFL/FR
 myrrh absoluteFL/FR
 myrrh resinoidFR
 tolu balsam absoluteFL/FR
 tolu balsam resinoidFL/FR
floral
 cananga oilFL/FR
 cananga oil chinaFL/FR
 rose absolute (rosa centifolia) moroccoFL/FR
green
 galbanum absoluteFL/FR
 galbanum oleoresinFL/FR
 galbanum resinoidFL/FR
 valerian rhizome oil CO2 extract chinaFL/FR
herbal
 canarium luzonicum gumFL/FR
 rosemary absoluteFL/FR
 rosemary oil moroccoFL/FR
 rosemary oil spainFL/FR
 valerian rhizome oilFL/FR
 valerian rhizome oil chinaFL/FR
spicy
 elettaria cardamomum seed oilFL/FR
 nutmeg absoluteFL/FR
terpenic
 elemi resinoidFL/FR
 pine needle oil dwarfFL/FR
woody
 copaiba balsamFL/FR
 guaiacwood oil 20% in gurjun balsam oilFR
alpha-guaieneFL/FR
 gurjun balsam oilFR
alpha-gurjuneneFR
4-hydroxybenzaldehydeFL/FR
 patchouli oilFL/FR
 sandalwood oilFL/FR
 sandalwood oil west australia (santalum spicatum)FR
 santalyl butyrateFL/FR
 vetiverolFL/FR
 
For Flavor
 
No flavor group found for these
1-benzoyl acetoneFL/FR
 fir needle oil canadaFL/FR
alpha-guaieneFL/FR
(E)-sabinene hydrateFL/FR
 santalyl butyrateFL/FR
anisic
para-anisyl phenyl acetateFL/FR
balsamic
siam benzoin resinoidFL/FR
laevo-bornyl acetateFL/FR
 fir needle oil terpeneless canadaFL/FR
 juniper berry absoluteFL/FR
 myrrh absoluteFL/FR
 peru balsamFL
 tolu balsam absoluteFL/FR
 tolu balsam resinoidFL/FR
creamy
4-hydroxybenzaldehydeFL/FR
floral
 cananga oilFL/FR
 cananga oil chinaFL/FR
 rose absolute (rosa centifolia) moroccoFL/FR
 valerian rhizome oilFL/FR
 valerian rhizome oil chinaFL/FR
 valerian rhizome oil CO2 extract chinaFL/FR
green
 canarium luzonicum gumFL/FR
 elemi resinoidFL/FR
 galbanum absoluteFL/FR
 galbanum oleoresinFL/FR
 galbanum resinoidFL/FR
herbal
 rosemary absoluteFL/FR
 rosemary oil moroccoFL/FR
 rosemary oil spainFL/FR
pine
 pine needle oil dwarfFL/FR
spicy
siam benzoin absoluteFL/FR
 elettaria cardamomum seed oilFL/FR
 galangal root oleoresinFL
 nutmeg absoluteFL/FR
woody
 copaiba balsamFL/FR
 patchouli oilFL/FR
 sandalwood oilFL/FR
 vetiverolFL/FR
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 amyris wood oil @ <0.10%
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 angelica root oil @ 0.04%
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 basil oil CO2 sweet @ 5.79%
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 basil oil sweet @ 18.14%
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 basil oil var. glabratum turkey @ 3.06%
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 basil plant
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 basil shoot oil
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 cajuput oil vietnam @ trace%
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 cananga leaf oil @ 0.9%
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 cascarilla bark oil @ 1.00%
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 cassinia laevis flower oil australia @ 2.50%
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 cassinia laevis leaf oil australia @ 0.10%
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 cinnamon fruit oil india @ 2.7-3.4%
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 curry fruit oil india @ 0.10%
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 curry leaf oil india @ 0.10%
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 cypress cone oil egypt @ 0.2%
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 erigeron graveolens l. oil iran @ 5.20%
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 eucalyptus globulus fruit oil @ 0.28%
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 geranium oil rwanda @ 0.35%
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 hinoki root oil @ 5.88%
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 hinoki wood oil @ 10.61%
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 hyssop leaf
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 hyssop oil CO2 extract @ 0.4%
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 hyssop shoot
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 labdanum oil @ 0.81%
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 laurel leaf oil turkey @ trace%
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 lavandin oil abrialis @ 0.21%
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 lavandin oil grosso @ 0.20%
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 lavender oil france @ 0.99%
