cinnamomum cassia bark extract
extract obtained from the dried bark of the chinese cinnamon, cinnamomum cassia (l.), lauraceae
 
Notes:
Use with Caution and in only very small quantites.
  • Robertet
  • Vigon International
    • Vigon International
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      Product(s):
      504462 Cinnamon Co2 Extract
       
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Name: cinnamomum cassia blume bark extract
CAS Number: 84961-46-6 
ECHA EC Number: 284-635-0
Category: cosmetic, flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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FEMA Number: 2257 cassia bark extract
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Regulation:
FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart A--General Provisions
Sec. 182.20 Essential oils, oleoresins (solvent-free), and natural extractives (including distillates).
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor Type: spicy
 
 cassia  cinnamon  
Odor Description:
at 100.00 %. 
cassia
 
 
Flavor Type: spicy
 
 cassia  cinnamon  
Taste Description:
cassia
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: fragrance
hair conditioning
oral care agents
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Suppliers:
Bio-Botanica®
Cinnamon Bark Cinnamomum Cassia Bark Extract
Bio-Botanica®
Cinnamon, FE – 5029
Carrubba
cinnamon cassia extract
Robertet
CANNELLE éCORCES CHINE
Pur & Nat
Seasons and Harvest / Crop calendar
Solabia
SEBUSTOP®
Odor: characteristic
Use: Because of its high tannin, essential oils and saponin content, Sebustop® provides an ideal treatment for short-term reduction of excess sebum, cleansing and purifying the skin, revealing its radiance.
Vigon International
Cinnamon Co2 Extract
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic, flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect: Dermal sensitization and systemic toxicity
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
benzaldehyde Max. Found: 1.00 % and Reason: Sensitization
benzyl benzoate Max. Found: 0.07 % and Reason: Sensitization
cinnamyl alcohol Max. Found: 0.5 % and Reason: Sensitization
cinnamaldehyde Max. Found: 44.00 % and Reason: Sensitization
coumarin Max. Found: 0.15 % and Reason: Sensitization
eugenol Max. Found: 0.03 % and Reason: Sensitization
ortho-methoxycinnamaldehyde Max. Found: 2.00 % and Reason: Sensitization
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -10.00000
beverages(nonalcoholic): -310.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -10.00000
fruit ices: -10.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -10.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
ClinicalTrials.gov: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 cinnamomum cassia blume bark extract
Chemidplus: 0084961466
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References:
 cinnamomum cassia blume bark extract
Pubchem (sid): 135310975
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Other Information:
FDA Substances Added to Food (formerly EAFUS): View
Export Tariff Code: 1302.19.0000
MedlinePlusSupp: View
Wikipedia: View
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Potential Blenders and core components note
 
For Odor
balsamic
balsamic
 cinnamyl cinnamateFL/FR
 cinnamyl formateFL/FR
 linalyl cinnamateFL/FR
 peru balsam oilFL/FR
 peru balsam resinoidFL/FR
2-phenoxyethyl formateFR
3-phenyl propyl alcoholFL/FR
citrus
 citronitrile (Symrise)FR
floral
3-phenyl propionic acidFL/FR
3-phenyl propyl formateFL/FR
fruity
para-tolualdehydeFL/FR
green
 biphenyl 
3-hexenalFL/FR
 sorbyl isobutyrateFL/FR
honey
 methyl hydrocinnamateFL/FR
phenolic
2'-hydroxyacetophenoneFL/FR
spicy
 allspice berry absoluteFL/FR
 allspice leaf oilFL/FR
 allspice leaf oil terpenelessFL/FR
 allspice oilFL/FR
 allspice oleoresinFL/FR
 apple spice fragranceFR
 canella bark oilFR
 canella winterana 
 cassia bark concreteFR
saigon cassia bark oilFL/FR
 cassia bark oil chinaFL/FR
 cassia bark oil CO2 extractFL/FR
 cassia bark oil indonesiaFL/FR
 cassia bark oil replacerFL/FR
 cassia bark oleoresinFL/FR
 cassia buds 
 cassia fragranceFR
 cassia leaf oilFL/FR
 cassia oil terpenesFR
(Z)-cinnamaldehydeFL/FR
 cinnamaldehydeFL/FR
(E)-cinnamaldehydeFL/FR
 cinnamaldehyde / methyl anthranilate schiff's baseFR
 cinnamaldehyde butylene glycol acetal 
 cinnamaldehyde diethyl acetalFL/FR
 cinnamaldehyde dimethyl acetalFL/FR
 cinnamaldehyde ethylene glycol acetalFL/FR
 cinnamaldehyde propylene glycol acetalFL/FR
 cinnamomum cassia bark absoluteFL/FR
 cinnamomum cassia leaf extractFR
 cinnamomum cassia oilFL/FR
 cinnamomum cassia tinctureFL/FR
 cinnamomum verum bark extract ceylonFL/FR
 cinnamomum verum waterFL/FR
 cinnamomum zeylanicum bark powderCS
 cinnamomum zeylanicum leaf extract ceylonFR
 cinnamon acroleinFL/FR
 cinnamon bark oilFL/FR
 cinnamon bark oil (cinnamomum zeylanicum) indiaFL/FR
 cinnamon bark oil (cinnamomum zeylanicum) sri laukaFL/FR
 cinnamon bark oil ceylonFL/FR
 cinnamon bark oil CO2 extractFL/FR
 cinnamon bark oil replacerFR
 cinnamon cookie fragranceFR
 cinnamon fragranceFR
 cinnamon fruit oil indiaFR
 cinnamon infusionsFL/FR
 cinnamon leaf oil ceylonFL/FR
 cinnamon leaf oil replacerFR
 cinnamon oleoresin ceylonFL/FR
 cinnamon twig oil indiaFL/FR
 cinnamyl acetateFL/FR
 cinnamyl nitrileFR
(E)-cinnamyl nitrileFR
 croton eluteria bark oilFL/FR
 eugenolFL/FR
3-(2-furyl) acroleinFL/FR
para-methoxy-alpha-methyl cinnamaldehydeFL/FR
ortho-methoxycinnamaldehydeFL/FR
(E)-para-methoxycinnamaldehydeFL/FR
para-methoxycinnamaldehydeFL/FR
alpha-methyl cinnamaldehydeFL/FR
 methyl eugenolFR
 methyl heptadienoneFL/FR
alpha-methyl-(E)-cinnamaldehydeFL/FR
 myrtenalFL/FR
 spicy acetoacetateFL/FR
woody
 cyperus root oil (cyperus scariosus)FR
 
