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m-cresol
Notes:
Flavouring ingredient
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Pell Wall Perfumes Hand-made fragrances Pell Wall maintains a broad palette of ingredients & in order to keep stocks fresh & the options wide we also sell from our own stock. Pell Wall was founded by perfumer Chris Bartlett to provide exclusive hand-made fragrances to a select few people who love them. All our products are created using fine quality ingredients, many of which we also offer for sale to other perfumers and enthusiasts. Pell Wall make fragrances for men, for women and for the home. Email: Info Email: Sales Voice: +44 (0) 20 3745 0887 Facebook Twitter Instagram Blog Product(s): m-Cresol, 1% in DPG Arctander has this to say about it: “Dry-tarry, medicinal-leathery odor, conventionally described as “phenolic. Useful as a floralizing companion to Indole in sharp-exotic flower fragrances, Lily (Bermuda-lily, etc.), Narcisse, etc. Concentration in the perfume composition will usually be about 0.1%, sometimes slightly higher, mostly lower than 0.1%.”
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 03-52100 META-CRESOL 03-52105 META-CRESOL USP GRADE
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Sigma-Aldrich Complete Supply Chain The perfect blend of products and services that bring your creativity to life. Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards. Email: Information US Email: Sales US Voice: 800-244-1173 US Fax: 800-368-4661 Facebook Twitter Instagram Linkedin Flavors and Fragrances Analysis FandF Newsletter Subscription Flavors and Fragrances Learning Center Certified Food Grade Products Product(s): W353000 m-Cresol, ≥98%, FG SDS
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TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): C0401 m-Cresol >98.0%(GC)
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The Good Scents Company Fragrance Creators For your fragrance creations. US Email: Sales US Voice: 414-764-2659 Product(s): NOVOLAK 562
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| CAS Number: | 108-39-4 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 203-577-9 | |
| FDA UNII: | GGO4Y809LO | |
| Nikkaji Web: | J1.186J | |
| Beilstein Number: | 0506719 | |
| MDL: | MFCD00002302 | |
| CoE Number: | 617 | |
| XlogP3: | 2.00 (est) | |
| Molecular Weight: | 108.13996000 | |
| Formula: | C7 H8 O | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: food contact resinous and polymeric coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 692 m-cresol |
| DG SANTE Food Flavourings: | 04.026 3-methylphenol |
| DG SANTE Food Contact Materials: | 3-methylphenol |
| FEMA Number: | 3530 m-cresol |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 108-39-4 ; M-CRESOL |
| FDA Regulation: | |
| FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS Subpart C--Substances for Use as Components of Coatings Sec. 175.300 Resinous and polymeric coatings. FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use Sec. 177.2410 Phenolic resins in molded articles. | |
Physical Properties:
| Appearance: | white to amber liquid to crystals (est) |
| Assay: | 98.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.03400 to 1.03700 @ 20.00 °C. |
| Pounds per Gallon - (est).: | 8.614 to 8.639 |
| Refractive Index: | 1.53800 to 1.54200 @ 20.00 °C. |
| Melting Point: | 11.00 to 12.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 202.00 to 203.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 120.00 to 121.00 °C. @ 50.00 mm Hg |
| Vapor Pressure: | 0.110000 mmHg @ 25.00 °C. |
| Vapor Density: | 7.07 ( Air = 1 ) |
| Flash Point: | 187.00 °F. TCC ( 86.11 °C. ) |
| logP (o/w): | 1.960 |
| Soluble in: | |
| alcohol | |
| water, 8890 mg/L @ 25 °C (est) | |
| water, 2.27E+04 mg/L @ 25 °C (exp) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor Type: phenolic | |
| Odor Strength: | high , recommend smelling in a 0.01 % solution or less |
| Substantivity: | 43 hour(s) at 100.00 % |
| medicinal woody leathery phenolic | |
| Odor Description: at 0.01 % in dipropylene glycol. | medicinal woody leather phenolic Luebke, William tgsc, (1995) |
| Odor and/or flavor descriptions from others (if found). | |
| Sigma-Aldrich | |
| m-Cresol, ≥98%, FG | |
| Odor Description: | medicinal; woody; ethereal |
| Pell Wall Perfumes | |
| m-Cresol, 1% in DPG | |
| Odor Description: | Medicinal, woody, leather, phenolic Arctander has this to say about it: “Dry-tarry, medicinal-leathery odor, conventionally described as “phenolic. Useful as a floralizing companion to Indole in sharp-exotic flower fragrances, Lily (Bermuda-lily, etc.), Narcisse, etc. Concentration in the perfume composition will usually be about 0.1%, sometimes slightly higher, mostly lower than 0.1%.” |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
