Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to pale yellow clear liquid (est) |
Assay: | 98.00 to 100.00 %
|
Additional Assay Information: | sum of 2,3- 2,5- and 2,6- isomers |
Food Chemicals Codex Listed: | Yes |
Specific Gravity: | 0.98000 to 1.00000 @ 25.00 °C.
|
Pounds per Gallon - (est).: | 8.155 to 8.321
|
Refractive Index: | 1.49700 to 1.50100 @ 20.00 °C.
|
Melting Point: | 15.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 154.00 to 156.00 °C. @ 760.00 mm Hg
|
Vapor Pressure: | 3.980000 mmHg @ 25.00 °C. (est) |
Vapor Density: | 3.7 ( Air = 1 ) |
Flash Point: | 130.00 °F. TCC ( 54.44 °C. )
|
logP (o/w): | 0.630 |
Soluble in: |
| alcohol | | water, 3.197e+004 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
|
Odor Type: chocolate |
|
| cocoa roasted nutty beefy roasted beefy woody grassy medicinal |
Odor Description: at 0.10 % in dipropylene glycol. | cocoa roasted nuts roast beef woody grass medical |
|
| nutty peanut musty earthy powdery roasted cocoa |
Odor Description:
| Nutty, peanut, musty, earthy, powdery and slightly roasted with a cocoa powder nuance Mosciano, Gerard P&F 21, No. 6, 49, (1996) |
|
|
Flavor Type: musty |
|
| musty potato cocoa nutty fatty oily |
Taste Description: at 7.50 ppm. | Musty, potato, cocoa and nutty with a fatty and oily nuance Mosciano, Gerard P&F 21, No. 6, 49, (1996) |
|
Odor and/or flavor descriptions from others (if found). |
|
Bedoukian Research |
2,5-DIMETHYL PYRAZINE ≥99.0%, Kosher |
Odor Description: | cocoa, roasted nut, roast beef, woody Could be used very sparingly in appropriate applications. |
Taste Description: | cocoa Used in potato, beer and chicken flavors as well as those needing fried notes. |
|
Kingchem Laboratories |
2, 5 DIMETHYLPYRAZINE |
Odor Description: | Roast, coffee, peanut and meat |
|
Advanced Biotech |
2,5 DIMETHYL PYRAZINE NATURAL 90% min. (mixed isomers) |
Odor Description: | Chocolate, roasted nuts |
|
Advanced Biotech |
2,5 DIMETHYL PYRAZINE |
Odor Description: | Chocolate, Nutty, Roasted |
|
Pell Wall Perfumes |
Ketine (Pyrazine) |
Odor Description: | chocolate, cocoa, roasted-nuts, woody, slightly green-grass According to Arctander the main use of this material was to scent the packets and enhance the flavour of potato crisps / chips.
It is present in the scent of coffee and chocolate but also some types of lavender, beer and pork. It also has a green-grass aspect that can add depth to green scents, in high dilution. |
|
Advanced Biotech |
2 5 DIMETHYL PYRAZINE (W TYPE) NATURAL |
Odor Description: | Chocolate, Roasted Nut |
|
|
Cosmetic Information:
Suppliers:
Advanced Biotech |
2 5 DIMETHYL PYRAZINE (W TYPE) NATURAL
Odor: Chocolate, Roasted Nut |
Advanced Biotech |
2,5 DIMETHYL PYRAZINE NATURAL
90% min. (mixed isomers) Odor: Chocolate, roasted nuts |
Advanced Biotech |
2,5 DIMETHYL PYRAZINE
Odor: Chocolate, Nutty, Roasted |
Advanced Biotech |
2,5(6) DIMETHYL PYRAZINE NATURAL
|
Ambles Nature et Chimie |
2.5 DIMETHYL NAT
|
Anhui Haibei |
2,5-Dimethyl Pyrazine
Odor: Cocoa roasted nuts roast beef woody grass medical |
Augustus Oils |
2,5 Dimethyl Pyrazine
|
Services |
Beijing Lys Chemicals |
2,5-Dimethyl pyrazine
|
BOC Sciences |
For experimental / research use only. |
2,5-Dimethylpyrazine
|
Charkit Chemical |
DIMETHYLPYRAZINE, 2,5- FEMA 3272
|
CJ Latta & Associates |
2,5-DIMETHYL PYRAZINE
