Category: cosmetic, flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | white crystalline powder (est) |
Assay: | 98.00 to 100.00 %
|
Heavey Metals: | <40.00 ppm |
Food Chemicals Codex Listed: | Yes |
Melting Point: | 37.00 to 39.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 263.00 to 265.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 144.00 to 145.00 °C. @ 15.00 mm Hg
|
Congealing Point: | 35.30 °C.
|
Acid Value: | 3.00 max. KOH/g
|
Vapor Pressure: | 0.003000 mmHg @ 25.00 °C. |
Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
|
logP (o/w): | 1.050 |
Shelf Life: | 24.00 month(s) or longer if stored properly. |
Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
Soluble in: |
| alcohol | | benzyl benzoate | | dipropylene glycol | | fixed oils | | isopropyl myristate | | propylene glycol | | water, 3500 mg/L @ 25 °C (exp) |
Insoluble in: |
| paraffin oil | | glycerin |
Stability: |
| bath foam | | hair spray | | powder | | soap |
Organoleptic Properties:
|
Odor Type: floral |
|
Odor Strength: | medium |
|
Substantivity: | 212 hour(s) at 100.00 % |
|
| heliotrope sweet powdery coconut vanilla |
Odor Description: at 100.00 %. | heliotrope flower sweet powdery coconut vanilla Luebke, William tgsc, (1982) |
|
| cherry vanilla sweet cherry maraschino cherry creamy cinnamyl |
Odor Description:
| Cherry, vanilla, sweet cherry pit notes and creamy with cinnamic nuances Mosciano, Gerard P&F 21, No. 5, 49, (1996) |
|
|
Flavor Type: cherry |
|
| cherry maraschino cherry cherry vanilla spicy |
Taste Description: at 15.00 ppm. | Benzaldehyde, cherry, vanilla and spicy Mosciano, Gerard P&F 21, No. 5, 49, (1996) |
|
Odor and/or flavor descriptions from others (if found). |
|
Takasago |
Heliotropin 99% as Piperonal |
Odor Description: | Cherry-like Widely used in perfumery. Used in powdery accords, but also in florals, like muguet, carnation, and lilac. Give softness and creaminess. |
Taste Description: | sweet creamy nutty benzaldehyde vanilla spice |
|
Sigma-Aldrich |
Piperonal, ≥99%, FCC, FG |
Odor Description: | almond; anise; balsam; berry; cherry; creamy; floral; raspberry; sweet; vanilla; violet; woody; wine-like; herbaceous |
Taste Description: | sweet creamy nutty benzaldehyde vanilla spice |
|
Moellhausen |
PIPERONAL |
Odor Description: | sweet, vanilla |
Taste Description: | sweet, aromatic, vanilla, benzaldehyde |
|
Alfrebro |
Heliotropin, Natural |
Odor Description: | Heliotrope Flower Sweet Coconut |
|
|
Cosmetic Information:
Suppliers:
Advanced Biotech |
HELIOTROPINE NATURAL
98% min. |
Advanced Biotech |
HELIOTROPINE SYNTHETIC
|
Alfrebro |
Heliotropin, Natural
Odor: Heliotrope Flower Sweet Coconut |
Associate Allied Chemicals |
Heliotropin
|
About |
Augustus Oils |
Heliotropin
|
Services |
Aurochemicals |
HELIOTROPINE, Natural
|
Axxence Aromatic |
HELIOTROPIN Natural
Kosher |
Sustainability |
Bell Flavors & Fragrances |
Heliotropine
|
Bell Flavors & Fragrances |
Natural Heliotropine (EU)
|
Bell Flavors & Fragrances |
Natural Heliotropine
|
Berjé |
Heliotropine
|
Media |
BOC Sciences |
For experimental / research use only. |
Piperonal
|
Bontoux |
HELIOTROPINE
|
Charkit Chemical |
PIPERONAL
|
Citrus and Allied Essences |
Heliotropin Recrystallized Extra FCC
|
Market Report |
ECSA Chemicals |
HELIOTROPIN (PIPERONAL)
|
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
Ernesto Ventós |
PIPERONAL (HELIOTROPINE) NATURAL
|
Ernesto Ventós |
PIPERONAL (HELIOTROPINE)
Odor: SWEET, FLORAL |
Excellentia International |
Heliotropin Natural
|
Fleurchem |
heliotropin natural
|
Fleurchem |
heliotropin
|
Foreverest Resources |
Heliotropin
Odor: cherry-like Use: It is naturally found in various plants,including dill, vanilla, violet flowers, and black pepper,etc. |
Frey + Lau |
Heliotropin
Odor: Sweet, narcotic, balsamic |
Frinton Laboratories |
For experimental / research use only. |
Piperonal
|
Global Essence |
Heliotropine
|
Indenta Group |
Heliotropin
|
Indukern F&F |
PIPERONAL
Odor: SWEET, VANILLA |
K.L. Koh Enterprise |
HELIOTOPIN
|
Lluch Essence |
PIPERONAL CRYST.