antimicrobial agents perfuming agents |
Suppliers:
| EMD Millipore |
| For experimental / research use only. |
| m-Cresol |
| Pell Wall Perfumes |
| m-Cresol, 1% in DPG
Odor: Medicinal, woody, leather, phenolic Use: Arctander has this to say about it: “Dry-tarry, medicinal-leathery odor, conventionally described as “phenolic. Useful as a floralizing companion to Indole in sharp-exotic flower fragrances, Lily (Bermuda-lily, etc.), Narcisse, etc. Concentration in the perfume composition will usually be about 0.1%, sometimes slightly higher, mostly lower than 0.1%.” |
| Penta International |
| META-CRESOL USP GRADE |
| Penta International |
| META-CRESOL |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| m-Cresol |
| Sigma-Aldrich |
| m-Cresol, ≥98%, FG
Odor: medicinal; woody; ethereal |
| Certified Food Grade Products |
| TCI AMERICA |
| For experimental / research use only. |
| m-Cresol >98.0%(GC) |
| The Good Scents Company |
| NOVOLAK 562 |
Safety Information:
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| T - Toxic. | |
|
R 24/25 - Toxic in contact with skin and if swallowed. R 34 - Causes burns. S 02 - Keep out of the reach of children. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. S 45 - In case of accident or if you feel unwell seek medical advice immediately. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-rat LD50 [sex: M] 242 mg/kg (E.I. du Pont de Nemours & Company, 1969a) oral-mouse LD50 828 mg/kg (E.I. du Pont de Nemours & Company, 1969a) intraperitoneal-mouse LD50 168 mg/kg (E.I. du Pont de Nemours & Company, 1969a) gavage-rat LD50 [sex: M] 520 mg/kg (Carpenter, 1949b) oral-rat LD50 242 mg/kg GASTROINTESTINAL: PERITONITIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 3-5/1969 oral-rabbit LDLo 1400 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944. intravenous-rabbit LDLo 280 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944. oral-mouse LD50 828 mg/kg Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974. intraperitoneal-mouse LD50 168 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 56, 1959. intraperitoneal-guinea pig LDLo 100 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935. | |
| Dermal Toxicity: | |
|
subcutaneous-rat LDLo 900 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 56, 1959. skin-rat LD50 1100 mg/kg Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974. subcutaneous-rabbit LDLo 500 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935. subcutaneous-mouse LDLo 450 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935. subcutaneous-guinea pig LDLo 300 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 56, 1959. subcutaneous-cat LDLo 180 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944. | |
| Inhalation Toxicity: | |
|
inhalation-rat LC50 > 710 mg/m3/1H Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944. | |
Safety in Use Information:
| Category: | food contact resinous and polymeric coatings | ||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for meta-cresol usage levels up to: | |||
| 0.0100 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.12 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.10 (μg/capita/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 11. Update in publication number(s): 29 | |||
| Click here to view publication 11 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 0.50000 | 1.00000 | |
| beverages(nonalcoholic): | - | - | |
| beverages(alcoholic): | 0.30000 | 1.00000 | |
| breakfast cereal: | 0.50000 | 5.00000 | |
| cheese: | 0.10000 | 0.50000 | |
| chewing gum: | 0.10000 | 0.50000 | |
| condiments / relishes: | 0.10000 | 0.50000 | |
| confectionery froastings: | 0.10000 | 0.50000 | |
| egg products: | 0.10000 | 0.50000 | |
| fats / oils: | 0.10000 | 0.50000 | |
| fish products: | 0.50000 | 5.00000 | |
| frozen dairy: | 0.10000 | 0.50000 | |
| fruit ices: | 0.10000 | 0.50000 | |
| gelatins / puddings: | 0.10000 | 0.50000 | |
| granulated sugar: | 0.10000 | 0.50000 | |
| gravies: | 0.30000 | 0.50000 | |
| hard candy: | 0.10000 | 0.50000 | |
| imitation dairy: | 0.10000 | 0.50000 | |
| instant coffee / tea: | 0.30000 | 0.50000 | |
| jams / jellies: | 0.10000 | 0.50000 | |
| meat products: | 0.30000 | 1.00000 | |
| milk products: | 0.10000 | 0.50000 | |
| nut products: | 0.30000 | 0.50000 | |
| other grains: | 0.50000 | 5.00000 | |
| poultry: | 0.50000 | 5.00000 | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | 1.00000 | 10.00000 | |
| snack foods: | 0.30000 | 0.50000 | |
| soft candy: | - | - | |
| soups: | 0.30000 | 0.50000 | |
| sugar substitutes: | 0.10000 | 0.50000 | |
| sweet sauces: | 0.10000 | 0.50000 | |
Safety References:
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf | |
| Flavouring Group Evaluation 58 (FGE.58) Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf | |
| Flavouring Group Evaluation 60 (FGE.60): Consideration of eugenol and related hydroxyallylbenzene derivatives evaluated by JECFA (65th meeting) structurally related to ring- substituted phenolic substances evaluated by EFSA in FGE.22 (2006) View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25 View page or View pdf | |
| Scientific Opinion on the safety and efficacy of phenol derivatives containing ring-alkyl, ring-alkoxy and side-chains with an oxygenated functional group (chemical group 25) when used as flavourings for all species View page or View pdf | |
| EPI System: | View |
| EPA-Iris: | IRIS |
| NIOSH International Chemical Safety Cards: | search |
| NIOSH Pocket Guide: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 108-39-4 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 342 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WISER: | UN 2076 |
| WGK Germany: | 1 |
| 3-methylphenol | |
| Chemidplus: | 0000108394 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 108-39-4 |
References:
| 3-methylphenol | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 108-39-4 |
| Pubchem (cid): | 342 |
| Pubchem (sid): | 134970512 |
| Flavornet: | 108-39-4 |
| Pherobase: | View |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Metabolomics Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C01467 |
| HMDB (The Human Metabolome Database): | HMDB02048 |
| FooDB: | FDB008788 |
| YMDB (Yeast Metabolome Database): | YMDB01730 |
| Export Tariff Code: | 2907.12.0000 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| Wikipedia: | View |
| Wikipedia2: | View2 |
| Formulations/Preparations: •grade: technical (95-98%) •pure cresol is a mixture of ortho-, meta- & para-isomers. crude cresol (commercial cresol) is a mixture of aromatic cmpd containing about 20% of o-cresol, 40% of m-cresol, & 30% of p-cresol with small amt of phenol & xylenols. •franklin cresolis, 50% m-cresol, 31% soap cancelled •saponated cresol solution n.f., 50% m-cresol, 35% soap cancelled •bacticin, 0.4660% m-cresol, 0.4630% 2,4-xylenol cancelled •celcure dry mix (chemicals for wood preserving), 5% m-cresol, 50% copper sulfate pentahydrate, 45% potassium dichromate cancelled •rover's dog shampoo, 0.4% m-cresol, 1.0% paradichlorobenzene, 0.1% pine oil, 19.3% soap cancelled •gallex, 0.4660% m-cresol, 0.4630% 2,4-xylenol active •generally m- and p- isomers are used industrially as a mixture containing 40% to 65% m-cresol. | |
Potential Blenders and core components note
| For Odor | ||
| animal | ||
| 2-iso | butyl quinoline | FR |
| floral | ||
| cananga oil | FL/FR | |
| floral methanol | FR | |
| herbal | ||
| ajowan seed oil | FL/FR | |
| cananga fruit oil | FR | |
| 2,10- | epoxypinane | FR |
| matricaria chamomilla flower oil | FL/FR | |
| white | thyme oil | FL/FR |
| thyme oil (thymus zygis gracillis) spain | FL/FR | |
| red | thyme oil spain | FL/FR |
| thymol | FL/FR | |
| leathery | ||
| 2-tert- | butyl-6-methyl phenol | FR |
| medicinal | ||
| 2,6- | xylenol | FL/FR |
| orris | ||
| 2(1)- | orris butanal | FL/FR |
| phenolic | ||
| ortho- | cresol | FR |
| 2- | propyl phenol | FL/FR |
| 4- | vinyl phenol | FL/FR |
| resinous | ||
| amber oil CO2 extract | FR | |
| smoky | ||
| birch tar oil | FL/FR | |
| spicy | ||
| 4- | methyl guaiacol | FL/FR |
| For Flavor | ||
| No flavor group found for these | ||
| birch tar oil | FL/FR | |
| 2(1)- | orris butanal | FL/FR |
| 2- | propyl phenol | FL/FR |
| burnt | ||
| 2,6- | xylenol | FL/FR |
| floral | ||
| cananga oil | FL/FR | |
| herbal | ||
| ajowan seed oil | FL/FR | |
| matricaria chamomilla flower oil | FL/FR | |
| white | thyme oil | FL/FR |
| thyme oil (thymus zygis gracillis) spain | FL/FR | |
| red | thyme oil spain | FL/FR |
| phenolic | ||
| thymol | FL/FR | |
| 4- | vinyl phenol | FL/FR |
| spicy | ||
| 4- | methyl guaiacol | FL/FR |
Potential Uses:
| antimicrobial agents | ||
| castoreum | FR | |
| myrrh | FR |
Occurrence (nature, food, other): note
| asparagus shoot Search Trop Picture | |
| coal tar Search PMC Picture | |
| coffee arabica coffee bean Search Trop Picture | |
| jasmin absolute china @ 2.33% Data GC Search Trop Picture | |
| myrrh oil Search Trop Picture | |
| osmanthus absolute @ trace% Data GC Search Trop Picture | |
| prangos uechtritzii boiss. et hausskn. fruit oil turkey @ 1.40% Data GC Search Trop Picture | |
| sauromatum guttatum Search Trop Picture | |
| tea leaf Search Trop Picture |
Synonyms:
| 3- | cresol |
| m- | cresol |
| m- | cresol food grade |
| cresol meta pure | |
| meta- | cresol N- grade |
| m- | cresylic acid |
| meta- | cresylic acid |
| 1- | hydroxy-3-methyl benzene |
| 1- | hydroxy-3-methylbenzene |
| 3- | hydroxytoluene |
| 3- | methyl phenol |
| meta- | methyl phenol |
| 3- | methyl-1-hydroxybenzene |
| 1- | methyl-3-hydroxybenzene |
| 3- | methylphenol |
| m- | methylphenol |