|
DeLong Chemicals America |
2,5-Dimethylpyrazine, Kosher
|
Diffusions Aromatiques |
2,5-DIMETHYL PYRAZINE
|
EMD Millipore |
For experimental / research use only. |
2,5-Dimethylpyrazine
|
Endeavour Specialty Chemicals |
2,5-Dimethyl pyrazine
|
Speciality Chemical Product Groups |
Ernesto Ventós |
2,5-DIMETHYLPYRAZINE
Odor: RAW POTATO, ROASTED, EARTHY |
Excellentia International |
2,5-Dimethyl Pyrazine (Pyrazine Mix. # 10, 12, 16, 20) Natural
|
FCI SAS |
2,5-DIMETHYL PYRAZINE
Odor: Roast, coffee, peanut and meat |
Fleurchem |
2,5-dimethyl pyrazine
|
Fleurchem |
dimethyl pyrazine natural
|
Frutarom |
2,5-DIMETHYLPYRAZINE
KOSHER Flavor: Musty, Oily, Nutty, Roasted |
CBD Offering |
IFF |
2,5-DIMETHYLPYRAZINE
KOSHER Flavor: Musty, Oily, Nutty, Roasted |
Indukern F&F |
2,5-DIMETHYL PYRAZINE
Odor: EARTHY, POTATO |
Jiangyin Healthway |
2,5-Dimethyl Pyrazine
|
New functional food ingredients |
Jinan Enlighten Chemical Technology(Wutong Aroma ) |
2,5-Dimethyl pyrazine, Kosherk
|
Kingchem Laboratories |
2, 5 DIMETHYLPYRAZINE
Odor: Roast, coffee, peanut and meat |
Lluch Essence |
PYRAZINE 2,5-DIMETHYL
|
M&U International |
2,5-DIMETHYL PYRAZINE, Kosher
|
M&U International |
Nat. 2,5-Dimethyl Pyrazine
|
Moellhausen |
2,5-DIMETHYL PYRAZINE (10%DPG)
|
Moellhausen |
2,5-DIMETHYL PYRAZINE
Odor: coffee, nut, cocoa Flavor: nut, fat, cocoa, potato |
Myrazine |
2,5-Dimethylpyrazine/EU Nat.
Odor: cocoa roasted nuts roast beef woody grass medical |
Myrazine |
Pyrazine, 2,5-dimethyl-
Odor: cocoa roasted nuts roast beef woody grass medical |
OQEMA |
2,5-Dimethyl Pyrazine
|
Pearlchem Corporation |
2,5-Dimethyl Pyrazine
|
Pell Wall Perfumes |
Ketine (Pyrazine)
Odor: chocolate, cocoa, roasted-nuts, woody, slightly green-grass Use: According to Arctander the main use of this material was to scent the packets and enhance the flavour of potato crisps / chips.
It is present in the scent of coffee and chocolate but also some types of lavender, beer and pork. It also has a green-grass aspect that can add depth to green scents, in high dilution. |
Penta International |
2,5-DIMETHYL PYRAZINE NATURAL
|
Penta International |
2,5-DIMETHYL PYRAZINE
|
Phoenix Aromas & Essential Oils |
Pyrazine, 2,5-Dimethyl
|
R C Treatt & Co Ltd |
2,5-Dimethylpyrazine
Halal, Kosher |
Reincke & Fichtner |
2,5-Dimethylpyrazine
|
Riverside Aromatics |
2,5-DIMETHYLPYRAZINE
|
Robinson Brothers |
2,5-Dimethyl pyrazine F&F
|
https://www.robinsonbrothers.uk/chemistry-competences |
Santa Cruz Biotechnology |
For experimental / research use only. |
2,5-Dimethylpyrazine
|
Sigma-Aldrich |
2,5-Dimethylpyrazine, ≥98%, FCC, FG
Odor: meaty; medicinal; nutty; woody. |
Certified Food Grade Products |
Sunaux International |
2,5-Dimethyl Pyrazine
|
Synerzine |
2,5-DIMETHYLPYRAZINE MIXTURE (NATU
|
Synerzine |
2,5-Dimethylpyrazine
97% min (Flavor grade) |
Synerzine |
2,5-Dimethylpyrazine
99% min (Research grade) |
Synerzine |
natural 2,5-Dimethylpyrazine
|
Taytonn ASCC |
2,5-Dimethylpyrazine
Odor: Grass, Green, Nutty, Roast, Woody |
TCI AMERICA |
For experimental / research use only. |
2,5-Dimethylpyrazine >98.0%(GC)(T)
|
Tengzhou Jitian Aroma Chemiclal |
2,5-Dimethyl Pyrazine
|
Tengzhou Xiang Yuan Aroma Chemicals |
2,5-Dimethyl Pyrazine
|
Tianjin Danjun International |
2,5-Dimethylpyrazine
|
United International |
2,5-Dimethyl Pyrazine Nat.
