Flavor Demo Formulas |
CAS Number: | 55031-15-7 | 3D/inchi
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Other(deleted CASRN): | 55031-15-7 |
FDA UNII: | 1D80F4PE6E |
MDL: | MFCD00047392 |
CoE Number: | 727 |
Molecular Weight: | 272.39528000 |
Formula: | C16 H24 N4 |
NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Also(can) Contains: | 3,6-cocoa pyrazine |
| 3,5-cocoa pyrazine |
EFSA/JECFA Comments: | JECFA evaluated 2-ethyl-3 (5 or 6)-dimethylpyrazine (CASrn 13360-65-1, 13925-07-0).
Mixture of positional isomers (2-Ethyl-3,5/6-dimethyl-), 2-ethyl-3,5-dimethylpyrazine (50-57 %); 2-ethyl-3,6-dimethylpyrazine (43-50 %) (EFFA, 2010a).
JECFA CASrn: (13360-65-1, 13925-07-0). |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to pale yellow clear liquid (est) |
Assay: | 95.00 to 100.00 %
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Food Chemicals Codex Listed: | No |
Specific Gravity: | 0.96500 @ 25.00 °C.
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Melting Point: | 64.00 to 66.00 °C. @ 8.00 mm Hg
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Boiling Point: | 180.00 to 182.00 °C. @ 760.00 mm Hg
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Vapor Density: | 4.6 ( Air = 1 ) |
Flash Point: | 157.00 °F. TCC ( 69.44 °C. )
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Soluble in: |
| water |
Stability: |
| stable in most media |
Organoleptic Properties:
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Odor Type: nutty |
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Odor Strength: | high , recommend smelling in a 1.00 % solution or less |
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Substantivity: | 5 hour(s) at 100.00 % |
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| nutty nut skin hazelnut peanut chocolate roasted |
Odor Description: at 1.00 % in dipropylene glycol. | nutty nut skin hazelnut peanut chocolate roasted Luebke, William tgsc, (2009) |
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| nut skin brown sweet musty peanut roasted peanut |
Odor Description:
| Nut skin, brown, sweet, musty, with a slightly roasted peanut shell nuance Mosciano, Gerard P&F 17, No. 3, 57, (1992) |
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Flavor Type: nutty |
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| peanut nut skin brown hazelnut roasted hazelnut coffee chocolate |
Taste Description: at 5.00 ppm. | Peanut, nut skin, brown, roasted, hazelnut, with coffee and chocolate nuances Mosciano, Gerard P&F 17, No. 3, 57, (1992) |
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Odor and/or flavor descriptions from others (if found). |
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Sigma-Aldrich |
2-Ethyl-3(5 or 6)-dimethylpyrazine, mixture of isomers, ≥95%, FG |
Odor Description: | almond; beef; caramel; cheese; corn; coffee; earthy; woody; tobacco. |
Taste Description: | peanut nut skin brown roasted hazelnut coffee chocolate |
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R C Treatt & Co Ltd |
2-Ethyl-3(5/6)-dimethylpyrazine Halal, Kosher |
Odor Description: | roast nuts/almonds, cocoa/coffee, woody/potato crisps |
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Pell Wall Perfumes |
Cocoa Pyrazine |
Odor Description: | chocolate, cocoa, nutty-hazelnut and peanut, roasted As with all pyrazines this is used in traces – Cocoa Pyrazine at 0.1% in PG has a distinctively chocolate and cocoa powder odour with elements of roasted nuts.
Occurs in various nuts, asparagus, tea and tobacco as well as chocolate. Even at 0.1% this is a very powerful material that can easily dominate your blend, so use with caution. |
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Cosmetic Information:
Suppliers:
Ambles Nature et Chimie |
2-ETHYL-3(5or6)-DIMETHYL PYRAZINE
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Augustus Oils |
Cocoa Pyrazine 10% Pg
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Services |
BOC Sciences |
For experimental / research use only. |
2-Ethyl-3,5-dimethylpyrazine 98%
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Charkit Chemical |
COCOA PYRAZINE 10% IN PG
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Charkit Chemical |
DIMETHYL ETHYL PYRAZINE NATURAL FEMA 3149
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Charkit Chemical |
ETHYL-3(5/6)-DIMETHYLPYRAZINE, 2- FEMA 3149
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Endeavour Specialty Chemicals |
2-Ethyl-3,5(6)-dimethylpyrazine 99% F&F
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Speciality Chemical Product Groups |
Ernesto Ventós |
2-ETHYL-3(5 OR 6)-DIMETHYLPYRAZINE
Odor: NUTTY, EARTHY, WOODY |
FCI SAS |
2-ETHYL-3, 5(6)-DIMETHYL PYRAZINE
Odor: Chocolate, coffee, nut |
Indukern F&F |
2-ETHYL-3,5(6)-DIMETHYL PYRAZINE
Odor: POTATO, CACAO, NUTTY, TOASTED |
Kingchem Laboratories |
2 ETHYL-3(5 or 6) DIMETHYLPYRAZINE
Odor: Chocolate, coffee, nut |
Lluch Essence |
PYRAZINE 2-ETHYL-3,5(6)-DIMETHYL
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M&U International |
2-ETHYL-3(5/6)-DIMETHYLPYRAZINE, Kosher
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Myrazine |
2-Ethyl-3,5 (or 6)-dimethyl pyrazine/EU Nat.
