Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless clear liquid (est) |
Assay: | 99.00 to 100.00 % sum of isomers
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.14200 to 1.15200 @ 25.00 °C.
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Pounds per Gallon - (est).: | 9.503 to 9.586
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Refractive Index: | 1.57500 to 1.58500 @ 20.00 °C.
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Boiling Point: | 86.00 °C. @ 10.00 mm Hg
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Boiling Point: | 210.00 to 211.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.161000 mmHg @ 25.00 °C. (est) |
Vapor Density: | 4.8 ( Air = 1 ) |
Flash Point: | 193.00 °F. TCC ( 89.44 °C. )
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logP (o/w): | 0.153 (est) |
Soluble in: |
| alcohol | | dipropylene glycol | | water, 3390 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor Type: nutty |
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| nutty earthy peanut musty coffee vegetable |
Odor Description: at 0.10 % in dipropylene glycol. | nutty earthy peanut musty coffee vegetable |
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| toasted popcorn roasted almond hazelnut peanut cashew nutty caramellic corn chip |
Odor Description: at 1.00 %. | Toasted popcorn, roasted almond, hazelnut, peanut and cashew nutty, with a caramellic and corn-chip nuance Mosciano, Gerard P&F 25, No. 3, 25, (2000) |
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Flavor Type: nutty |
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| peanut pecan nutty popcorn corn chip burnt musty |
Taste Description: at 3.00 - 10.00 ppm. | Peanut and pecan nutty, popcorn and corn-chip-like with a burnt musty nuance Mosciano, Gerard P&F 25, No. 3, 25, (2000) |
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Odor and/or flavor descriptions from others (if found). |
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R C Treatt & Co Ltd |
2-Methylthio-3(5/6)-methylpyrazine Kosher |
Odor Description: | Nutty, roast almonds, hazelnut, toasted cracker notes |
Taste Description: | nutty Used in roast nut, chocolate and bread flavorus. The COE# 2290 is for 2-methyl-3-thiomethylpyrazine (not the isomeric mixture). Normal use levels in finished consumer product: 0.02-2 ppm. Council of Europe limits: Foods (4 ppm). |
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Kingchem Laboratories |
2 METHYLTHIO-3(or 5)-METHYLPYRAZINE |
Odor Description: | Nut, processed meat, vegetable |
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Alfrebro |
2-METHYLTHIO-3(5)-METHYL PYRAZINE |
Odor Description: | Nutty, Vegetable, Crackers |
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FCI SAS |
2-METHYLTHIO-(3 or 5)-METHYL PYRAZINE |
Odor Description: | roast, coffee, meat odor, pungent |
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Cosmetic Information:
Suppliers:
Advanced Biotech |
2 METHYLTHIO 3(5/6) METHYL PYRAZINE
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Alfrebro |
2-METHYLTHIO-3(5)-METHYL PYRAZINE
Odor: Nutty, Vegetable, Crackers |
Ambles Nature et Chimie |
2-METHYLTHIO-(3or5or6)-METHYL PYRAZINE
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Anhui Haibei |
2-Methylthio-3 (5/6)-methyl pyrazine
Odor: Nutty, processed meat, vegetable |
Anhui Suzhou Jinli Aromatic Chemicals |
2-Methyllhio-(3or5)-methyl pyrazine
Odor: nut, cooked meat, vegetable |
Beijing Lys Chemicals |
2-Methylthio-3(5/6)-methylpyrazine
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Berjé |
2-Methyl Thio-3 (5,6) Methyl Pyrazine
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Media |
Charkit Chemical |
METHYLTHIO-3(5/6)METHYL PYRAZINE, 2- FEMA 3208