|
United International |
2,5-Dimethyl Pyrazine
|
Vigon International |
DIMETHYL-2,5 PYRAZINE NATURAL
|
Vigon International |
Dimethyl-2,5 Pyrazine
|
WholeChem |
2.5-Dimethyl pyrazine
|
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 22 - Harmful if swallowed. R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
|
|
Hazards identification |
|
Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
|
Pictogram | |
|
Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
gavage-rat LD50 1020 mg/kg (Moran et al., 1980)
intraperitoneal-mouse LD50 1350 mg/kg Toxicology and Applied Pharmacology. Vol. 17, Pg. 244, 1970.
oral-rat LD50 1020 mg/kg Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980.
|
Dermal Toxicity: |
Not determined
|
Inhalation Toxicity: |
Not determined
|
Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for 2,5-dimethyl pyrazine usage levels up to: | | 0.1000 % in the fragrance concentrate.
|
|
Maximised Survey-derived Daily Intakes (MSDI-EU): | 19.00 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 8.00 (μg/capita/day) |
Structure Class: | II |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 5 |
Click here to view publication 5 |
| average usual ppm | average maximum ppm |
baked goods: | - | 10.00000 |
beverages(nonalcoholic): | - | 10.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | 10.00000 |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 10.00000 |
fruit ices: | - | 10.00000 |
gelatins / puddings: | - | 10.00000 |
granulated sugar: | - | - |
gravies: | - | 10.00000 |
hard candy: | - | 10.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | 10.00000 |
milk products: | - | 10.00000 |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | 10.00000 |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s): |
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf |
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010) View page or View pdf |
Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species View page or View pdf |
EPI System: | View |
Chemical Carcinogenesis Research Information System: | Search |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 123-32-0 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 31252 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 3 |
| 2,5-dimethylpyrazine |
Chemidplus: | 0000123320 |
RTECS: | UQ2800000 for cas# 123-32-0 |
References:
Other Information:
Potential Blenders and core components note
|
For Odor |
No odor group found for these |
| sulfuryl octanoate | FL/FR |
|
| butyl decanoate | FL/FR |
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
| sulfuryl propionate | FL/FR |
aldehydic |
10- | undecenal (aldehyde C-11 undecylenic) | FL/FR |
balsamic |
| guaiacyl phenyl acetate | FL/FR |
| guaiyl acetate | FL/FR |
bready |
| coffee furanone | FL/FR |
| furfural | FL/FR |
| rum ether | FL/FR |
caramellic |
| ethyl cyclopentenolone | FL/FR |
| fenugreek absolute | FL/FR |
| maltol | FL/FR |
iso | propenyl pyrazine | FL/FR |
| shoyu furanone | FL/FR |
| toffee furanone | FL/FR |
| chocolate pyrazine A | FL/FR |
| cocoa hexenal | FL/FR |
2,4,5- | trimethyl thiazole | FL/FR |
cocoa |
| theobroma cacao extract | FL/FR |
earthy |
2- | ethyl-3-methoxypyrazine | FL/FR |
| nutty pyrazine | FL/FR |
(Z)- | oleic acid | FL/FR |
fermented |
iso | amyl alcohol | FL/FR |
| methyl decanoate | FL/FR |
floral |
| champaca absolute | FR |
| dimethyl benzyl carbinyl propionate | FR |
| geranyl formate | FL/FR |
alpha-iso | methyl ionone (90% min.) | FL/FR |
| phenethyl isobutyrate | FL/FR |
| tea acetate | FR |
| tetrahydrolinalool | FL/FR |
fruity |
| heptyl butyrate | FL/FR |
(E)-7- | methyl-3-octen-2-one | FL/FR |
1- | heptanol | FL/FR |
2- | heptyl furan | FL/FR |
| magnolia flower oil | FL/FR |
(E,Z)-2,6- | nonadien-1-ol | FL/FR |
(E,Z)-2,6- | nonadien-1-yl acetate | FL/FR |
2- | octen-1-ol | FL/FR |
(E)-2- | octen-1-ol | FL/FR |
