Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Assay: | 99.00 to 100.00 % sum of isomers
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 1.13800 to 1.14800 @ 20.00 °C.
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Pounds per Gallon - (est).: | 9.480 to 9.564
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Refractive Index: | 1.58000 to 1.58600 @ 20.00 °C.
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Boiling Point: | 153.00 to 156.00 °C. @ 10.00 mm Hg
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Flash Point: | 134.00 °F. TCC ( 56.67 °C. )
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logP (o/w): | 1.970 |
Soluble in: |
| alcohol | | water, 198.1 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor Type: coffee |
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| sulfurous nutty coffee roasted coffee cooked meaty |
Odor Description: at 0.10 % in dipropylene glycol. | sulfurous nutty roasted coffee cooked meat |
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Odor and/or flavor descriptions from others (if found). |
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Kingchem Laboratories |
2 FURFURYLTHIO-(3 or 5)-METHYLPYRAZINE (2-Methyl-3-(furfurylthio)pyrazine) |
Odor Description: | Coffee and sesame seed oil |
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Cosmetic Information:
Suppliers:
Advanced Biotech |
2 FURFURYLTHIO 3(5/6)METHYL PYRAZINE
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Anhui Suzhou Jinli Aromatic Chemicals |
2-Furfurylthio-(3 or 5)-methyl pyrazine
Odor: coffee, Fried Sesame |
Beijing Lys Chemicals |
2-Methyl-3(5/6)(furfurylthio)pyrazine
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BOC Sciences |
For experimental / research use only. |
2-Furfurylthio-3-methylpyrazine 95%
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Charkit Chemical |
METHYL-3(5/6)FURFURYLTHIO) PYRAZINE, 2- FEMA 3189
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FCI SAS |
2-FURFURYLTHIO-(3 or 5)-METHYL PYRAZINE
Odor: Roasted coffee, gingili |
Fleurchem |
2-methyl (3-furfuryl-thio) pyrazine
|
Jiangyin Healthway |
2-Furfurylthio-3(5/6)-methyl pyrazine
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New functional food ingredients |
Jinan Enlighten Chemical Technology(Wutong Aroma ) |
2-methyl-3(5or6)-Furfurylthio pyrazine, Kosherk
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Kingchem Laboratories |
2 FURFURYLTHIO-(3 or 5)-METHYLPYRAZINE (2-Methyl-3-(furfurylthio)pyrazine)
Odor: Coffee and sesame seed oil |
M&U International |
2-FURFURYLTHIO-3(5/6)-METHYL PYRAZINE, Kosher
|
Penta International |
2-METHYL-3,5,6-(FURFURYLTHIO)PYRAZINE
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Reincke & Fichtner |
2-Methyl-3-,5 Or 6-(furfurylthio)pyrazine (mixture Of Isomers)
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Sigma-Aldrich |
2-Methyl-3(5 or 6)-furfurylthiopyrazine, 97%
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Certified Food Grade Products |
Sunaux International |
2-Furfurylthio-3(5/6)-methyl Pyrazine
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Synerzine |
2-Methyl-3,5 or 6-(Furfurylthio)-Pyrazine
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Taytonn ASCC |
2-Methyl-3(5/6)(Furfurylthio)
Odor: Coffee, Nutty, Roast |
Tengzhou Jitian Aroma Chemiclal |
2-Furfurylthio-3(5/6)-methyl pyrazine
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Tengzhou Xiang Yuan Aroma Chemicals |
2-Furfuralthio-3-(5/6)-Methyl Pyrazine
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Tianjin Danjun International |
2-Methyl-3(5/6)(furfurylthio)pyrazine
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WholeChem |
2-Methyl-3(5/6)(furfurylthio)pyrazin