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Pell Wall Perfumes |
Cocoa Pyrazine 1%
Odor: chocolate, cocoa, nutty-hazelnut and peanut, roasted Use: As with all pyrazines this is used in traces – Cocoa Pyrazine at 1% in Ethanol has a strong, distinctively chocolate and cocoa powder odour with elements of roasted nuts. |
Pell Wall Perfumes |
Cocoa Pyrazine
Odor: chocolate, cocoa, nutty-hazelnut and peanut, roasted Use: As with all pyrazines this is used in traces – Cocoa Pyrazine at 0.1% in PG has a distinctively chocolate and cocoa powder odour with elements of roasted nuts.
Occurs in various nuts, asparagus, tea and tobacco as well as chocolate. Even at 0.1% this is a very powerful material that can easily dominate your blend, so use with caution. |
Phoenix Aromas & Essential Oils |
Pyrazine, 2-Ethyl-3, 5(6)-Dimethyl
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R C Treatt & Co Ltd |
2-Ethyl-3(5/6)-dimethylpyrazine
Halal, Kosher Odor: roast nuts/almonds, cocoa/coffee, woody/potato crisps |
R C Treatt & Co Ltd |
Cocoa Pyrazine 10% In Pg
Halal, Kosher |
Reincke & Fichtner |
2-Ethyl-3,(5 or 6)-dimethylpyrazine
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Riverside Aromatics |
ETHYLDIMETHYLPYRAZINES FRACTION, NATURAL
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Sigma-Aldrich |
2-Ethyl-3(5 or 6)-dimethylpyrazine, mixture of isomers, ≥95%, FG
Odor: almond; beef; caramel; cheese; corn; coffee; earthy; woody; tobacco. |
Certified Food Grade Products |
Sunaux International |
2-Ethyl-3(5/6)-dimethyl Pyrazine
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Synerzine |
2-ETHYL-3,(5 or 6)-DIMETHYLPYRAZINE MIXTURE, NATURAL
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Synerzine |
coco pyrazines mixture in p.g.
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Synerzine |
DIMETHYLETHYL PYRAZINE, NATURAL
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United International |
2-Ethyl-3,5(6)-Dimethyl Pyrazine
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WholeChem |
2-Ethyl-3(5 & 6)dimethylpyrazine
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 22 - Harmful if swallowed. R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
gavage-rat LD50 456 mg/kg (Moran et al., 1980)
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavoring agents |
Recommendation for 3,5(6)-cocoa pyrazine usage levels up to: | | not for fragrance use.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 38.00 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 9.00 (μg/capita/day) |
Structure Class: | II |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 4 |
Click here to view publication 4 |
| average usual ppm | average maximum ppm |
baked goods: | - | 5.00000 |
beverages(nonalcoholic): | - | 5.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | 2.00000 |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | 2.00000 |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | - |
fruit ices: | - | - |
gelatins / puddings: | - | 2.00000 |
granulated sugar: | - | - |
gravies: | - | 2.00000 |
hard candy: | - | 5.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | 2.00000 |
milk products: | - | 1.00000 |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s): |
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf |
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010) View page or View pdf |
Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species View page or View pdf |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 55031-15-7 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 16220104 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 3 |
| 2-ethyl-3,5-dimethylpyrazine; 3-ethyl-2,5-dimethylpyrazine |
Chemidplus: | 0027043056 |
References:
Other Information:
Potential Blenders and core components note
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For Odor |
No odor group found for these |
| sulfuryl octanoate | FL/FR |
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