herbal |
6- | acetoxydihydrotheaspirane | FL/FR |
| clary sage absolute | FL/FR |
| clary sage oil france | FL/FR |
licorice |
sweet | basil oleoresin | FL/FR |
| sulfurol | FL/FR |
| sulfuryl acetate | FL/FR |
minty |
dextro- | carvone | FL/FR |
musty |
2- | acetyl pyrrole | FL/FR |
3- | acetyl-2,5-dimethyl furan | FL/FR |
| cocoa butenal | FL/FR |
| hazelnut pyrazine | FL/FR |
| menthofuran | FL/FR |
ketoiso | phorone | FL/FR |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
5- | acetyl-4-methyl thiazole | |
2- | acetyl-5-methyl furan | FL/FR |
roasted | chestnut fragrance | FR |
3,5- | cocoa pyrazine | FL/FR |
3,6- | cocoa pyrazine | FL/FR |
4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
2,4- | dimethyl-5-ethyl thiazole | |
2- | ethyl pyrazine | FL/FR |
| filbert heptenone | FL/FR |
| filbert heptenone B | FL/FR |
| filbert pyrazine | FL/FR |
2,6- | lutidine | FL/FR |
| methoxymethyl pyrazine | FL/FR |
2- | methyl pyrazine | FL/FR |
5- | methyl quinoxaline | FL/FR |
| nutty quinoxaline | FL/FR |
| sesame absolute | FL/FR |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
2,4,5- | trimethyl oxazole | FL/FR |
2,3,5- | trimethyl pyrazine | FL/FR |
| vinyl sulfurol | FL/FR |
oily |
| glyceryl tripropanoate | |
popcorn |
2- | acetyl pyrazine | FL/FR |
roasted |
2- | acetyl-2-pyrroline | |
spicy |
| caraway seed oleoresin | FL/FR |
(-)- | cubenol | FL/FR |
| furfuryl thioacetate | FL/FR |
tropical |
| genet absolute | FL/FR |
| methional | FL/FR |
2- | methyl heptanoic acid | FL/FR |
2,4- | nonadien-1-ol | FL/FR |
woody |
| cyperus root oil (cyperus rotundus) | FR |
(-)- | guaiol | FR |
yeasty |
laevo- | glutamic acid | CS |
|
For Flavor |
|
No flavor group found for these |
6- | acetoxydihydrotheaspirane | FL/FR |
| acetyl acetaldehyde dimethyl acetal | FL |
2- | acetyl-2-pyrroline | |
5- | acetyl-4-methyl thiazole | |
(E)- | aconitic acid | FL |
| benzyl methyl sulfide | FL |
| butyl decanoate | FL/FR |
2(4)-iso | butyl-4(2),6-dimethyl dihydro-4H-1,3,5-dithiazine | FL |
| chocolate pyrazine A | FL/FR |
| chocolate pyrazine B | FL |
| cyclohexyl methyl pyrazine | FL |
2,5- | diethyl thiazole | FL |
6,7- | dihydro-2,3-dimethyl-5H-cyclopentapyrazine | FL |
| dimethyl dihydrocyclopentapyrazine | FL |
6,7- | dimethyl dihydrocyclopentapyrazine | FL |
2,5- | dimethyl pyrazine and 2,6-dimethyl pyrazine mixture | FL |
2,5- | dimethyl thiazole | FL |
2,4- | dimethyl-5-ethyl thiazole | |
| ethyl dimethyl pyrazine | FL |
2- | ethyl-3-methoxypyrazine | FL/FR |
2- | formyl pyrrole | FL |
| green pea pyrazine | FL |
| guaiyl acetate | FL/FR |
| magnolia flower oil | FL/FR |
2- | methoxy-3-propyl pyrazine | FL |
| methyl 2-(methyl thio) acetate | FL |
4-( | methyl thio) butanol | FL |
| pyrazines mixture | FL |
| sulfuryl butyrate | FL/FR |
| sulfuryl decanoate | FL/FR |
| sulfuryl hexanoate | FL/FR |
| sulfuryl isobutyrate | FL/FR |
|
5- | acetyl-2,3-dihydro-1,4-thiazine | FL |
2,4- | dimethyl-3-oxazoline | FL |
| sulfuryl formate | FL |
| sulfuryl octanoate | FL/FR |
| sulfuryl propionate | FL/FR |
1-(2- | thienyl) butanone | FL |
alliaceous |
3- | mercapto-2-pentanone | FL |
2- | methyl thioacetaldehyde | FL |
apple |
(E,Z)-2,6- | nonadien-1-ol | FL/FR |
bitter |
| paullinia cupana seed extract | FL |
bready |
2- | propionyl thiazole | FL |
brown |
| furfural | FL/FR |
burnt |
| furfuryl alcohol | FL |
iso | propenyl pyrazine | FL/FR |
| rum ether | FL/FR |
2,4,5- | trimethyl oxazole | FL/FR |
caramellic |
| fenugreek absolute | FL/FR |
| maltol | FL/FR |
| shoyu furanone | FL/FR |
| toffee furanone | FL/FR |
chemical |
2,5- | dimethyl furan | FL |
citrus |
ketoiso | phorone | FL/FR |
cocoa |
| butyraldehyde | FL |
| cocoa hexenal | FL/FR |
| theobroma cacao extract | FL/FR |
coffee |
| diisoamyl thiomalate | FL |
2,4- | dimethyl thiazole | FL |
corn chip |
2- | acetyl-2-thiazoline | FL |
fatty |
