butyl amine
butylamine
 
Notes:
Found in mulberry leaves, kale, swede, tomato, wheat bread, cheeses, caviar, raw fatty fish, cooked chicken or beef, beer, cocoa, and other foodstuffs. Flavouring agent
  • Augustus Oils
    • Augustus Oils Ltd
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      A wealth of experience, expertise and knowledge has allowed Augustus to bridge the gulf in expectation and trust between growers and users of natural ingredients. The Company works in partnership with customers on the one hand, and growers, farmers and distillers on the other. Both users and producers can then focus on exactly what they do best, while skilled Augustus technicians closely monitor and control the delivered product. This ensures users can have the confidence that they will receive the best raw materials suited to their requirements.
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      N Butyl Amine
       
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    • Penta International Corporation
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      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
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      Product(s):
      02-51200 BUTYLAMINE
       
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  • Synerzine
    • Synerzine, Inc.
      Innovation. Customization. Aroma Ingredients.
      Synerzine is a leading supplier of flavor and fragrance ingredients.
      Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust.
      Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster.
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      Product(s):
      W3130 Butylamine
       
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    • TCI AMERICA
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      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
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      Product(s):
      B0707 Butylamine >99.0%(GC)
       
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CAS Number: 109-73-9Picture of molecule3D/inchi
Other(deleted CASRN): 42939-72-0
ECHA EINECS - REACH Pre-Reg: 203-699-2
FDA UNII: N2QV60B4WR
Nikkaji Web: J2.436H
Beilstein Number: 0605269
MDL: MFCD00011690
CoE Number: 524
XlogP3: 1.00 (est)
Molecular Weight: 73.13867000
Formula: C4 H11 N
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 1582  butylamine
DG SANTE Food Flavourings: 11.003  butylamine
FEMA Number: 3130 butylamine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):109-73-9 ; BUTYLAMINE
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Physical Properties:
Appearance: colorless to yellow clear liquid (est)
Assay: 99.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 0.73200 to 0.74000 @  25.00 °C.
Pounds per Gallon - (est).: 6.091 to  6.158
Refractive Index: 1.39800 to 1.40400 @  20.00 °C.
Melting Point: -49.00 °C. @ 760.00 mm Hg
Boiling Point: 77.00 to  78.00 °C. @ 760.00 mm Hg
Vapor Pressure: 92.900000 mmHg @ 25.00 °C.
Vapor Density: 2.5 ( Air = 1 )
Flash Point: 30.00 °F. TCC ( -1.11 °C. )
logP (o/w): 0.930
Soluble in:
 alcohol
 ether
 water, 1.00E+06 mg/L @ 20 °C (exp)
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Organoleptic Properties:
 
Odor Type: ammoniacal
 
 ammoniacal  fishy  
Odor Description:
at 0.10 % in propylene glycol. 
ammonia-like fishy
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Augustus Oils
N Butyl Amine
Services
BASF
Butylamine
Eastman Chemical
Mono-N-Butylamine
EMD Millipore
For experimental / research use only.
Butylamine
Penta International
BUTYLAMINE
Santa Cruz Biotechnology
For experimental / research use only.
1-Butylamine
Sigma-Aldrich
Butylamine, ≥99%
Odor: meaty; fishy
Certified Food Grade Products
Synerzine
Butylamine
Taminco (Eastman)
mono-n-butylamine
TCI AMERICA
For experimental / research use only.
Butylamine >99.0%(GC)
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
C - Corrosive.
R 11 - Highly flammable.
R 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R 35 - Causes severe burns.
S 02 - Keep out of the reach of children.
S 03 - Keep in cool place.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 29 - Do not empty into drains.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  366 mg/kg
BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 63, Pg. 150, 1982.

oral-mouse LD50  430 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 40(11), Pg. 21, 1975.

intravenous-mouse LD50  198 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 82, 1946.

intraperitoneal-mouse LD50  629 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 82, 1946.

oral-guinea pig LD50  430 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 40(11), Pg. 21, 1975.

Dermal Toxicity:
skin-rabbit LD50 850 ul/kg
Union Carbide Data Sheet. Vol. 7/19/1965

skin-guinea pig LD50 500 ul/kg
Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944.

Inhalation Toxicity:
inhalation-mouse LC50 800 mg/m3/2H
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 28, 1982.

inhalation-rat TCLo 4000 ppm/4H
Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 343, 1949.