| sulfuryl propionate | FL/FR |
balsamic |
| propyl benzoate | FL/FR |
caramellic |
| ethyl 2-hydroxy-2-methyl butyrate | FL/FR |
chocolate |
| chocolate pyrazine A | FL/FR |
2- | methoxy-3-methyl pyrazine | FL/FR |
cocoa |
2- | methyl butyraldehyde | FL/FR |
earthy |
2- | ethyl-3-methoxypyrazine | FL/FR |
fermented |
| valeraldehyde | FL/FR |
2- | heptyl furan | FL/FR |
(E,Z)-2,6- | nonadien-1-yl acetate | FL/FR |
herbal |
black | camellia sinensis leaf infusion | FL/FR |
naphthyl |
para- | methyl anisole | FL/FR |
nutty |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
3,6- | cocoa pyrazine | FL/FR |
2,3- | dimethyl pyrazine | FL/FR |
| filbert heptenone | FL/FR |
2- | methyl pyrazine | FL/FR |
2- | methyl-3-propyl pyrazine | FL/FR |
2,4,5- | trimethyl oxazole | FL/FR |
2,3,5- | trimethyl pyrazine | FL/FR |
popcorn |
2- | acetyl thiazole | FL/FR |
tobacco |
3- | ethyl pyridine | FL/FR |
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For Flavor |
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No flavor group found for these |
| butyramide | FL |
| chocolate pyrazine A | FL/FR |
| chocolate pyrazine B | FL |
| cyclohexyl methyl pyrazine | FL |
2,5- | diethyl thiazole | FL |
2,5- | diethyl-4-methyl thiazole | FL |
6,7- | dihydro-2,3-dimethyl-5H-cyclopentapyrazine | FL |
2,5- | dimethyl thiazole | FL |
| ethyl 2-hydroxy-2-methyl butyrate | FL/FR |
2- | ethyl-3-methoxypyrazine | FL/FR |
| methyl 2-(methyl thio) acetate | FL |
2- | propyl pyridine | FL |
para- | salicylic acid | FL |
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
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| sulfuryl octanoate | FL/FR |
| sulfuryl propionate | FL/FR |
bitter |
| methyl ethoxypyrazine | FL |
brown |
| juglans nigra shell extract | FL |
burnt |
2,4,5- | trimethyl oxazole | FL/FR |
caramellic |
3- | ethyl pyridine | FL/FR |
cocoa |
| cacao flavor | FL |
coffee |
roasted | coffee bean concentrate | FL |
| coffee enhancers | FL |
| coffee flavor | FL |
| difurfuryl ether | FL |
2-iso | propyl pyrazine | FL |
corn chip |
2- | acetyl thiazole | FL/FR |
2- | acetyl-2-thiazoline | FL |
earthy |
2- | methyl-3-propyl pyrazine | FL/FR |
fatty |
2- | heptyl furan | FL/FR |
fruity |
| propyl benzoate | FL/FR |
fusel |
2- | methyl butyraldehyde | FL/FR |
green |
| dihydroxyacetophenone (mixed isomers) | FL |
2- | methyl-5-isopropyl pyrazine | FL |
(E,Z)-2,6- | nonadien-1-yl acetate | FL/FR |
2- | vinyl pyrazine | FL |
herbal |
black | camellia sinensis leaf infusion | FL/FR |
musty |
2,3,5- | trimethyl pyrazine | FL/FR |
naphthyl |
para- | methyl anisole | FL/FR |
nutty |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
3,6- | cocoa pyrazine | FL/FR |
2,3- | dimethyl pyrazine | FL/FR |
1- | ethyl-2-acetyl pyrrole | FL |
2- | ethyl-6-methyl pyrazine | FL |
| filbert heptenone | FL/FR |
2- | methoxy-3-methyl pyrazine | FL/FR |
2- | methyl pyrazine | FL/FR |
roasted |
| acer spicatum bark extract | FL |
| gluconyl ethanolamine | FL |
| lactoyl ethanolamine phosphate | FL |
spicy |
| cinnamon hazelnut cappuccino flavor | FL |
winey |
| valeraldehyde | FL/FR |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
3,5(6)- | dimethyl-2-ethyl pyrazine mixture | 3,(5- or 6)- | dimethyl-2-ethylpyrazine | 3,5(6)- | dimethyl-2-ethylpyrazine mixture | | ethyl dimethyl pyrazine natural | | ethyl-(3,5 or 6)-methoxypyrazine (85%) and 2-methyl-(3,5 or 6)-methoxypyrazine (13%) | | ethyl-3,(5 or 6)-dimethyl pyrazine | | ethyl-3,(5 or 6)-dimethylpyrazine | 2- | ethyl-3,(5 or 6)-dimethylpyrazine | 2- | ethyl-3,5-dimethylpyrazine; 3-ethyl-2,5-dimethylpyrazine | 2- | ethyl-3,5(6)-dimethyl pyrazine | 2- | ethyl-3,5(6)-dimethyl pyrazine mixture | 2- | ethyl-3,5(6)-dimethylpyrazine | 2- | ethyl-3,5(6)-dimethylpyrazine mixture | 2- | ethyl-3,5{6}-dimethyl pyrazine | 2 | ethyl-3(5 or 6) dimethylpyrazine | 2- | ethyl-3(5 or 6)-dimethylpyrazine | 2- | ethyl-3(5/6)-dimethylpyrazine | | pyrazine, 2-ethyl-3, 5(6)-dimethyl |
Articles:
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