2,4- | decadienal | FL |
| diacetyl trimer | FL |
2- | heptyl furan | FL/FR |
| methyl decanoate | FL/FR |
(E)-7- | methyl-3-octen-2-one | FL/FR |
2,4- | nonadien-1-ol | FL/FR |
2,4- | octadien-1-ol | FL |
(E)-2- | octen-1-ol | FL/FR |
2- | octen-1-ol | FL/FR |
(Z)- | oleic acid | FL/FR |
10- | undecenal (aldehyde C-11 undecylenic) | FL/FR |
fishy |
4,5- | dimethyl thiazole | FL |
floral |
alpha-iso | methyl ionone (90% min.) | FL/FR |
| tetrahydrolinalool | FL/FR |
2- | ethyl-2,5-dihydro-4-methyl thiazole | FL |
fusel |
iso | amyl alcohol | FL/FR |
green |
| cocoa butenal | FL/FR |
| dihydroxyacetophenone (mixed isomers) | FL |
| geranyl formate | FL/FR |
| heptyl butyrate | FL/FR |
| methyl 2-undecynoate | FL |
(E,Z)-2,6- | nonadien-1-yl acetate | FL/FR |
| propylene glycol acetone ketal | FL |
hay |
| genet absolute | FL/FR |
herbal |
| clary sage absolute | FL/FR |
| clary sage oil france | FL/FR |
honey |
| phenethyl isobutyrate | FL/FR |
jammy |
| ethyl cyclopentenolone | FL/FR |
licorice |
sweet | basil oleoresin | FL/FR |
meaty |
3- | mercapto-2-butanone | FL |
2- | methyl 3-(methyl thio) furan | FL |
2- | methyl-3-tetrahydrofuran thiol | FL |
2- | pyridinyl methane thiol | FL |
| sulfurol | FL/FR |
| sulfuryl acetate | FL/FR |
metallic |
2,5- | dihydroxy-1,4-dithiane | FL |
milky |
dextro,laevo-3-( | methyl thio) butanone | FL |
minty |
dextro- | carvone | FL/FR |
musty |
2- | ethoxythiazole | FL |
| hazelnut pyrazine | FL/FR |
| menthofuran | FL/FR |
| propionaldehyde | FL |
2,3,5- | trimethyl pyrazine | FL/FR |
nutty |
2- | acetyl pyrrole | FL/FR |
3- | acetyl-2,5-dimethyl furan | FL/FR |
3- | acetyl-2,5-dimethyl thiophene | FL |
2- | acetyl-3-ethyl pyrazine | FL/FR |
2- | acetyl-3-methyl pyrazine | FL/FR |
2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
2- | acetyl-5-methyl furan | FL/FR |
| arachis hypogaea fruit extract | FL |
3,5- | cocoa pyrazine | FL/FR |
3,6- | cocoa pyrazine | FL/FR |
| coffee furanone | FL/FR |
4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
2- | ethyl pyrazine | FL/FR |
1- | ethyl-2-acetyl pyrrole | FL |
2- | ethyl-6-methyl pyrazine | FL |
| filbert heptenone | FL/FR |
| filbert heptenone B | FL/FR |
| filbert pyrazine | FL/FR |
2,6- | lutidine | FL/FR |
| methoxymethyl pyrazine | FL/FR |
2- | methyl pyrazine | FL/FR |
5- | methyl quinoxaline | FL/FR |
| nutty pyrazine | FL/FR |
| nutty quinoxaline | FL/FR |
| nutty thiazole | FL |
| peanut oxazole | FL |
| sesame absolute | FL/FR |
2,3,5,6- | tetramethyl pyrazine | FL/FR |
2,4,5- | trimethyl thiazole | FL/FR |
| vinyl sulfurol | FL/FR |
oily |
| glyceryl tripropanoate | |
phenolic |
| guaiacyl phenyl acetate | FL/FR |
popcorn |
2- | propionyl-2-thiazoline | FL |
roasted |
2- | acetyl pyrazine | FL/FR |
3,5- | diisobutyl-1,2,4-trithiolane | FL |
| furfuryl thioacetate | FL/FR |
solvent |
1- | heptanol | FL/FR |
spicy |
| caraway seed oleoresin | FL/FR |
(-)- | cubenol | FL/FR |
sulfurous |
| methyl 2-methyl-3-furyl disulfide | FL |
3- | methyl-2-butane thiol | FL |
| potato butanone | FL |
tomato |
| methional | FL/FR |
vegetable |
| potato butyraldehyde | FL |
waxy |
| furfuryl octanoate | FL |
2- | methyl heptanoic acid | FL/FR |
winey |
5- | ethyl-2-methyl pyridine | FL |
|
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
2,5- | dimethyl paradiazine | 2,5- | dimethyl piazine | 2,5- | dimethyl pyrazine natural | 2,5- | dimethyl pyrazine, natural | 2,5- | dimethyl-1,4-diazine | 2,5- | dimethyl-pyrazine | 2,5- | dimethylparadiazine | 2,5- | dimethylpiazine | 2, 5 | dimethylpyrazine | 2,5- | dimethylpyrazine | 2,5- | dimethylpyrazine >80.0%(gc) (contains 2,6-isomer) | | ketine | | pyrazine, 2,5- dimethyl | | pyrazine, 2,5-dimethyl- |
Articles:
PubMed: | Relationship of sensory and instrumental aroma measurements of dark chocolate as influenced by fermentation method, roasting and conching conditions. |