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Safety in Use Information:
Category: flavoring agents
Recommendation for butyl amine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 89.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.01 (μg/capita/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
Click here to view publication 4
 average usual ppmaverage maximum ppm
baked goods: -0.10000
beverages(nonalcoholic): --
beverages(alcoholic): -0.10000
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.10000
fruit ices: -0.10000
gelatins / puddings: -0.10000
granulated sugar: --
gravies: --
hard candy: -0.10000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 86, (FGE.86)[1] - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting)
View page or View pdf
EPI System: View
NIOSH International Chemical Safety Cards: search
NIOSH Pocket Guide: search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 109-73-9
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 8007
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 1125
WGK Germany: 1
 butan-1-amine
Chemidplus: 0000109739
EPA/NOAA CAMEO: hazardous materials
RTECS: 109-73-9
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References:
 butan-1-amine
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 109-73-9
Pubchem (cid): 8007
Pubchem (sid): 134973851
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEBI: View
CHEMBL: View
HMDB (The Human Metabolome Database): HMDB31321
FooDB: FDB003380
Export Tariff Code: 2921.19.1000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
For Odor
fishy
fishy
1-amino-2-propanolCS
 pyridine 
 triethyl amine 
sulfurous
 fish thiolFL/FR
 
For Flavor
 
No flavor group found for these
2-acetyl-1-pyrrolineFL
 amyl amineFL
(±)-sec-butyl amineFL
isobutyl amineFL
 ethyl amineFL
 hexyl amineFL
2-methyl butyl amineFL
isopentylidene isopentyl amineFL
 phenethyl amineFL
 propionyl pyrroline 1% in vegatable oil triglycerideFL
isopropyl amineFL
 pyridine 
 triethyl amine 
(R)-N,N,alpha-trimethyl benzyl amineFL
 tripropyl amineFL
ammoniacal
2-methyl piperidineFL
fishy
4,5-dimethyl thiazoleFL
3-penten-2-oneFL
 trimethyl amineFL
sulfurous
 fish thiolFL/FR
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 mulberry leaf
Search Trop  Picture
 soybean seed
Search Trop  Picture
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Synonyms:
1-aminobutane
 butan-1-amine
 butanamine
1-butanamine
mono-butyl amine
N-butyl amine
 butyl-amine
 butylamine
1-butylamine
norvalamine
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Articles:
Info: aliphatic and aromatic amines and amides
PubMed: Quantification of isocyanates and amines in polyurethane foams and coated products by liquid chromatography-tandem mass spectrometry.
PubMed: Gas chromatography-mass spectrometry assessment of amines in Port wine and grape juice after fast chloroformate extraction/derivatization.
PubMed: Determination of volatile nitrosamines in various meat products using comprehensive gas chromatography-nitrogen chemiluminescence detection.
PubMed: Development and application of a method for analysis of phthalates in ham sausages by solid-phase extraction and gas chromatography-mass spectrometry.
PubMed: A new ultra-pressure liquid chromatography method for the determination of biogenic amines in cheese.
PubMed: Determination of aliphatic amines by cation-exchange chromatography with suppressed conductivity detection after solid phase extraction.
PubMed: Synthesis of N-4-butylamine acridone and its use as fluorescent probe for ctDNA.
PubMed: Olfactory responses in a gustatory organ of the malaria vector mosquito Anopheles gambiae.
PubMed: Dermal, inhalation, and internal exposure to 1,6-HDI and its oligomers in car body repair shop workers and industrial spray painters.
PubMed: Protection of originality of Tokaji AszĂș: amines and organic acids in botrytized wines by high-performance liquid chromatography.
PubMed: Synthesis of haptens and development of an immunoassay for the olive fruit fly pheromone.
PubMed: Developmental toxicity of oral n-butylamine hydrochloride and inhaled n-butylamine in rats.
PubMed: Maillard reaction of D-glucose: identification of a colored product with conjugated pyrrole and furanone rings.
PubMed: Structure of green pigment formed by the reaction of caffeic acid esters (or chlorogenic acid) with a primary amino compound.
PubMed: Reduction of tetrazolium salt XTT by aminoreductone formed during the Maillard reaction of lactose.
PubMed: Effect of common food preservatives on mycelial growth and spore germination of Fusarium oxysporum.
PubMed: Rapid semi-quantitative estimation of N-nitrosodibutylamine and N-nitrosodibenzylamine in smoked hams by solid-phase microextraction followed by gas chromatography-thermal energy analysis.
PubMed: Quantitative determination of amines in wine by liquid chromatography.
PubMed: Investigations on organ-specific metabolism and genotoxic effects of the urinary bladder carcinogen N-nitrosobutyl-3-carboxypropylamine (BCPN) and its analogs N-nitrosodibutylamine (NDBA) and N-nitrosobutyl-4-hydroxybutylamine (4-OH-NDBA).
PubMed: Trapping of reactive intermediates from the nitrosation of primary amines by a new type of scavenger reagent.
PubMed: Evaluation of organosolv processes for the fractionation and modification of corn stover for bioconversion.
PubMed: Effect of butylated hydroxyanisole on in vitro and in vivo nitrosation of dibutylamine.
PubMed: Possible underestimation of nitrosatable amine levels in artificial saliva extracts of children's rubber pacifiers and baby-bottle teats.
PubMed: Correlations between skin sensitization potential and chemical reactivity for p-nitrobenzyl compounds.
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