Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Organoleptic Properties:
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Odor Type: sulfurous |
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| sulfurous garlic onion egg nog coffee |
Odor Description: at 0.10 % in propylene glycol. | sulfury garlic onion egg coffee |
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| sulfurous fatty beefy roasted beefy onion cooked onion egg nog coffee garlic |
Odor Description:
| Sulfureous, fatty, stewed beef, sauteed onion, egg, coffee and garlic Mosciano, Gerard P&F 23, No. 1, 33, (1998) |
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Flavor Type: sulfurous |
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| sulfurous vegetable savory meaty garlic onion |
Taste Description: at 1.00 ppm. | Sulfureous, vegetative, savory meaty, garlic and onion Mosciano, Gerard P&F 23, No. 1, 33, (1998) |
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Odor and/or flavor descriptions from others (if found). |
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Sigma-Aldrich |
1-Butanethiol, ≥98% |
Odor Description: | alliaceous (onion, garlic) |
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Cosmetic Information:
Suppliers:
Advanced Biotech |
BUTYL MERCAPTAN SYNTHETIC
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Beijing Lys Chemicals |
1-Butanethiol
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Chevron Phillips |
n-Butyl Mercaptan
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DeLong Chemicals America |
1-Butanethiol, Kosher
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EMD Millipore |
For experimental / research use only. |
1-Butanethiol
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Jinan Enlighten Chemical Technology(Wutong Aroma ) |
n-Butyl mercaptan, Kosherk
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Natural Advantage |
Butanethiol, 1- Nat
Flavor: alliaceous, dairy, meaty, poultry, sulphurous |
Riverside Aromatics LTD.is the exclusive distributor for Europe in UK for any non-US based inquiries |
Penta International |
1-BUTANETHIOL NATURAL
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Penta International |
1-BUTANETHIOL
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Riverside Aromatics |
1-BUTANETHIOL, NATURAL
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Santa Cruz Biotechnology |
For experimental / research use only. |
1-Butanethiol
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Sigma-Aldrich |
1-Butanethiol, ≥98%
Odor: alliaceous (onion, garlic) |
Certified Food Grade Products |
Synerzine |
1-Butanethiol
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Taytonn ASCC |
Butyl Mercaptan
Odor: Cabbage, Earthy, Onion, Sulphurous |
TCI AMERICA |
For experimental / research use only. |
1-Butanethiol >97.0%(GC)
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Tengzhou Jitian Aroma Chemiclal |
Butyl Mercaptan
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United International |
1-Butanethiol
|
WholeChem |
1-Butanethiol
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 11 - Highly flammable. R 20/22 - Harmful by inhalation and if swallowed. R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 20/21 - When using do not eat, drink or smoke. S 23 - Do not breath vapour. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
gavage-rat LD50 1500 mg/kg (Fairchild & Stokinger, 1958)
intraperitoneal-rat LD50 399 mg/kg BEHAVIORAL: COMA
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY American Industrial Hygiene Association Journal. Vol. 19, Pg. 171, 1958.
oral-mouse LD50 3000 mg/kg "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol.Pg.982, 1986
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
inhalation-rat LC50 4020 ppm/4H LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE American Industrial Hygiene Association Journal. Vol. 19, Pg. 171, 1958.
inhalation-mouse LC50 2500 ppm/4H BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE American Industrial Hygiene Association Journal. Vol. 19, Pg. 171, 1958.
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Safety in Use Information:
Category: | flavoring agents |
Recommendation for butyl mercaptan usage levels up to: | | not for fragrance use.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.39 (μg/capita/day) |
Structure Class: | I |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 10 |
Click here to view publication 10 |
| average usual ppm | average maximum ppm |
baked goods: | - | - |
beverages(nonalcoholic): | - | - |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | - |
fruit ices: | - | - |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | 0.02000 |
hard candy: | - | - |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | 0.02000 |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | 0.02000 |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | 0.02000 |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Flavouring Group Evaluation 8 (FGE.08)[1]: Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20 View page or View pdf |