For Flavor
 
No flavor group found for these
 cinnamaldehyde butylene glycol acetal 
2-furfurylidene butyraldehydeFL
3-(2-furyl) acroleinFL/FR
para-methoxy-alpha-methyl cinnamaldehydeFL/FR
(E)-para-methoxycinnamaldehydeFL/FR
 methyl hydrocinnamateFL/FR
3-phenyl propionic acidFL/FR
3-phenyl propyl formateFL/FR
 sorbyl isobutyrateFL/FR
balsamic
 peru balsam oilFL/FR
 peru balsam resinoidFL/FR
cherry
para-methoxycinnamaldehydeFL/FR
cookie
cinnamon sugar cookie flavorFL
creamy
 dihydrocoumarinFL
floral
 biphenyl 
fruity
 linalyl cinnamateFL/FR
green
3-hexenalFL/FR
 methyl heptadienoneFL/FR
minty
 myrtenalFL/FR
(1R)-(-)-myrtenalFL
naphthyl
2'-hydroxyacetophenoneFL/FR
nutty
 furfural acetoneFL
spicy
 allspice berry absoluteFL/FR
 allspice flavorFL
 allspice leaf oilFL/FR
 allspice leaf oil terpenelessFL/FR
 allspice oilFL/FR
 allspice oleoresinFL/FR
 apple cinnamon french toast flavorFL
 benzylidene acetoneFL
 blueberry cinnamon crumble flavorFL
 canella winterana 
saigon cassia bark oilFL/FR
 cassia bark oil chinaFL/FR
 cassia bark oil CO2 extractFL/FR
 cassia bark oil indonesiaFL/FR
 cassia bark oil replacerFL/FR
 cassia bark oleoresinFL/FR
 cassia buds 
 cassia flavorFL
 cassia leaf oilFL/FR
 chocolate cinnamon hazelnut flavorFL
 cinnamaldehydeFL/FR
(E)-cinnamaldehydeFL/FR
(Z)-cinnamaldehydeFL/FR
 cinnamaldehyde diethyl acetalFL/FR
 cinnamaldehyde dimethyl acetalFL/FR
 cinnamaldehyde ethylene glycol acetalFL/FR
 cinnamaldehyde propylene glycol acetalFL/FR
 cinnamomum burmannii extract padang or bataviaFL
 cinnamomum cassia bark absoluteFL/FR
 cinnamomum cassia bark powderFL
 cinnamomum cassia oilFL/FR
 cinnamomum cassia tinctureFL/FR
saigon cinnamomum loureirii bark extractFL
 cinnamomum verum bark extract ceylonFL/FR
 cinnamomum verum waterFL/FR
 cinnamonFL
 cinnamon acroleinFL/FR
 cinnamon bark oilFL/FR
 cinnamon bark oil (cinnamomum zeylanicum) indiaFL/FR
 cinnamon bark oil (cinnamomum zeylanicum) sri laukaFL/FR
 cinnamon bark oil ceylonFL/FR
 cinnamon bark oil CO2 extractFL/FR
 cinnamon butter pecan flavorFL
toasted cinnamon cashew flavorFL
red hot cinnamon flavorFL
 cinnamon flavorFL
 cinnamon hazelnut cappuccino flavorFL
 cinnamon hazelnut cream flavorFL
 cinnamon infusionsFL/FR
 cinnamon leaf oil ceylonFL/FR
 cinnamon nut butter rum flavorFL
 cinnamon nut cream flavorFL
 cinnamon oleoresin ceylonFL/FR
toasted cinnamon pecan flavorFL
 cinnamon powderFL
 cinnamon twig oil indiaFL/FR
 cinnamyl acetateFL/FR
 cinnamyl cinnamateFL/FR
 cinnamyl formateFL/FR
 croton eluteria bark oilFL/FR
 eugenolFL/FR
ortho-methoxycinnamaldehydeFL/FR
alpha-methyl cinnamaldehydeFL/FR
alpha-methyl-(E)-cinnamaldehydeFL/FR
3-phenyl propyl alcoholFL/FR
 spicy acetoacetateFL/FR
cinnamon tea flavorFL
para-tolualdehydeFL/FR
 