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 10 - Flammable. R 22 - Harmful if swallowed. R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for 2-methyl-3-,5 or 6-(furfuryl thio) pyrazine usage levels up to: | | 0.0300 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.37 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.70 (μg/capita/day) |
NOEL (No Observed Effect Level): | 1.70 (mg/kg bw per day) |
Structure Class: | III |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 4 |
Click here to view publication 4 |
| average usual ppm | average maximum ppm |
baked goods: | - | 1.00000 |
beverages(nonalcoholic): | - | 1.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | 1.00000 |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 1.00000 |
fruit ices: | - | 1.00000 |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | 1.00000 |
hard candy: | - | - |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Scientific Opinion on Flavouring Group Evaluation 13Rev1: Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of “Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14” evaluated by EFSA in FGE.13Rev1 (2009) View page or View pdf |
Flavouring Group Evaluation 67 (FGE.67): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13Rev2): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 67, Revision 1 (FGE.67Rev.1): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 65, Revision 1 (FGE.65Rev1): Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of ‘Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14’ evaluated by EFSA in FGE.13Rev2 (2011) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 13 Revision 3 (FGE.13Rev3): furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 101003 |
National Institute of Allergy and Infectious Diseases: | Data |
WISER: | UN 1993 |
WGK Germany: | 3 |
| 2-[(furan-2-ylmethyl)sulfanyl]-5-methylpyrazine |
Chemidplus: | 0059035982 |
References:
Other Information:
Potential Blenders and core components note
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For Odor |
No odor group found for these |
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| semduramicin sodium | |
| dimethyl trisulfide | FL/FR |
| methyl furfuryl disulfide | FL/FR |
balsamic |
2- | acetyl furan | FL/FR |
2- | ethyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
(R)-2- | methyl butyraldehyde | |
| caramel furanone solution | FL/FR |
| coffee dione | FL/FR |
| cyclotene | FL/FR |
| fenugreek oleoresin | FL/FR |
| malt fragrance | FR |
5- | methyl furfural | FL/FR |
chocolate |
| cocoa oleoresin | FL/FR |
2,6- | dimethyl pyrazine | FL/FR |
2,4,5- | trimethyl thiazole | FL/FR |
cocoa |
2- | methyl butyraldehyde | FL/FR |
coffee |
| cappuccino fragrance | FR |
| cichorium intybus root extract | FL/FR |
| cichorium intybus root solid extract | FL/FR |
| coffea arabica fruit extract | FL/FR |
roasted | coffea arabica seed extract | FL/FR |
| coffea arabica seed extract | FL/FR |
| coffea arabica seed oil | FL/FR |
| coffee absolute | FL/FR |
arabica | coffee bean butter | FL/FR |
roasted arabica | coffee bean essence | FL/FR |
roasted | coffee bean extract | FL/FR |
roasted arabica | coffee bean oil | FL/FR |
roasted arabica | coffee bean oil CO2 extract | FL/FR |
| coffee bean oil extract | FL/FR |
| coffee difuran | FL/FR |
| coffee fragrance | FR |
| coffee resinoid | FL/FR |
| furfuryl mercaptan | FL/FR |
1- | hydroxy-2-butanone | FL/FR |
| nutty pyrazine | FL/FR |
(S)-2- | methyl butyraldehyde | |
| tropical thiazole | FL/FR |
herbal |
| wormwood oil america | FL/FR |
| wormwood oil italy | FL/FR |
| wormwood oil poland | FL/FR |
| wormwood oil replacer | FR |
medicinal |
2,6- | xylenol | FL/FR |
moldy |
| strawberry furanone methyl ether | FL/FR |
| menthofuran | FL/FR |
3,5- | cocoa pyrazine | FL/FR |
3,6- | cocoa pyrazine | FL/FR |
2,3- | dimethyl pyrazine | FL/FR |
4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
2- | ethyl pyrazine | FL/FR |
2- | ethyl-4-methyl thiazole | FL/FR |