Flavouring Group Evaluation 8, Revision 1 (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 08, Revision 4 (FGE.08Rev4): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
EPI System: | View |
NIOSH International Chemical Safety Cards: | search |
NIOSH Pocket Guide: | search |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 109-79-5 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 8012 |
National Institute of Allergy and Infectious Diseases: | Data |
WISER: | UN 3336 |
WGK Germany: | 3 |
| butane-1-thiol |
Chemidplus: | 0000109795 |
EPA/NOAA CAMEO: | hazardous materials |
RTECS: | 109-79-5 |
References:
Other Information:
Potential Blenders and core components note
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For Odor |
alliaceous |
| dibutyl sulfide | FL/FR |
| dimethyl trisulfide | FL/FR |
| methyl furfuryl disulfide | FL/FR |
chocolate |
2,5- | dimethyl pyrazine | FL/FR |
2,6- | dimethyl pyrazine | FL/FR |
fermented |
| ethyl (E)-2-crotonate | FL/FR |
herbal |
| trigonella foenum-graecum seed extract | FL/FR |
| sulfurol | FL/FR |
| sulfuryl acetate | FL/FR |
moldy |
| strawberry furanone methyl ether | FL/FR |
2,4,5- | trimethyl oxazole | FL/FR |
spicy |
| ethyl vinyl ketone | FL/FR |
| ethyl 2-mercaptopropionate | FL/FR |
| ethyl methyl mercaptopropionate | FL/FR |
| furfuryl thioacetate | FL/FR |
2- | methyl 5-(methyl thio) furan | FL/FR |
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For Flavor |
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No flavor group found for these |
gamma- | aminobutyric acid | FL |
| benzyl methyl sulfide | FL |
2-( | methyl thio) methyl-2-butenal | FL |
1,9- | nonane dithiol | FL |
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N-(2-(3,4- | dimethoxyphenyl)ethyl)-3,4-dimethoxycinnamic acid amide | FL |
2,4- | dimethyl-3-oxazoline | FL |
1-(2- | thienyl) butanone | FL |
alliaceous |
| allyl disulfide | FL |
| allyl mercaptan | FL |
| allyl thiopropionate | FL |
| cyclopentyl mercaptan | FL |
| dicyclohexyl disulfide | FL |
| dimethyl trisulfide | FL/FR |
3- | mercapto-2-pentanone | FL |
2- | methyl thioacetaldehyde | FL |
3- | tetrahydrothiophenone | FL |
| truffle sulfide | FL |
bready |
| trigonella foenum-graecum seed extract | FL/FR |
burnt |
2,4,5- | trimethyl oxazole | FL/FR |
chemical |
2,5- | dimethyl furan | FL |
coffee |
2,4- | dimethyl thiazole | FL |
| methyl furfuryl disulfide | FL/FR |
green |
| dibutyl sulfide | FL/FR |
meaty |
2,6- | dimethyl pyrazine | FL/FR |
3- | mercapto-2-butanone | FL |
(R,S)-2- | mercapto-3-butanol | FL |
2- | methyl 3-(methyl thio) furan | FL |
bis(2- | methyl-3-furyl) disulfide | FL |
2- | methyl-3-tetrahydrofuran thiol | FL |
2- | pyridinyl methane thiol | FL |
| sulfurol | FL/FR |
| sulfuryl acetate | FL/FR |
ortho- | thiocresol | FL |
moldy |
| strawberry furanone methyl ether | FL/FR |
musty |
2,5- | dimethyl pyrazine | FL/FR |
| ethyl (E)-2-crotonate | FL/FR |
2- | methyl 5-(methyl thio) furan | FL/FR |
nutty |
| nutty thiazole | FL |
onion |
| ethyl 2-mercaptopropionate | FL/FR |
| furfuryl isopropyl sulfide | FL |
| methionol | FL |
| methyl propyl disulfide | FL |
| methyl propyl trisulfide | FL |
| propyl thioacetate | FL |
roasted |
| furfuryl thioacetate | FL/FR |
| hexyl mercaptan | FL |
savory |
N1-(2- | methoxy-4-methyl benzyl)-N2-2(2-(5-methyl pyridin-2-yl)ethyl) oxalamide | FL |
seafood |
1,4- | dithiane | FL |
spicy |
| ethyl vinyl ketone | FL/FR |
sulfurous |
| allyl sulfide | FL |
| ethyl methyl mercaptopropionate | FL/FR |
| ethyl methyl sulfide | FL |
S- | ethyl thioacetate | FL |
| furfuryl thiopropionate | FL |
3- | mercapto-2-methyl pentanal | FL |
| methyl 2-methyl-3-furyl disulfide | FL |
| methyl benzyl disulfide | FL |
3- | methyl-2-butane thiol | FL |
| roasted butanol | FL |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| bear skunk | 1- | butane thiol | | butane-1-thiol | 1- | butanethiol | 1- | butyl mercaptan | N- | butyl mercaptan | | butyl mercaptan synthetic | | butyl sulfide | | butyl sulphide | | butyl thioalcohol | | butyl thiol | N- | butyl-sulfide | 1- | mercaptobutane | | thiobutyl alcohol |
Articles:
PubMed: | Development of a quantitative approach using surface-enhanced Raman chemical imaging: first step for the determination of an impurity in a pharmaceutical model. |
PubMed: | Community Health Assessment Following Mercaptan Spill: Eight Mile, Mobile County, Alabama, September 2012. |
PubMed: | Stability of volatile sulfur compounds (VSCs) in sampling bags - impact of temperature. |
PubMed: | Determination of Lewisites and their hydrolysis products in aqueous and multiphase samples by in-sorbent tube butyl thiolation followed by thermal desorption-gas chromatography-full scan mass spectrometry. |