J-Stage: | Chemical Profiles of Methylpyrazines Contained in Commercially Available Natto |
PubMed: | HS-SPME GC/MS characterization of volatiles in raw and dry-roasted almonds (Prunus dulcis). |
J-Stage: | Effect of 2,5-Dimethylpyrazine on Uterine Contraction in Late Stage of Pregnant Female Rats |
PubMed: | Chemical communication during foraging in the harvesting ants Messor pergandei and Messor andrei. |
J-Stage: | Effect of Alkylpyrazine Derivatives on the Duration of Pentobarbital-Induced Sleep, Picrotoxicin-Induced Convulsion and ?-Aminobutyric Acid (GABA) Levels in the Mouse Brain |
PubMed: | Headspace-solid phase microextraction-gas chromatography-tandem mass spectrometry (HS-SPME-GC-MS2) method for the determination of pyrazines in perilla seed oils: impact of roasting on the pyrazines in perilla seed oils. |
PubMed: | Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones. |
PubMed: | Determination of the alkylpyrazine composition of coffee using stable isotope dilution-gas chromatography-mass spectrometry (SIDA-GC-MS). |
PubMed: | Comparison of direct mass spectrometry methods for the on-line analysis of volatile compounds in foods. |
PubMed: | Volatile profiling of high quality hazelnuts (Corylus avellana L.): chemical indices of roasting. |
PubMed: | Characterization of cocoa liquors by GC-MS and LC-MS/MS: focus on alkylpyrazines and flavanols. |
PubMed: | [Balance hypothesis of action of socially significant volatile chemosignals on reactivity of chromosome machinery of the bone marrow dividing cells in the house mouse Mus domesticus L]. |
PubMed: | [Action of two pyrazine-containing chemosignals on cells of bone marrow and testes in male house mouse Mus musculus L]. |
PubMed: | Volatile compounds of black cumin seeds (Nigella sativa L.) from microwave-heating and conventional roasting. |
PubMed: | Identification of tartary buckwheat tea aroma compounds with gas chromatography-mass spectrometry. |
PubMed: | GC-MS based metabolomics for rapid simultaneous detection of Escherichia coli O157:H7, Salmonella Typhimurium, Salmonella Muenchen, and Salmonella Hartford in ground beef and chicken. |
PubMed: | [The role of metabolic activation of promutagens in the genome destabilization under pheromonal stress in the house mouse (Mus musculus)]. |
PubMed: | Effects of roasting conditions on the physicochemical properties and volatile distribution in perilla oils (Perilla frutescens var. japonica). |
PubMed: | Identification of 2-ethyl-4-methyl-3-thiazoline and 2-isopropyl-4-methyl-3-thiazoline for the first time in nature by the comprehensive analysis of sesame seed oil. |
PubMed: | Grueneberg ganglion neurons are activated by a defined set of odorants. |
PubMed: | Volatile composition and sensory analysis of Italian gianduja torrone. |
PubMed: | High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones. |
PubMed: | catena-Poly[[[diaqua-bis(8-hydroxy-quinoline N-oxide-κO)cobalt(II)]-μ-2,5-dimethyl-pyrazine 1,4-dioxide-κO:O] bis-(perchlorate)]. |
PubMed: | [Effects of "pheromone-like" pyrazine-containing substances on stability of genetic apparatus in bone marrow cells of the male house mouse (Mus musculus L.)]. |
PubMed: | Coffee aroma--statistical analysis of compositional data. |
PubMed: | Syntheses, structures, and photoluminescence of a series of silver(I) sulfonates with pyrazine derivatives. |
PubMed: | Alkyldimethylpyrazines in the defensive spray of Phyllium westwoodii: a first for order Phasmatodea. |
PubMed: | Identification of chemicals emitted by calling males of the Sapote fruit fly, Anastrepha serpentina. |
PubMed: | Strong through-space two-halide magnetic exchange of -234 K in (2,5-dimethylpyrazine)copper(II) bromide. |
PubMed: | A binuclear Cu(II) metallacycle capable of discerning between pyrazine and its different methyl-substituted derivatives based on reversible intracage metal-ligand binding. |