| filbert heptenone | FL/FR |
| filbert heptenone B | FL/FR |
| hazelnut fragrance | FR |
5- | methyl quinoxaline | FL/FR |
2- | methyl-3-(methyl thio) pyrazine | FL/FR |
| sesame absolute | FL/FR |
| sesame absolute CO2 extract | FL/FR |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
phenolic |
para-alpha- | dimethyl styrene | FL/FR |
popcorn |
2- | acetyl pyrazine | FL/FR |
| fenugreek resinoid | FL/FR |
| trigonella foenum-graecum seed oil CO2 extract | FL/FR |
savory |
laevo- | methionyl glycine | |
sulfurous |
| benzothiazole | FL/FR |
| dodecyl mercaptan | |
| furfuryl thioacetate | FL/FR |
S- | furfuryl thioformate | FL/FR |
2- | mercaptopropionic acid | FL/FR |
2- | methyl 5-(methyl thio) furan | FL/FR |
3- | thiohexanol | FL/FR |
sweet |
2- | hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one | FL/FR |
vegetable |
1- | furfuryl pyrrole | FL/FR |
woody |
| juniper berry oleoresin | FL/FR |
2- | methyl-3-isopropyl pyrazine | |
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For Flavor |
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No flavor group found for these |
2- | acetyl-6-methyl pyrazine | FL |
1,2- | butane dithiol | FL |
| coffea arabica fruit extract | FL/FR |
| dimethyl dihydrocyclopentapyrazine | FL |
(Z+E)-2,5- | dimethyl-3-tetrahydrofuran thiol | FL |
(Z+E)-2,5- | dimethyl-3-thioacetoxytetrahydrofuran | FL |
2,5- | dimethyl-3-thiofuroyl furan | FL |
3-( | ethyl thio) butanol | FL |
2- | ethyl-3-methyl thiopyrazine | FL |
2- | ethyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
(Z+E)-5- | ethyl-4-methyl-2-(2-butyl) thiazoline | FL |
(Z+E)-5- | ethyl-4-methyl-2-(2-methyl propyl) thiazoline | FL |
2- | ethyl-5(or6)-methyl pyrazine | FL |
2- | formyl pyrrole | FL |
2- | hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one | FL/FR |
3- | mercapto-3-methyl butyl formate | FL |
4- | mercapto-3-methyl-2-butanol | FL |
laevo- | methionyl glycine | |
(S)-2- | methyl butyraldehyde | |
(R)-2- | methyl butyraldehyde | |
| methyl dihydrofuran thiol | FL |
2- | methyl thiazolidine | FL |
2- | methyl-3-(methyl thio) pyrazine | FL/FR |
3-((2- | methyl-3-furyl)thio)-4-heptanone | FL |
1,9- | nonane dithiol | FL |
| pyrazines mixture | FL |
| semduramicin sodium | |
3- | thienyl mercaptan | FL |
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5- | acetyl-2,3-dihydro-1,4-thiazine | FL |
3,7- | dimethyl-2,6-octadien-1-yl cyclopropyl carboxamide | FL |
2- | methyl-1-methyl thio-2-butene | FL |
| pyrrolidino-(1,2E)-4H-2,4-dimethyl-1,3,5-dithiazine | FL |
alliaceous |
| benzyl mercaptan | FL |
| dicyclohexyl disulfide | FL |
| dimethyl trisulfide | FL/FR |
| tropical thiazole | FL/FR |
brown |
| fenugreek oleoresin | FL/FR |
1- | hydroxy-2-butanone | FL/FR |
5- | methyl furfural | FL/FR |
burnt |
| furfuryl alcohol | FL |
2- | methyl quinoxaline | FL |
2,6- | xylenol | FL/FR |
caramellic |
| caramel furanone | FL |
| caramel furanone solution | FL/FR |
| cyclotene | FL/FR |
| fenugreek resinoid | FL/FR |
chocolate |
| cocoa oleoresin | FL/FR |
coffee |
| cichorium intybus root extract | FL/FR |
| cichorium intybus root solid extract | FL/FR |
roasted | coffea arabica seed extract | FL/FR |
| coffea arabica seed extract | FL/FR |
| coffea arabica seed oil | FL/FR |
| coffee absolute | FL/FR |
arabica | coffee bean butter | FL/FR |
roasted arabica | coffee bean essence | FL/FR |
roasted | coffee bean extract | FL/FR |
roasted arabica | coffee bean oil CO2 extract | FL/FR |
| coffee bean oil extract | FL/FR |
| coffee difuran | FL/FR |
| coffee dione | FL/FR |
| coffee distillates | FL |
| coffee pyrazine | FL |
| coffee resinoid | FL/FR |
| difurfuryl ether | FL |
| diisoamyl thiomalate | FL |
2,4- | dimethyl thiazole | FL |
2- | ethyl-4-methyl thiazole | FL/FR |
| furfuryl mercaptan | FL/FR |
| methyl furfuryl disulfide | FL/FR |
| methyl furfuryl thiol | FL |
