CAS Number: | 65620-50-0 | 3D/inchi
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Nikkaji Web: | J1.539.233I |
MDL: | MFCD00238525 |
CoE Number: | 11917 |
XlogP3-AA: | 2.50 (est) |
Molecular Weight: | 212.33268000 |
Formula: | C13 H24 O2 |
NMR Predictor: | Predict (works with chrome or firefox) |
EFSA/JECFA Comments: | (EFFA, 2006k). 46-53 % trans isomer (CASrn 65620-50-0), 44-51 % cis isomer (CASrn 57967-68-7) , 0-2 % Isospiranol (CASrn 54344-69-3)
Specifications (EFFA, 2006; EFFA. 2010). 46-53% trans isomer (CASrn 65620-50-0), 44-51% cis isomer (CASrn 57967-68-7) , 0-2% Isospiranol (CASrn 54344-69-3). |
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless clear liquid (est) |
Assay: | 97.00 to 100.00 % sum of isomers
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 0.99900 to 1.00500 @ 25.00 °C.
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Pounds per Gallon - (est).: | 8.313 to 8.363
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Refractive Index: | 1.48100 to 1.48700 @ 20.00 °C.
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Boiling Point: | 272.00 to 274.00 °C. @ 760.00 mm Hg
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Vapor Pressure: | 0.003000 mmHg @ 25.00 °C. (est) |
Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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logP (o/w): | 2.832 (est) |
Soluble in: |
| alcohol | | water, very slightly | | water, 161 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor Type: herbal |
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| camphoreous pine woody earthy green woody |
Odor Description: at 10.00 % in dipropylene glycol. | camphor pine woody earthy green woody |
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| camphoreous pine earthy green cooling woody |
Odor Description:
| Camphoreous, piney, earthy, green, cooling and woody Mosciano, Gerard P&F 20, No. 4, 23, (1995) |
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Flavor Type: camphoreous |
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| camphoreous woody green cooling minty earthy tropical |
Taste Description: at 20.00 ppm. | Camphoreous, woody, green, cooling and minty with a fenchyl and tropical nuance Mosciano, Gerard P&F 20, No. 4, 23, (1995) |
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Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for 6-hydroxydihydrotheaspirane (mixture of isomers) usage levels up to: | | 0.5000 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.12 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.05 (μg/capita/day) |
Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 6700 (μg/person/day) |
Threshold of Concern: | 540 (μg/person/day) |
Structure Class: | II |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 11 |
Click here to view publication 11 |
| average usual ppm | average maximum ppm |
baked goods: | - | - |
beverages(nonalcoholic): | - | 0.05000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 0.20000 |
fruit ices: | - | - |
gelatins / puddings: | - | 0.20000 |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | - |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | 0.20000 |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