PubMed: | 2,5-Dimethyl-pyrazine 1,4-dioxide. |
PubMed: | Formation of pyrazines and a novel pyrrole in Maillard model systems of 1,3-dihydroxyacetone and 2-oxopropanal. |
PubMed: | [Effect of the estrous cycle stage on sensitivity to pheromone 2,5-dimethylpyrazine in the house mouse Mus musculus]. |
PubMed: | Competition between photochemistry and energy transfer in UV-excited diazabenzenes. 4. UV photodissociation of 2,3-, 2,5-, and 2,6-dimethylpyrazine. |
PubMed: | [Chromosomal abnormalities and spleenocyte production in laboratory mouse males after exposure to stress chemosignals]. |
PubMed: | Structural study of silver(I) sulfonate complexes with pyrazine derivatives. |
PubMed: | Mice respond differently to urine and its major volatile constituents from male and female ferrets. |
PubMed: | Solitary foraging in the ancestral South American ant, Pogonomyrmex vermiculatus. Is it due to constraints in the production or perception of trail pheromones? |
PubMed: | Construction of polyoxometalates-based coordination polymers through direct incorporation between polyoxometalates and the voids in a 2D network. |
PubMed: | Degradation of 2,5-dimethylpyrazine by Rhodococcus erythropolis strain DP-45 isolated from a waste gas treatment plant of a fishmeal processing company. |
PubMed: | Magnetic study on a two-dimensional coordination polymer with mixed bridging ligands. |
PubMed: | Attenuation of the production of inositol 1,4,5-trisphosphate in the mouse vomeronasal organ by antibodies against the alphaq/11 subfamily of G-proteins. |
PubMed: | Synthesis, a case of isostructural packing, and antimicrobial activity of silver(I)quinoxaline nitrate, silver(I)(2,5-dimethylpyrazine) nitrate and two related silver aminopyridine compounds. |
PubMed: | [Induction of meiotic disturbances in spermatocytes I by pheromones as an inhibiting mechanism of male reproductive function in house mice]. |
PubMed: | Influence of steric hindrance of organic ligand on the structure of Keggin-based coordination polymer. |
PubMed: | Role of the solvent glycerol in the Maillard reaction of d-fructose and l-alanine. |
PubMed: | Tuning the electronic communication and rates of intramolecular electron transfer of dimers of trinuclear ruthenium clusters: bridging and ancillary ligand effects. |
PubMed: | Putative chemosignals of the ferret (Mustela furo) associated with individual and gender recognition. |
PubMed: | Determination of the 2H/1H and 15N/14N ratios of Alkylpyrazines from coffee beans (Coffea arabica L. and Coffea canephoravar. robusta) by isotope ratio mass spectrometry. |
PubMed: | Effects of water content on volatile generation and peptide degradation in the maillard reaction of glycine, diglycine, and triglycine. |
PubMed: | Reactivity of epicatechin in aqueous glycine and glucose maillard reaction models: quenching of C2, C3, and C4 sugar fragments. |
PubMed: | Identification of major histocompatibility complex-regulated body odorants by statistical analysis of a comparative gas chromatography/mass spectrometry experiment. |
PubMed: | Synthesis, crystal structures, and magnetism of cobalt coordination polymers based on dicyanamide and pyrazine-dioxide derivatives. |
PubMed: | Sex-specific responses to urinary chemicals by the mouse vomeronasal organ. |
PubMed: | Aroma compounds in sweet whey powder. |
PubMed: | Volatiles production and attractiveness to the Mexican fruit fly of Enterobacter agglomerans isolated from apple maggot and Mexican fruit flies. |
PubMed: | Primer effects by conspecific odors in house mice: a new perspective in the study of primer effects on reproductive activities. |
PubMed: | Pyrazine derivatives in cigarette smoke inhibit hamster oviductal functioning. |
PubMed: | Odors detected by mice deficient in cyclic nucleotide-gated channel subunit A2 stimulate the main olfactory system. |