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Potential Uses:
 baisers du printemps 
 buckingham flowers 
 couronne de fleurs 
 fiori d'italia 
 fleurs des champs 
 hair conditioning 
 huntsman's nosegay 
 oral care agents 
 rose dog roseFR
 rose white roseFR
 wallflowerFR
 wintergreenFR
 yacht club 
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Occurrence (nature, food, other): note
 cassia
Search Trop  Picture
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Synonyms:
 camphorina cassia bark extract
 cannelle écorces bark extract
 cassia bark extract
 cinnamomum aromaticum bark extract
 cinnamomum longifolium bark extract
 cinnamomum medium bark extract
 cinnamomum nitidum bark extract
 cinnamon cassia bark extract
 extract obtained from the dried bark of the chinese cinnamon, cinnamomum cassia (l.), lauraceae
 laurus cassia bark extract
 persea cassia bark extract
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Articles:
PubMed: Agrimonia pilosa Ledeb., Cinnamomum cassia Blume, and Lonicera japonica Thunb. protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance in β-amyloid-infused rats.
PubMed: Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) Can Ameliorate Cyclophosphamide-induced Ongoing Bladder Overactivity and Acidic Adenosine Triphosphate Solution-induced Hyperactivity on Rats Prestimulated Bladder.
PubMed: Cinnamomum cassia Suppresses Caspase-9 through Stimulation of AKT1 in MCF-7 Cells but Not in MDA-MB-231 Cells.
PubMed: Cinnamaldehyde affects the biological behavior of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signaling pathway.
PubMed: In Vitro Antiviral Activity of Cinnamomum cassia and Its Nanoparticles Against H7N3 Influenza A Virus.
PubMed: Cinnamomum cassia: an implication of serotonin reuptake inhibition in animal models of depression.
PubMed: Cinnamon and its Components Suppress Vascular Smooth Muscle Cell Proliferation by Up-Regulating Cyclin-Dependent Kinase Inhibitors.
PubMed: Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida albicans, Candida glabrata and Candida krusei Clinical Isolates.
PubMed: Anti-diabetic nephropathy compounds from Cinnamomum cassia.
PubMed: Immunosuppressive Effects of A-Type Procyanidin Oligomers from Cinnamomum tamala.
PubMed: Cinnamomum cassia bark produced by solid-state fermentation with Phellinus baumii has the potential to alleviate atopic dermatitis-related symptoms.
PubMed: A new phenolic glycoside from the barks of Cinnamomum cassia.
PubMed: Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia.
PubMed: Traditional formula, modern application: chinese medicine formula sini tang improves early ventricular remodeling and cardiac function after myocardial infarction in rats.
PubMed: Effect of Cinnamomum cassia methanol extract and sildenafil on arginase and sexual function of young male Wistar rats.
PubMed: Evaluation of the in vitro anti-hyperglycemic effect of Cinnamomum cassia derived phenolic phytochemicals, via carbohydrate hydrolyzing enzyme inhibition.
PubMed: Interaction of gypsum and the rhizome of Anemarrhena asphodeloides plays an important role in anti-allergic effects of byakkokakeishito in mice.
PubMed: Cinnamaldehyde/chemotherapeutic agents interaction and drug-metabolizing genes in colorectal cancer.
PubMed: Identification of compounds from the water soluble extract of Cinnamomum cassia barks and their inhibitory effects against high-glucose-induced mesangial cells.
PubMed: A novel concept for detoxification: complexation between aconitine and liquiritin in a Chinese herbal formula ('Sini Tang').
PubMed: Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signaling.
PubMed: Fumigant toxicity of plant essential oils against Camptomyia corticalis (Diptera: Cecidomyiidae).
PubMed: Antioxidant activity of various parts of Cinnamomum cassia extracted with different extraction methods.
PubMed: Bioactive A-type proanthocyanidins from Cinnamomum cassia.
PubMed: Differential antiproliferation effect of 2'-benzoyloxycinnamaldehyde in K-ras-transformed cells via downregulation of thiol antioxidants.
PubMed: 2'-Hydroxycinnamaldehyde targets low-density lipoprotein receptor-related protein-1 to inhibit lipopolysaccharide-induced microglial activation.
PubMed: Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks.
PubMed: Platelet anti-aggregation activities of compounds from Cinnamomum cassia.
PubMed: Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves.