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Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| average usage mg/kg | maximum usage mg/kg |
Dairy products, excluding products of category 02.0 (01.0): | 1.00000 | 10.00000 |
Fats and oils, and fat emulsions (type water-in-oil) (02.0): | - | - |
Edible ices, including sherbet and sorbet (03.0): | 1.00000 | 5.00000 |
Processed fruit (04.1): | - | - |
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
Confectionery (05.0): | 100.00000 | 1000.00000 |
Chewing gum (05.0): | - | - |
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 2.00000 | 4.00000 |
Bakery wares (07.0): | 4.00000 | 6.00000 |
Meat and meat products, including poultry and game (08.0): | 1.00000 | 2.00000 |
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 1.00000 | 2.00000 |
Eggs and egg products (10.0): | - | - |
Sweeteners, including honey (11.0): | - | - |
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 1.00000 | 2.00000 |
Foodstuffs intended for particular nutritional uses (13.0): | - | - |
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 10.00000 | 50.00000 |
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 10.00000 | 50.00000 |
Ready-to-eat savouries (15.0): | 1.00000 | 5.00000 |
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
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For Odor |
No odor group found for these |
3- | benzoyl pyridine | |
| vinyl (4-methyl-thiazolyl-2) carbinol | |
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| octanal propylene glycol acetal | FL/FR |
alliaceous |
| ferula assa-foetida gum oil | FL/FR |
anise |
| fennel fragrance | FR |
balsamic |
dextro- | borneol | FL/FR |
laevo- | borneol | FL/FR |
| bornyl acetate | FL/FR |
iso | bornyl acetate | FL/FR |
| bornyl formate | FL/FR |
iso | bornyl isobutyrate | FL/FR |
iso | bornyl propionate | FL/FR |
dextro- | fenchone | FL/FR |
| fir needle oil siberia | FL/FR |
| valerian rhizome absolute | FL/FR |
camphoreous |
| bornyl ethyl ether | |
beta-homo | cyclocitral | FL/FR |
| fenchol | FL/FR |
laevo- | fenchone | FL/FR |
| hinoki leaf oil | FR |
caramellic |
2-iso | butyl-3-methyl pyrazine | FL/FR |
citrus |
(E+Z)-4,8- | dimethyl-3,7-nonadien-2-yl acetate | FL/FR |
alpha- | methylene citronellal | FR |
| neroli ketone | FR |
| ocimene quintoxide | FL/FR |
coconut |
delta- | heptalactone | FL/FR |
earthy |
5- | cyclopropyl-3(or 2),4-dimethyl octahydro-4,7-methanoinden-5-ol | |
2- | ethyl fenchol | FL/FR |
5- | ethyl-3(or 2),4-dimethyl octahydro-4,7-methanoinden-5-ol | |
(-)-alpha- | fenchol | FL/FR |
1- | nonen-3-ol | FL/FR |
1- | octen-3-ol | FL/FR |
ethereal |
| cyclohexyl formate | FL/FR |
fatty |
| allyl octanoate | FL/FR |
(Z)-3- | octen-1-ol | FL/FR |
floral |
| cyclohexyl ethyl alcohol | FL/FR |
alpha- | damascone | FL/FR |
| dihydrocarvyl acetate | FL/FR |
| geranium dihydropyran | FR |
| linalool oxide | FL/FR |
beta- | ocimene | FL/FR |
| octyl acetate | FL/FR |
| orange leaf absolute | FL/FR |
2- | phenyl propyl acetate | FL/FR |
| rose butanoate | FL/FR |