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 lavender oil spike france @ 0.06%
Data  GC  Search Trop  Picture
 lavender oil spike spain @ 0.08%
Data  GC  Search Trop  Picture
 lemon balm shoot
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 lemon verbena oil morocco @ 0.9%
Data  GC  Search Trop  Picture
 lemon verbena oil turkey @ 0.97%
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 marjoram pot oil turkey @ 0.00-0.12%
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 microstrobos niphophilus leaf oil australia @ 0.70%
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 mikania cordata (burm. f.) b.l. robinson var. cordata leaf oil france @ 0.10%
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 pepper tree berry oil @ 1.39%
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 pepper tree leaf oil @ 4.70%
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 peppermint oil CO2 extract @ 0.60%
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 phoebe oil brazil @ 0.78%
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 pimenta leaf oil @ 6.64%
Data  GC  Search Trop  Picture
 pine needle oil dwarf @ 2.17%
Data  GC  Search Trop  Picture
 pinus formosana hayata
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 pinus pentaphylla
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 polyalthia australis (benth.) jessup leaf oil australia @ 0.90%
Data  GC  Search Trop  Picture
 pteronia oil @ 0.40%
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 rosemary oil france @ 0.00-0.12%
Data  GC  Search Trop  Picture
 rosemary oil morocco @ 0.00-0.11%
Data  GC  Search Trop  Picture
 salvia officinalis seed oil tunisia @ 0.15%
Data  GC  Search Trop  Picture
 salvia plebeia oil @ 10.21%
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 salvia sclarea seed oil tunisia @ 0.52%
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 satureja viminea l. oil costa rica @ trace%
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 sideritis montana l. oil bulgaria @ 1.80%
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 thyme oil wild or creeping canada @ 1.00%
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 thyme oil wild or creeping france @ 3.40%
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 thymus richardii pers. subsp. nitidus (guss.) jalas oil italy @ 4.00%
Data  GC  Search Trop  Picture
 torreya nucifera
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 yarrow oil @ 0.40%
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 yarrow oil greece @ 0.10%
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 zanthoxylum bracchyacanthum l. leaf oil australia @ 0.30%
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Synonyms:
 amorphan-3-en-9beta-ol
(-)-amorphan-3-en-9beta-ol
10bH-cadin-4-en-10-ol
 cadin-4-en-10beta-ol
.tau.-cadinol
10-epicadinol
10-epi-a-cadinol
epi-alpha-cadinol
 cedrelanol
(1S,4S,4aR,8aR)-1,6-dimethyl-4-(propan-2-yl)-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-ol
(1S,4S,4aR,8aR)-1,6-dimethyl-4-propan-2-yl-3,4,4a,7,8,8a-hexahydro-2H-naphthalen-1-ol
sesquigoyol
1-naphthalenol, 1,2,3,4,4a,7,8,8a-octahydro-1,6-dimethyl-4-(1-methylethyl)-, (1S,4S,4aR,8aR)-
(1S-(1alpha,4alpha, 4aalpha,8abeta))- 1,2,3,4,4a,7,8,8a-octahydro-1,6-dimethyl-4-(1-methyl ethyl)-1-naphthalenol
 pilgerol
(1S,4S,4aR,8aR)-4-isopropyl-1,6-dimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-ol
 torreyol
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Articles:
PubMed: Comparison of the volatile oil composition of three Atalantia species.
PubMed: Chemical composition, antibacterial and cytotoxic activities of the essential oil from the flowers of Tunisian Convolvulus althaeoides L.
PubMed: Essential oils of Chiliadenus lopadusanus (Asteraceae).
PubMed: Headspace solid-phase microextraction-gas chromatography-mass spectrometry characterization of propolis volatile compounds.
PubMed: [Sesquiterpenes from stem of Schisandra glaucescens].
PubMed: Phytochemicals from Cunninghamia konishii Hayata act as antifungal agents.
PubMed: Changes in volatile compound composition of Antrodia camphorata during solid state fermentation.
PubMed: Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute hepatitis in mice.
PubMed: Phytochemical analysis and in vitro antimicrobial and free-radical-scavenging activities of the essential oils from Euryops arabicus and Laggera decurrens.