2- | thiophene thiol | FL |
earthy |
| difurfuryl sulfide | FL |
2- | methyl-3-isopropyl pyrazine | |
fruity |
| furfuryl isobutyrate | FL |
| furfuryl isovalerate | FL |
| furfuryl propionate | FL |
fusel |
2- | methyl butyraldehyde | FL/FR |
green |
2- | methyl-5-isopropyl pyrazine | FL |
herbal |
| wormwood oil america | FL/FR |
| wormwood oil italy | FL/FR |
| wormwood oil poland | FL/FR |
meaty |
| benzothiazole | FL/FR |
2,6- | dimethyl pyrazine | FL/FR |
2,6- | dimethyl thiophenol | FL |
| dodecyl mercaptan | |
1,1- | ethane dithiol 1% in ethanol 94.5% / ethyl acetate 4% | FL |
3- | mercapto-2-butanone | FL |
(R,S)-2- | mercapto-3-butanol | FL |
2- | mercaptopropionic acid | FL/FR |
2- | methyl 3-(methyl thio) furan | FL |
12- | methyl tridecanal | FL |
bis(2- | methyl-3-furyl) disulfide | FL |
S-(2- | methyl-3-furyl) ethane thioate | FL |
| propyl 2-mercaptopropionate | FL |
| pyrazinyl ethane thiol | FL |
2- | pyridinyl methane thiol | FL |
| thialdine | FL |
molasses |
| molasses blackstrap | FL |
moldy |
| strawberry furanone methyl ether | FL/FR |
mustard |
| furfuryl methyl ether | FL |
musty |
2- | ethoxythiazole | FL |
| menthofuran | FL/FR |
2- | methyl 5-(methyl thio) furan | FL/FR |
nutty |
2- | acetyl furan | FL/FR |
2- | acetyl-4-methyl thiazole | FL |
2- | butyl-2-butenal | FL |
3,6- | cocoa pyrazine | FL/FR |
3,5- | cocoa pyrazine | FL/FR |
2,3- | dimethyl pyrazine | FL/FR |
4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
2- | ethyl pyrazine | FL/FR |
1- | ethyl-2-acetyl pyrrole | FL |
| filbert heptenone | FL/FR |
| filbert heptenone B | FL/FR |
5- | methyl quinoxaline | FL/FR |
| nutty pyrazine | FL/FR |
| nutty thiazole | FL |
| sesame absolute | FL/FR |
| sesame absolute CO2 extract | FL/FR |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
2,4,5- | trimethyl thiazole | FL/FR |
onion |
| furfuryl isopropyl sulfide | FL |
popcorn |
2- | propionyl-2-thiazoline | FL |
roasted |
2- | acetyl pyrazine | FL/FR |
roasted arabica | coffee bean oil | FL/FR |
| ethyl 3-(furfuryl thio) propionate | FL |
| furfuryl thioacetate | FL/FR |
| trigonella foenum-graecum seed oil CO2 extract | FL/FR |
solvent |
2- | ethyl furan | FL |
spicy |
para-alpha- | dimethyl styrene | FL/FR |
sulfurous |
2,3- | butane dithiol | FL |
| butyl mercaptan | FL |
| ethyl methyl sulfide | FL |
S- | ethyl thioacetate | FL |
S- | furfuryl thioformate | FL/FR |
| furfuryl thiopropionate | FL |
3- | methyl-2-butane thiol | FL |
| roasted butanol | FL |
2- | thienyl mercaptan | FL |
3- | thiohexanol | FL/FR |
vegetable |
1- | furfuryl pyrrole | FL/FR |
woody |
| juniper berry oleoresin | FL/FR |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
2-[( | furan-2-ylmethyl)sulfanyl]-5-methylpyrazine | 2-( | furan-2-ylmethylsulfanyl)-3-methylpyrazine | ((2- | furanylmethyl)thio)methylpyrazine | 2- | furfuryl thio-3(5/6)methyl pyrazine | 2- | furfuryl thio-5-methyl pyrazine | 2- | furfuryl thio-6-methyl pyrazine | 2- | furfurylthio 3(5/6)methyl pyrazine | 2 | furfurylthio-(3 or 5)-methylpyrazine (2-methyl-3-(furfurylthio)pyrazine) | 2- | furfurylthio-3-methylpyrazine | 2- | furfurylthio-3(5/6)-methyl pyrazine | 2- | furfurylthio-5-methylpyrazine | 2- | furfurylthio-6-methylpyrazine | 2- | methyl-3 or 5 or 6-(furfurylthio)pyrazine (mixture of isomers) | 2- | methyl-3-, 5- or 6-(furfurylthio)pyrazine | 2- | methyl-3-,5 or 6-(furfurylthio) pyrazine | 2- | methyl-3-(furfurylthio)pyrazine | 2- | methyl-3,5 and 6-(furfurylthio)pyrazine | 2- | methyl-3,5 or 6-(furfurylthio)-pyrazine | 2- | methyl-3,5 or 6-(furfurylthio)pyrazine | 2- | methyl-3,5,6-(furfurylthio)pyrazine | 2- | methyl-3(5/6)(furfurylthio) | 2- | methyl-3(or 5 or 6)-(furfurylthio)pyrazine | | pyrazine, ((2-furanylmethyl)thio)methyl- | | pyrazine, 2-((2-furanylmethyl)thio)-3-methyl- |
Articles:
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