(R)- | styralyl alcohol | FL/FR |
| ylang ylang flower oil III | FL/FR |
fruity |
| amyl formate | FL/FR |
| apple ketal | FL/FR |
(E)-beta- | damascone | FL/FR |
(E)-alpha- | damascone | FL/FR |
| decen-1-yl cyclopentanone | FL/FR |
2- | pentyl furan | FL/FR |
| propyl hexanoate | FL/FR |
| tropical trithiane | FL/FR |
green |
| bergoxane | FR |
| bicyclogermacrene | |
(S)-2-sec- | butyl-3-methoxypyrazine | |
(R)-2-sec- | butyl-3-methoxypyrazine | |
| cumin acetaldehyde | FL/FR |
iso | cyclocitral (IFF) | FL/FR |
3- | cyclohexyl propyl butyrate | |
alpha,alpha- | dimethyl benzyl alcohol | FL/FR |
alpha- | elemol | FL/FR |
| fern absolute | |
| ferula galbaniflua gum extract | FL/FR |
| fresh nitrile | FR |
| galbanum oil | FL/FR |
| galbanum resinoid | FL/FR |
| galbanum resinoid replacer | FR |
| geranium absolute | FL/FR |
1- | heptanol | FL/FR |
(Z)-3- | hepten-1-ol | FL/FR |
| hexanal (aldehyde C-6) | FL/FR |
(Z)-3- | hexen-1-yl acetoacetate | FL/FR |
(E)-2- | hexen-1-yl salicylate | FR |
(Z)-3- | hexen-1-yl tiglate | FL/FR |
(R)-1- | hexen-3-ol | |
(S)-1- | hexen-3-ol | |
| manzanate (Givaudan) | FL/FR |
para- | methyl hydratropaldehyde | FL/FR |
| octanal dimethyl acetal | FL/FR |
1- | phenyl-2-pentanol | FL/FR |
| rose furan epoxide | FL/FR |
| terpinyl propionate | FL/FR |
3,5,5- | trimethyl hexanol | FL/FR |
2,4,8- | trimethyl-5-oxatricyclo(6.2.1.0*2,6*)undecane | FR |
1,5- | undecadien-4-ol | |
| valerian rhizome oil CO2 extract china | FL/FR |
herbal |
| bornyl salicylate | FR |
| camphene carbinyl acetate | FR |
(+)-alpha- | campholenic aldehyde | FL/FR |
| canarium luzonicum oil | FL/FR |
1,4- | cineole | FL/FR |
| croton catatii leaf oil | FR |
iso | dihydrolavandulal | FL/FR |
| dimethyl cyclormol (IFF) | FR |
| geranic oxide | FL/FR |
| hyssop oil | FL/FR |
| myrtenol | FL/FR |
| pine hexanol | FR |
alpha- | pinene | FL/FR |
| pinocarveol | FL/FR |
| piperitone | FL/FR |
| rosemary absolute | FL/FR |
| sabinene hydrate | FL/FR |
| sage oleoresin | FL/FR |
| theaspirane | FL/FR |
| tricyclo(5.2.1.02,6)dec-3-enyl acetate | FR |
| valerian rhizome oil | FL/FR |
melon |
(Z)-6- | nonenal | FL/FR |
mentholic |
| cornmint oil | FL/FR |
| cornmint oil china | FL/FR |
dextro,laevo- | menthol | FL/FR |
(±)-iso | menthone | FL/FR |
| peppermint cyclohexanone | FL/FR |
dextro- | piperitone | FL/FR |
minty |
dextro- | dihydrocarvone | FL/FR |
trans-para- | menthan-2-one | FL/FR |
homo | menthol | FL/FR |
homo | menthyl acetate | FL/FR |
| pennyroyal oil | FL/FR |
| pennyroyal oil fractions | FL/FR |
| peppermint absolute | FL/FR |
| peppermint fragrance | FR |
| peppermint oil america | FL/FR |
| peppermint oil idaho | FL/FR |
| peppermint oil special fractions | FL/FR |
| peppermint oil willamette | FL/FR |
laevo- | piperitone | FL/FR |
iso | propyl tiglate | FL/FR |
(-)-iso | pulegol | FL/FR |
iso | pulegol | FL/FR |
| spearmint oil america | FL/FR |
mossy |
| oakmoss absolute | FL/FR |
nutty |
5- | ethyl-4-methyl thiazole | |
orris |
iso | eugenyl formate | FL/FR |
spicy |
| caryophyllene | FL/FR |
beta- | caryophyllene | FL/FR |
iso | cyclogeraniol (IFF) | FR |
| myrtenal | FL/FR |