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De Monchy Aromatics |
2-methylthio-3(5,6)-methyl pyrazine
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Endeavour Specialty Chemicals |
2-Methylthio-3(5/6)-methylpyrazine
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Speciality Chemical Product Groups |
Ernesto Ventós |
2-METHYLTHIO-3(5/6)-METHYLPYRAZINE
Odor: NUT, CARNE, VEGETAL |
FCI SAS |
2-METHYLTHIO-(3 or 5)-METHYL PYRAZINE
Odor: roast, coffee, meat odor, pungent |
Frutarom |
2-METHYLTHIO-(3 OR 6)-METHYLPYRAZINE
KOSHER Flavor: Earthy, Green, Musty, Nutty, Vegetable |
CBD Offering |
IFF |
2-METHYLTHIO-(3 OR 6)-METHYLPYRAZINE
KOSHER Flavor: Earthy, Green, Musty, Nutty, Vegetable |
Indukern F&F |
2-METHYLTHIO-3(5/6)-METHYL PYRAZINE
Odor: EARTHY, PEANUT, COFFEE, VEGETABLE |
Jiangyin Healthway |
2-Methylthio-3(5/6)-methyl pyrazine
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New functional food ingredients |
Jinan Enlighten Chemical Technology(Wutong Aroma ) |
2-Methyl-3(5or6)-(methylthio) pyrazine, Kosherk
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Kingchem Laboratories |
2 METHYLTHIO-3(or 5)-METHYLPYRAZINE
Odor: Nut, processed meat, vegetable |
Lluch Essence |
PYRAZINE 2-METHYLTHIO-3(6)-METHYL
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M&U International |
2-METHYLTHIO-3(5/6)-METHYL PYRAZINE, Kosher
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Pearlchem Corporation |
2-Methlthio-3(5/6)-methyl Pyrazine
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Penta International |
2-METHYLTHIO-3,5-METHYLPYRAZINE
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Phoenix Aromas & Essential Oils |
Pyrazine, 2-Methyl-3(6)-5-Methyl Thio
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R C Treatt & Co Ltd |
2-Methylthio-3(5/6)-methylpyrazine
Kosher Odor: Nutty, roast almonds, hazelnut, toasted cracker notes Flavor: nutty Used in roast nut, chocolate and bread flavorus. The COE# 2290 is for 2-methyl-3-thiomethylpyrazine (not the isomeric mixture). Normal use levels in finished consumer product: 0.02-2 ppm. Council of Europe limits: Foods (4 ppm). |
Riverside Aromatics |
2-METHYL-3[5/6]-METHYLTHIOPYRAZINE
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Robinson Brothers |
2-Methylthio-3(5/6)-methylpyrazine
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https://www.robinsonbrothers.uk/chemistry-competences |
Sigma-Aldrich |
(Methylthio)methylpyrazine, mixture of isomers, ≥98%, FG
Odor: almond; caramel; musty; coffee; vegetable |
Certified Food Grade Products |
Sunaux International |
2-Methylthio-3(5/6)-methyl Pyrazine
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Taytonn ASCC |
2-Methylthio-3(5/6)-methylpyrazine
Odor: Earthy, Green, Musty, Nutty, Vegetable |
Tengzhou Jitian Aroma Chemiclal |
2-Methyl thio-3(5/6)-methyl pyrazine
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Tengzhou Xiang Yuan Aroma Chemicals |
2-Methylthio-3-(5/6)-Methyl Pyrazine
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Tianjin Danjun International |
2-Methylthio-3(5/6)-methylpyrazine
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WholeChem |
2-Methylthio-3(5/6)-methylpyrazine
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 22 - Harmful if swallowed. R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
gavage-rat LD50 1970 mg/kg (Posternak et al., 1975)
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for 2-methyl thio-3,5 or 6-methyl pyrazine usage levels up to: | | 0.1000 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 6.30 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 13.00 (μg/capita/day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 4 |
Click here to view publication 4 |
| average usual ppm | average maximum ppm |
baked goods: | - | 4.00000 |