PubMed: A novel brominated cuparene-derived sesquiterpene ether from the red alga Laurencia sp.
PubMed: Essential oil composition and in vivo volatiles emission by different parts of Coleostephus myconis capitula.
PubMed: Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves.
PubMed: Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.).
PubMed: Chemical analysis and biological activity of the essential oils of two endemic Soqotri Commiphora species.
PubMed: Sesquiterpenoids from Teucrium ramosissimum.
PubMed: Essential oil variability in natural populations of Picea omorika, a rare European conifer.
PubMed: Antibacterial terpenes from the oleo-resin of Commiphora molmol (Engl.).
PubMed: Dendritic Cells Promoted by Ginseng Saponins Drive a Potent Th1 Polarization.
PubMed: Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs.
PubMed: Chemical composition and antimicrobial activity of the essential oil of Teucrium ramosissimum (Lamiaceae).
PubMed: Sesquiterpenes from the wood of Juniperus lucayana.
PubMed: Chemical composition and in vitro antifungal and antioxidant activity of the essential oil and methanolic extract of Teucrium sauvagei Le Houerou.
PubMed: Molecular and enzymatic characterizations of novel bifunctional 3beta-hydroxysteroid dehydrogenases/C-4 decarboxylases from Arabidopsis thaliana.
PubMed: T-cadinol and calamenene induce dendritic cells from human monocytes and drive Th1 polarization.
PubMed: Three abietane diterpenes and two diterpenes incorporated sesquiterpenes from the bark of Cryptomeria japonica.
PubMed: Larvicidal, antimycobacterial and antifungal compounds from the bark of the Peruvian plant Swartzia polyphylla DC.
PubMed: Analysis of the essential oil composition of eight Anthemis species from Greece.
PubMed: New constituents of Leontopodium alpinum and their in vitro leukotriene biosynthesis inhibitory activity.
PubMed: Phytochemical investigation and evaluation of anti-inflammatory and anti-arthritic activities of essential oil of Strobilanthus ixiocephala Benth.
PubMed: Antifouling substances against larvae of the barnacle Balanus amphitrite from the marine sponge, Acanthella cavernosa.
PubMed: A linear sesterterpene, two squalene derivatives and two peptide derivatives from Croton hieronymi.
PubMed: GC-MS analysis of essential oil of Shorea robusta bast.
PubMed: Cadinane-type sesquiterpenes from the roots of Taiwania cryptomerioides Hayata.
PubMed: Influence of the parasite Viscum cruciatum Sieber on the chemical constituents of Crataegus monogyna Jacq.
PubMed: Two octanordammarane triterpenes from Commiphora kua.
PubMed: Five new cadinane-type sesquiterpenes from the heartwood of Chamaecyparis obtusa var. formosana.
PubMed: Antimite activity of essential oils and their constituents from Taiwania cryptomerioides.
PubMed: 17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).
PubMed: Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti).
PubMed: (+)-10 alpha-Hydroxy-4-muurolen-3-one, a new inhibitor of leukotriene biosynthesis from a Favolaschia species. Comparison with other sesquiterpenes.
PubMed: Calcium antagonistic properties of the sesquiterpene T-cadinol and related substances: structure-activity studies.
PubMed: Calcium channels at the adrenergic neuroeffector junction in the rabbit ear artery.
PubMed: Calcium antagonistic properties of the sesquiterpene T-cadinol: a comparison with nimodipine in the isolated rat aorta.
PubMed: T-cadinol: a pharmacologically active constituent of scented myrrh: introductory pharmacological characterization and high field 1H- and 13C-NMR data.
PubMed: Sterol conjugates of two phenotypically different calli of Beta vulgaris.
PubMed: The essential oil from Thymus praecox ssp. arcticus growing in Iceland.
PubMed: Adenosine deaminase inhibitors. Synthesis and biological evaluation of (+/-)-3,6,7,8-tetrahydro-3-[(2-hydroxyethoxy)methyl]imidazo[4,5-d] [1,3]diazepin-8-ol and some selected C-5 homologues of pentostatin.
PubMed: Sterol biosynthesis in the echinoderm Asterias rubens.
PubMed: The sterols of the echinoderm Asterias rubens.
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