2- | octanol | FL/FR |
| tea tree oil | FR |
| mango thiol | FL/FR |
tropical |
2- | tropical oxathiane | FL/FR |
waxy |
| nonyl acetate | FL/FR |
| octyl isobutyrate | FL/FR |
woody |
iso | bornyl isovalerate | FL/FR |
beta- | cadinene | |
| camphene | FL/FR |
(+)- | camphene | FL/FR |
| dihydro-beta-ionone | FL/FR |
3(or 2),4- | dimethyl-5-vinyl octahydro-4,7-methanoinden-5-ol | |
5,5a,6,7,8,8a- | hexahydro-6,6,7,8,8-pentamethyl-4H-indeno[5,4-D]isoxazole | |
6- | methoxy-1,6,7-trimethyl octahydro-4,7-methanoindene + 5-methoxy-2,4,5-trimethyl octahydro-4,7-methan | |
beta- | terpineol | FL/FR |
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For Flavor |
|
No flavor group found for these |
| benzyl disulfide | FL |
| bicyclogermacrene | |
dextro- | borneol | FL/FR |
| bornyl formate | FL/FR |
(R)-2-sec- | butyl-3-methoxypyrazine | |
(S)-2-sec- | butyl-3-methoxypyrazine | |
beta- | cadinene | |
(+)- | camphene | FL/FR |
3- | cyclohexyl propyl butyrate | |
5- | cyclopropyl-3(or 2),4-dimethyl octahydro-4,7-methanoinden-5-ol | |
alpha,alpha- | dimethyl benzyl alcohol | FL/FR |
(E+Z)-4,8- | dimethyl-3,7-nonadien-2-yl acetate | FL/FR |
3(or 2),4- | dimethyl-5-vinyl octahydro-4,7-methanoinden-5-ol | |
alpha- | elemol | FL/FR |
5- | ethyl-3(or 2),4-dimethyl octahydro-4,7-methanoinden-5-ol | |
5- | ethyl-4-methyl thiazole | |
iso | eugenyl formate | FL/FR |
| fern absolute | |
(Z)-3- | hepten-1-ol | FL/FR |
5,5a,6,7,8,8a- | hexahydro-6,6,7,8,8-pentamethyl-4H-indeno[5,4-D]isoxazole | |
(Z)-3- | hexen-1-yl acetoacetate | FL/FR |
(S)-1- | hexen-3-ol | |
(R)-1- | hexen-3-ol | |
6- | methoxy-1,6,7-trimethyl octahydro-4,7-methanoindene + 5-methoxy-2,4,5-trimethyl octahydro-4,7-methan | |
| octanal propylene glycol acetal | FL/FR |
2- | phenyl propyl acetate | FL/FR |
| rose furan epoxide | FL/FR |
(R)- | styralyl alcohol | FL/FR |
beta- | terpineol | FL/FR |
1,5- | undecadien-4-ol | |
alliaceous |
| ferula assa-foetida gum oil | FL/FR |
balsamic |
iso | bornyl isobutyrate | FL/FR |
iso | bornyl propionate | FL/FR |
| fir needle oil siberia | FL/FR |
camphoreous |
laevo- | borneol | FL/FR |
| bornyl acetate | FL/FR |
| bornyl ethyl ether | |
| camphene | FL/FR |
| fenchol | FL/FR |
(-)-alpha- | fenchol | FL/FR |
laevo- | fenchone | FL/FR |
| geranic oxide | FL/FR |
| pinocarveol | FL/FR |
cooling |
1,4- | cineole | FL/FR |
beta-homo | cyclocitral | FL/FR |
dextro- | fenchone | FL/FR |
| manzanate (Givaudan) | FL/FR |
dextro,laevo- | menthol | FL/FR |
homo | menthyl acetate | FL/FR |
| peppermint oil america | FL/FR |
| sabinene hydrate | FL/FR |
| theaspirane | FL/FR |
| WS-3 | FL |
creamy |
| octyl isobutyrate | FL/FR |
earthy |
2- | ethyl fenchol | FL/FR |
1- | nonen-3-ol | FL/FR |
fatty |
| allyl octanoate | FL/FR |
(Z)-3- | octen-1-ol | FL/FR |
floral |
| dihydrocarvyl acetate | FL/FR |
| orange leaf absolute | FL/FR |
| ylang ylang flower oil III | FL/FR |
fruity |
| amyl formate | FL/FR |
| apple ketal | FL/FR |
alpha- | damascone | FL/FR |
(E)-alpha- | damascone | FL/FR |
(E)-beta- | damascone | FL/FR |
| decen-1-yl cyclopentanone | FL/FR |
1- | phenyl-2-pentanol | FL/FR |