beverages(nonalcoholic): | - | - |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 2.00000 |
fruit ices: | - | 2.00000 |
gelatins / puddings: | - | 2.00000 |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | 2.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s): |
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf |
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010) View page or View pdf |
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 67952-65-2 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 100930 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 3 |
| 2-methyl-3-methylsulfanylpyrazine |
Chemidplus: | 0067952652 |
RTECS: | UQ3900000 for cas# 67952-65-2 |
References:
Other Information:
Potential Blenders and core components note
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For Odor |
No odor group found for these |
1- | propanoyl pyrrole | |
| sulfuryl octanoate | FL/FR |
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| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
| sulfuryl propionate | FL/FR |
alcoholic |
| propyl alcohol | FL/FR |
balsamic |
2- | acetyl furan | FL/FR |
buttery |
| acetyl butyryl | FL/FR |
| acetyl propionyl | FL/FR |
3,4- | hexane dione | FL/FR |
camphoreous |
| butyrophenone | FL/FR |
chocolate |
| chocolate pyrazine A | FL/FR |
| cocoa hexenal | FL/FR |
2,5- | dimethyl pyrazine | FL/FR |
2- | methoxy-3-methyl pyrazine | FL/FR |
2,4,5- | trimethyl thiazole | FL/FR |
cocoa |
2-iso | butyl-3,5-(and 3,6)-dimethyl pyrazine | FL/FR |
coconut |
| coconut naphthalenone | FL/FR |
gamma- | octalactone | FL/FR |
coffee |
1- | hydroxy-2-butanone | FL/FR |
| popcorn pyrimidine | FL/FR |
earthy |
| nutty pyrazine | FL/FR |
fruity |
| nonyl isovalerate | FL/FR |
2- | heptyl furan | FL/FR |
| hazelnut pyrazine | FL/FR |
nutty |
3- | acetyl pyridine | FL/FR |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
3,6- | cocoa pyrazine | FL/FR |
3,5- | cocoa pyrazine | FL/FR |
2,3- | dimethyl pyrazine | FL/FR |
2- | ethyl pyrazine | FL/FR |
| filbert heptenone | FL/FR |
| filbert pyrazine | FL/FR |
(E)- | filbertone | FL/FR |
| methoxymethyl pyrazine | FL/FR |
2- | methyl pyrazine | FL/FR |
5- | methyl quinoxaline | FL/FR |
2- | methyl-3-ethoxypyrazine | FL/FR |
2- | methyl-3-pentenoic acid | FL/FR |
| nutty quinoxaline | FL/FR |
| peanut fragrance | FR |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
2,3,5- | trimethyl pyrazine | FL/FR |
phenolic |
2-iso | propyl phenol | FL/FR |
popcorn |
2- | acetyl pyrazine | FL/FR |
2- | acetyl pyridine | FL/FR |
2- | acetyl thiazole | FL/FR |
roasted |
2- | acetyl-2-pyrroline | |
| furfuryl thioacetate | FL/FR |
tonka |
| whiskey lactone | FL/FR |
waxy |
| butyl laurate | FL/FR |
woody |
| cedrenyl acetate | FR |
2- | methoxy-4-vinyl phenol | FL/FR |
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For Flavor |
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No flavor group found for these |
2- | acetyl-2-pyrroline | |
2- | acetyl-5-methyl pyrazine | FL |
2- | acetyl-6-methyl pyrazine | FL |
(E)- | aconitic acid | FL |
2-iso | butyl-3,5-(and 3,6)-dimethyl pyrazine | FL/FR |
2(4)-iso | butyl-4(2),6-dimethyl dihydro-4H-1,3,5-dithiazine | FL |
| butyrophenone | FL/FR |
| chocolate pyrazine A | FL/FR |
| chocolate pyrazine B | FL |
| coconut naphthalenone | FL/FR |
6,7- | dihydro-2,3-dimethyl-5H-cyclopentapyrazine | FL |
| dimethyl dihydrocyclopentapyrazine | FL |
2,5- | dimethyl thiazole | FL |
4,5- | dimethyl-2-ethyl thiazole | FL |
| ethyl dimethyl pyrazine | FL |
(E)- | filbertone | FL/FR |
| methyl 2-(methyl thio) acetate | FL |
2- | methyl-3-ethoxypyrazine | FL/FR |
2- | methyl-3-pentenoic acid | FL/FR |
| nonyl isovalerate | FL/FR |
| peanut dithiazine | FL |
2- | propionyl pyrrole | FL |