PubMed: The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells.
PubMed: Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1.
PubMed: Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential.
PubMed: Selective stimulation by cinnamaldehyde of progesterone secretion in human adrenal cells.
PubMed: Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways.
PubMed: Cinnamic acid, from the bark of Cinnamomum cassia, regulates glucose transport via activation of GLUT4 on L6 myotubes in a phosphatidylinositol 3-kinase-independent manner.
PubMed: [Analysis on the chemical compositions of the volatile oil from ultramicro-powder and common grinding powder of Cinnamomum cassia].
PubMed: Quality assessment of cortex cinnamomi by HPLC chemical fingerprint, principle component analysis and cluster analysis.
PubMed: Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells.
PubMed: Nematicidal Activity of Cassia and Cinnamon Oil Compounds and Related Compounds toward Bursaphelenchus xylophilus (Nematoda: Parasitaphelenchidae).
PubMed: Stimulatory effects of extract prepared from the bark of Cinnamomum cassia blume on the function of osteoblastic MC3T3-E1 cells.
PubMed: Repellency of Cinnamomum cassia bark compounds and cream containing cassia oil to Aedes aegypti (Diptera: Culicidae) under laboratory and indoor conditions.
PubMed: In vitro efficacy of 75 essential oils against Aspergillus niger.
PubMed: Antimicrobial effects of selected plant essential oils on the growth of a Pseudomonas putida strain isolated from meat.
PubMed: Antimicrobial activities of cinnamon oil and cinnamaldehyde from the Chinese medicinal herb Cinnamomum cassia Blume.
PubMed: Delayed occurrence of H-ras12V-induced hepatocellular carcinoma with long-term treatment with cinnamaldehydes.
PubMed: Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver.
PubMed: Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro.
PubMed: Authentication and quantitative analysis on the chemical profile of cassia bark (cortex cinnamomi) by high-pressure liquid chromatography.
PubMed: Inhibitory effect of 2'-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells.
PubMed: Inhibition of Trypanosoma cruzi by plant extracts used in Chinese medicine.
PubMed: Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia.
PubMed: [Isolation of genomic DNA from Cinnamomum cassia Presl].
PubMed: Repellency of aromatic medicinal plant extracts and a steam distillate to Aedes aegypti.
PubMed: Inhibitory effect of Sihoga-Yonggol-Moryo-Tang on matrix metalloproteinase-2 and -9 activities and invasiveness potential of hepatocellular carcinoma.
PubMed: Antioxidant activity of Cinnamomum cassia.
PubMed: Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells.
PubMed: Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat.
PubMed: [Comparison studies on chemical constituents of essential oil from Ramulus Cinnamomi and Cortex Cinnamomi by GC-MS].
PubMed: Inhibitory activity of Cinnamomum cassia bark-derived component against rat lens aldose reductase.
PubMed: Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase.
PubMed: Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties.
PubMed: Growth-Inhibiting Effects of Cinnamomum cassia Bark-Derived Materials on Human Intestinal Bacteria.
PubMed: A survey of some Indian medicinal plants for anti-human immunodeficiency virus (HIV) activity.
PubMed: Extract prepared from the bark of Cinnamomum cassia Blume prevents glutamate-induced neuronal death in cultured cerebellar granule cells.
PubMed: Insecticidal and fumigant activities of Cinnamomum cassia bark-derived materials against Mechoris ursulus (Coleoptera: attelabidae).
PubMed: Synthesis and in vitro cytotoxicity of cinnamaldehydes to human solid tumor cells.
PubMed: Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation.
PubMed: 2'-Hydroxycinnamaldehyde from stem bark of Cinnamomum cassia.
PubMed: Pharmacotherapeutic effects of kuei-chih-fu-ling-wan (keishi-bukuryo-gan) on human uterine myomas.
PubMed: A reticuloendothelial system-activating arabinoxylan from the bark of Cinnamomum cassia.
PubMed: Antiulcerogenic compounds isolated from Chinese cinnamon.
PubMed: Effects of a Chinese herbal medicine, keishi-bukuryo-gan, on the gonadal system of rats.
PubMed: [Pharmacological studies of Cinnamomum cassia bark. Part I. Effects on the blood and cardiovascular system (author's transl)].
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