| propyl hexanoate | FL/FR |
| rose butanoate | FL/FR |
| tropical trithiane | FL/FR |
| valerian rhizome absolute | FL/FR |
| valerian rhizome oil | FL/FR |
| valerian rhizome oil CO2 extract china | FL/FR |
green |
3- | benzoyl pyridine | |
2-iso | butyl-3-methyl pyrazine | FL/FR |
(+)-alpha- | campholenic aldehyde | FL/FR |
| canarium luzonicum oil | FL/FR |
| cumin acetaldehyde | FL/FR |
iso | cyclocitral (IFF) | FL/FR |
| cyclohexyl ethyl alcohol | FL/FR |
| cyclohexyl formate | FL/FR |
dextro- | dihydrocarvone | FL/FR |
| ferula galbaniflua gum extract | FL/FR |
| galbanum oil | FL/FR |
| galbanum resinoid | FL/FR |
| geranium absolute | FL/FR |
| hexanal (aldehyde C-6) | FL/FR |
(Z)-3- | hexen-1-yl tiglate | FL/FR |
| horseradish oil | FL |
| linalool oxide | FL/FR |
para- | methyl hydratropaldehyde | FL/FR |
(Z)-6- | nonenal | FL/FR |
| oakmoss absolute | FL/FR |
beta- | ocimene | FL/FR |
| ocimene quintoxide | FL/FR |
| octanal dimethyl acetal | FL/FR |
2- | pentyl furan | FL/FR |
iso | phorone | FL |
iso | propyl tiglate | FL/FR |
| propylene glycol acetone ketal | FL |
| terpinyl propionate | FL/FR |
3,5,5- | trimethyl hexanol | FL/FR |
herbal |
iso | dihydrolavandulal | FL/FR |
| hyssop oil | FL/FR |
| oregano oleoresin | FL |
| rosemary absolute | FL/FR |
| sage oleoresin | FL/FR |
lactonic |
delta- | heptalactone | FL/FR |
mentholic |
| cornmint oil | FL/FR |
| peppermint cyclohexanone | FL/FR |
minty |
| cornmint oil china | FL/FR |
trans-para- | menthan-2-one | FL/FR |
homo | menthol | FL/FR |
(±)-iso | menthone | FL/FR |
| mint flavor | FL |
| myrtenal | FL/FR |
| myrtenol | FL/FR |
| pennyroyal oil | FL/FR |
| pennyroyal oil fractions | FL/FR |
| peppermint absolute | FL/FR |
| peppermint flavor | FL |
| peppermint oil idaho | FL/FR |
| peppermint oil special fractions | FL/FR |
| peppermint oil willamette | FL/FR |
laevo- | piperitone | FL/FR |
| piperitone | FL/FR |
dextro- | piperitone | FL/FR |
(-)-iso | pulegol | FL/FR |
iso | pulegol | FL/FR |
| spearmint oil america | FL/FR |
mushroom |
1- | octen-3-ol | FL/FR |
nutty |
| peanut oxazole | FL |
solvent |
1- | heptanol | FL/FR |
spicy |
beta- | caryophyllene | FL/FR |
| caryophyllene | FL/FR |
| galanga flavor | FL |
2- | octanol | FL/FR |
sulfurous |
| mango thiol | FL/FR |
| methyl 2-(methyl thio) butyrate | FL |
terpenic |
para- | menthatriene | FL |
tropical |
2- | tropical oxathiane | FL/FR |
waxy |
| nonyl acetate | FL/FR |
| octyl acetate | FL/FR |
woody |
iso | bornyl acetate | FL/FR |
iso | bornyl isovalerate | FL/FR |
| dihydro-beta-ionone | FL/FR |
alpha- | pinene | FL/FR |
| vinyl (4-methyl-thiazolyl-2) carbinol | |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| herbal spirane | 6- | hydroxy-2,6,10,10-tetramethyl-1-oxaspiro-4,5-decane (mixture of isomers) | 6- | hydroxy-2,6,10,10-tetramethyl-1-oxaspiro[4.5]decane (mixture of isomers) | 1-oxa | spiro(4.5)decan-6-ol, 2,6,10,10-tetramethyl- | 1-oxa | spiro[4.5]decan-6-ol, 2,6,10,10-tetramethyl- | 2,6,10,10- | tetramethyl-1-oxaspiro(4.5)decan-6-ol | 2,6,10,10- | tetramethyl-1-oxaspiro[4.5]decan-6-ol |
Articles:
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