PubMed: | Oxygen attachment on alkanethiolate SAMs induced by low-energy electron irradiation. |
PubMed: | Electrochemical gas sensors based on paper-supported room-temperature ionic liquids for improved analysis of acid vapours. |
PubMed: | Analysis of thiols by microchip capillary electrophoresis for in situ planetary investigations. |
PubMed: | Ion-molecule reactions for the differentiation of primary, secondary and tertiary hydroxyl functionalities in protonated analytes in a tandem mass spectrometer. |
PubMed: | An electrochemical gas sensor based on paper supported room temperature ionic liquids. |
PubMed: | Aqueous photoreduction of oxidized mercury species in presence of selected alkanethiols. |
PubMed: | A cataluminescence gas sensor based on nanosized V2O5 for tert-butyl mercaptan. |
PubMed: | Synthesis of thiol capped CdS nanocrystallites using microwave irradiation and studies on their steady state and time resolved photoluminescence. |
PubMed: | Principles of detecting vaporous thiols using liquid crystals and metal ion microarrays. |
PubMed: | Kinetic and theoretical study of the reaction of Cl atoms with a series of linear thiols. |
PubMed: | A new efficient enantioselective synthesis of (+)-cis-2-methyl-4-propyl-1,3-oxathiane, a valuable ingredient for the aroma of passion fruit. |
PubMed: | Conformationally specific vacuum ultraviolet mass-analyzed threshold ionization spectroscopy of alkanethiols: structure and ionization of conformational isomers of ethanethiol, isopropanethiol, 1-propanethiol, tert-butanethiol, and 1-butanethiol. |
PubMed: | Determination of volatile organic sulfur compounds in the air at sewage management areas by thermal desorption and gas chromatography-mass spectrometry. |
PubMed: | A micromachined surface stress sensor with electronic readout. |
PubMed: | [Determination and distribution of sulfur compounds in coked gasoline by gas chromatography-sulfur chemiluminescence detection]. |
PubMed: | Electrochemical factors controlling the patterning of metals on SAM-coated substrates. |
PubMed: | Synthesis of hydroxy thio-ether derivatives of vegetable oil. |
PubMed: | [Determination of sulfur compounds in fluid catalytic cracking gasoline by gas chromatography with a sulfur chemiluminescence detector]. |
PubMed: | On-column derivatization-capillary electrochromatography with o-phthalaldehyde/alkylthiol for assay of biogenic amines. |
PubMed: | Volatile components in defensive spray of the hooded skunk, Mephitis macroura. |
PubMed: | NEXAFS study of 1-butanethiol adsorbed on Cu(111) and square root of 7 x square root of 7 R19.1 degrees S/Cu(111). |
PubMed: | Effects of the sniffing port air makeup in gas chromatography-olfactometry. |
PubMed: | Inter- and intramolecular pathways for the formation of tetrahydrofurans from beta-(Phosphatoxy)alkyl radicals. Evidence for a dissociative mechanism |
PubMed: | Determination of sulphur compounds in beer using headspace solid-phase microextraction and gas chromatographic analysis with pulsed flame photometric detection. |
PubMed: | [Hygienic assessment of damaging exposure of schoolchildren to butyl mercaptan]. |
PubMed: | Mortality following cotton defoliation: San Joaquin Valley, California, 1970-1990. |
PubMed: | Metabolic fate of S,S,S-tributyl phosphorotrithioate (DEF) in the lactating goat. |
PubMed: | Volatile components in defensive spray of the hog-nosed skunk,Conepatus mesoleucus. |
PubMed: | Volatile components in defensive spray of the spotted skunk,Spilogale putorius. |
PubMed: | New components in defensive secretion of the striped skunk,Mephitis mephitis. |
PubMed: | Oxidation of thiols by sodium N-haloarylsulphonamides. |
PubMed: | Mercaptans decrease selenium-dependent glutathione peroxidase activity in the chick. |
PubMed: | Inhalation teratology studies of n-butyl mercaptan in rats and mice. |
PubMed: | Antioxidant enzyme activities and malondialdehyde, glutathione and methemoglobin concentrations in channel catfish exposed to DEF and n-butyl mercaptan. |
PubMed: | Liquid chromatographic-fluorescence determination of ammonia from nitrogenase reactions: a 2-min assay. |
PubMed: | Heinz body production and hematological changes in the hen after administration of a single oral dose of n-butyl mercaptan and n-butyl disulfide. |
PubMed: | Butyl mercaptan poisoning in the Parnell civil defence emergency: fact or fiction. |
PubMed: | Reactions of mercaptans with cytochrome c oxidase and cytochrome c. |
PubMed: | Delayed neurotoxic, late acute and cholinergic effects of S,S,S-tributyl phosphorotrithioate (DEF): subchronic (90 days) administration in hens. |
PubMed: | Specific inhibition of sclerotium formation by 2-mercaptoethanol and related sulfhydryl compounds in Sclerotium rolfsii. |
PubMed: | The incidence and probable inheritance of smell blindness to normal butyl mercaptan. |
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