PubMed: | [Chemical profiles of methylpyrazines contained in commercially available natto]. |
PubMed: | [Induction of dominant lethals in progeny of male CBA mice after pheromonal action]. |
PubMed: | Effect of 2,5-dimethylpyrazine on uterine contraction in late stage of pregnant female rats. |
PubMed: | [The female pheromone 2,5-dimethylpyrazine induces sperm head abnormalities in male CBA mice]. |
PubMed: | Purine metabolizing capability of Enterobacter agglomerans affects volatiles production and attractiveness to Mexican fruit fly. |
PubMed: | [Olfactory stress and modification of phagocytosis in peripheral blood cells of adult male mice]. |
PubMed: | catena-poly[[(acetonitrile-N)dichlorocopper(II)]-mu-2,5-dimethylpyrazine-kappa2N:N']. |
PubMed: | Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain. |
PubMed: | 1-octen-3-ol isolated from bont ticks attracts Amblyomma variegatum. |
PubMed: | Syntheses, structures, and physicochemical properties of diruthenium compounds of tetrachlorocatecholate with metal-metal bonded Ru(3+)(mu-OR)(2)Ru(3+) and Ru(3.5+)(mu-OR)(2)Ru(3.5+) cores (R = CH(3) and C(2)H(5)). |
PubMed: | Recruitment pheromone in the harvester ant genus Pogonomyrmex. |
PubMed: | [Genotype-specific changes of certain functional indicators of immunocompetent cells in male laboratory mice under conditions of pheromone stress]. |
PubMed: | Volatile flavor components of rice cakes. |
PubMed: | Pyrazine formation from serine and threonine. |
PubMed: | Effects of roasting on pyrazine contents and oxidative stability of red pepper seed oil prior to its extraction. |
PubMed: | Oxidative DNA damage induced by aminoacetone, an amino acid metabolite. |
PubMed: | Role of the adrenal gland and adrenal-mediated chemosignals in suppression of estrus in the house mouse: the lee-boot effect revisited. |
PubMed: | Inhibitory effect of 2,5-dimethylpyrazine on oxytocic agent-induced uterine hypercontraction of normal or pregnant female rats. |
PubMed: | [Physiological and pharmacological activities of simple alkyl- and arylpyrazines]. |
PubMed: | Rational Design of a Novel Intercalation System. Layer-Gap Control of Crystalline Coordination Polymers, {[Cu(CA)(H(2)O)(m)()](G)}(n)() (m = 2, G = 2,5-Dimethylpyrazine and Phenazine; m = 1, G = 1,2,3,4,6,7,8,9-Octahydrophenazine). |
PubMed: | Attractants fromStaphylococcus aureus cultures for Mexican fruit fly,Anastrepha ludens. |
PubMed: | Effects of 2,5-dimethylpyrazine on plasma testosterone and polyamines- and acid phosphatase-levels in the rat prostate. |
PubMed: | Inhibition of sexual maturation in juvenile female and male mice by a chemosignal of female origin. |
PubMed: | Long-term effect of a urinary chemosignal on reproductive fitness in female mice. |
PubMed: | Effects of dimethylpyrazine isomers on reproductive and accessory reproductive organs in male rats. |
PubMed: | Contents of poison apparatus and their relation to trail-following in the antDaceton armigerum. |
PubMed: | Effects of 2,5-dimethylpyrazine on reproductive and accessory reproductive organs in female rats. |
PubMed: | Chemotaxonomic study of undescribed species ofMyrmica ant from Idaho. |
PubMed: | Interactions of heterocyclic Maillard products with the hepatic microsomal monooxygenase system. |
PubMed: | Dynamics of excretion of urinary chemosignals in the house mouse (Mus musculus) during the natural estrous cycle. |
PubMed: | Adrenal-mediated endogenous metabolites inhibit puberty in female mice. |
PubMed: | Synthesis and antimetastatic properties of stereoisomeric tricyclic bis(dioxopiperazines) in the Lewis lung carcinoma model. |
PubMed: | Identification of trail pheromone of the antTetramorium caespitum L. (Hymenoptera: Myrmicinae). |
PubMed: | Identification of 2,5-dimethyl-pyrazine in the volatile flavour compounds of potato chips. |
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