2-iso | propyl-4-methyl-3-thiazoline | FL |
| pyrazines mixture | FL |
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
|
| sulfuryl formate | FL |
| sulfuryl octanoate | FL/FR |
| sulfuryl propionate | FL/FR |
alcoholic |
| propyl alcohol | FL/FR |
alliaceous |
| shallot oil | FL |
astringent |
1- | propanoyl pyrrole | |
bready |
2- | propionyl thiazole | FL |
brown |
1- | hydroxy-2-butanone | FL/FR |
burnt |
2- | methyl quinoxaline | FL |
buttery |
| butter pecan flavor | FL |
3,4- | hexane dione | FL/FR |
cocoa |
| cocoa hexenal | FL/FR |
corn chip |
2- | acetyl pyridine | FL/FR |
2- | acetyl thiazole | FL/FR |
2- | acetyl-2-thiazoline | FL |
| popcorn pyrimidine | FL/FR |
creamy |
| acetyl butyryl | FL/FR |
fatty |
2- | heptyl furan | FL/FR |
fishy |
4,5- | dimethyl thiazole | FL |
green |
| dihydroxyacetophenone (mixed isomers) | FL |
lactonic |
gamma- | octalactone | FL/FR |
metallic |
2,5- | dihydroxy-1,4-dithiane | FL |
musty |
2,5- | dimethyl pyrazine | FL/FR |
2- | ethoxythiazole | FL |
| hazelnut pyrazine | FL/FR |
2,3,5- | trimethyl pyrazine | FL/FR |
nutty |
2- | acetyl furan | FL/FR |
3- | acetyl pyridine | FL/FR |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| aconitic acid | FL |
| arachis hypogaea fruit extract | FL |
3,6- | cocoa pyrazine | FL/FR |
3,5- | cocoa pyrazine | FL/FR |
3,5(6)- | cocoa pyrazine | FL |
2,5- | diethyl-3-methyl pyrazine | FL |
2,3- | dimethyl pyrazine | FL/FR |
2- | ethyl pyrazine | FL/FR |
| filbert heptenone | FL/FR |
| filbert pyrazine | FL/FR |
european | hazelnut oleoresin | FL |
2- | methoxy-3-methyl pyrazine | FL/FR |
| methoxymethyl pyrazine | FL/FR |
2- | methyl pyrazine | FL/FR |
5- | methyl quinoxaline | FL/FR |
| nutty pyrazine | FL/FR |
| nutty quinoxaline | FL/FR |
| peanut brittle flavor | FL |
| peanut flavor | FL |
roasted | peanut flavor | FL |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
2,4,5- | trimethyl thiazole | FL/FR |
popcorn |
2- | propionyl-2-thiazoline | FL |
roasted |
2- | acetyl pyrazine | FL/FR |
| furfuryl thioacetate | FL/FR |
smoky |
2- | methoxy-4-vinyl phenol | FL/FR |
solvent |
2-iso | propyl phenol | FL/FR |
toasted |
| acetyl propionyl | FL/FR |
waxy |
| butyl laurate | FL/FR |
woody |
| whiskey lactone | FL/FR |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| methyl 2-thio 3-methyl pyrazine | | methyl 3,5 or 6-methyl thiopyrazine | | methyl 3,5 or 6-methylthiopyrazine | 2- | methyl thio-3 (5,6) methyl pyrazine | 3(5 or 6)-( | methyl thio)-2-methyl pyrazine | ( | methyl thio)-3,5 or 6-methyl pyrazine | 2-( | methyl thio)-3(5 or 6)methyl pyrazine | 2- | methyl-3-methylsulfanylpyrazine | 2- | methyl-3,(5 or 6)-methyl thiopyrazine | 2- | methyl-3,(5 or 6)-methylthiopyrazine | | methyl-3,5 or 6-(methyl thio) pyrazine | | methyl-3,5 or 6-(methylthio)pyrazine | 2- | methyl-3,5 or 6-methylthiopyrazine | 2- | methyllhio-(3or5)-methyl pyrazine | 2-[( | methylsulfanyl)methyl]pyrazine | (3, 5 or 6)- | methylthio-2-methylpyrazine | 2- | methylthio-3 (5/6) -methyl pyrazine | 2- | methylthio-3(5/6) methyl pyrazine | 2- | methylthio-3(5/6)-methyl pyrazine | 2- | methylthio-3(5/6)-methylpyrazine | 2- | methylthio-3(6)methyl pyrazine | 2 | methylthio-3(or 5)-methylpyrazine | 3(5 or 6)-( | methylthio)-2-methylpyrazine | ( | methylthio)-3,5 or 6-methylpyrazine | 2-( | methylthio)-3(5 or 6)methylpyrazine | (( | methylthio)methyl)pyrazine | 2-(( | methylthio)methyl)pyrazine | ( | methylthio)methylpyrazine | | popcorn thiopyrazine | | pyrazine, ((methylthio)methyl)- | | pyrazine, [(methylthio)methyl]- | | pyrazine, 2-(methylthiomethyl)- | | pyrazine, 2-[(methylthio)methyl]- | | pyrazine, 2-methyl-3(6)-5-methyl thio | | pyrazinylmethyl methyl sulfide |
Articles:
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