|
Lluch Essence |
PIPERONAL FLAKES
|
Lluch Essence |
PIPERONAL NATURAL
|
M&U International |
HELIOTROPIN
|
M&U International |
NAT. HELIOTROPIN
|
Moellhausen |
HELIOBASE (25%PG)
|
Moellhausen |
HELIOBASE (30% PG)
|
Moellhausen |
HELIOBASE (30%DPG)
Odor: sweet, vanilla |
Moellhausen |
HELIOBASE (43% DIACETIN)
|
Moellhausen |
HELIOBASE (50% TRIACETINA)
|
Moellhausen |
HELIOBASE (50%DEP)
|
Moellhausen |
HELIOBASE (50%DPG)
Odor: sweet, vanilla |
Moellhausen |
HELIOBASE (50%PG)
|
Moellhausen |
HELIOBASE 14%PG
|
Moellhausen |
HELIOBASE 50% IPM
|
Moellhausen |
PIPERONAL NAT.
|
Moellhausen |
PIPERONAL
Odor: sweet, vanilla Flavor: sweet, aromatic, vanilla, benzaldehyde |
O'Laughlin Industries |
HELIOTROPINE US NATURAL
|
O'Laughlin Industries |
HELIOTROPINE
|
Oamic Ingredients |
Heliotropin (Piperonal) Natural
EU Natural Odor: French style vanilla, sweet, floral, powdery |
Omega Ingredients |
Heliotropin Natural 98% minimum
|
OQEMA |
Heliotropin
|
PCW France |
Heliotropin
|
Steps to a fragranced product |
Penta International |
HELIOTROPIN 30% IN TRIACETIN
|
Penta International |
HELIOTROPIN FCC
|
Penta International |
HELIOTROPIN NATURAL
|
Perfumer Supply House |
Heliotropin Crystals (Piperonal) – for a limited time only
|
Phoenix Aromas & Essential Oils |
Heliotropine Natural
|
Phoenix Aromas & Essential Oils |
Heliotropine
|
Prinova |
Heliotropin
|
Quimdis |
Heliotropine / Piperonal
|
R C Treatt & Co Ltd |
Heliotropine
|
Reincke & Fichtner |
Heliotropin natural
|
Reincke & Fichtner |
Heliotropin
|
Sigma-Aldrich |
Piperonal, ≥99%, FCC, FG
Odor: almond; anise; balsam; berry; cherry; creamy; floral; raspberry; sweet; vanilla; violet; woody; wine-like; herbaceous |
Certified Food Grade Products |
Sigma-Aldrich |
Piperonal, natural, 98%, FG
Odor: floral |
SRS Aromatics |
HELIOTROPIN
|
Symphony Pharma |
For experimental / research use only. |
benzo[d][1,3]dioxole-5-carbaldehyde
|
The John D. Walsh Company |
Heliotropine
|
The Lermond Company |
HELIOTROPINE (DEA)
|
The Lermond Company |
HELIOTROPINE, NATURAL (DEA)
|
Vigon International |
Heliotropine Crystals Synthetic ex Sassafras
|
Vigon International |
Heliotropine Crystals
|
Vigon International |
Heliotropine Natural
|
WEN International |
HELIOTROPIN Natural
|
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
|
|
Hazards identification |
|
Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
Skin irritation (Category 2), H315 Acute aquatic toxicity (Category 3), H402 Chronic aquatic toxicity (Category 3), H412
|
GHS Label elements, including precautionary statements |
|
Pictogram | |
|
Signal word | Warning |
Hazard statement(s) |
H315 - Causes skin irritation H402 - Harmful to aquatic life H412 - Harmful to aquatic life with long lasting effects
|
Precautionary statement(s) |
P264 - Wash skin thouroughly after handling. P273 - Avoid release to the environment. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P302 + P352 - IF ON SKIN: wash with plenty of soap and water. P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention. P362 - Take off contaminated clothing and wash before reuse. P501 - Dispose of contents/ container to an approved waste disposal plant.
|
Human Experience: |
6 % solution: no irritation or sensitization. |
Oral/Parenteral Toxicity: |
gavage-rat LD50 [sex: M,F] 2700 mg/kg (Jenner et al., 1964)
gavage-rat LD50 [sex: M,F] 2700 mg/kg (Taylor et al., 1964)
gavage-rat LD50 [sex: M,F] 2700 mg/kg (Hagan et al., 1965)
intraperitoneal-mouse LD50 480 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 370, 1954.
oral-rat LD50 2700 mg/kg BEHAVIORAL: EXCITEMENT
BEHAVIORAL: ATAXIA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toxicology and Applied Pharmacology. Vol. 6, Pg. 378, 1964.
intraperitoneal-rat LDLo 1500 mg/kg BEHAVIORAL: ATAXIA
BEHAVIORAL: MUSCLE WEAKNESS
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Revue Medicale de la Suisse Romande. Vol. 16, Pg. 449, 1896.
|
Dermal Toxicity: |
skin-rabbit LD50 > 5000 mg/kg National Technical Information Service. Vol. OTS0535062
skin-rat LD50 > 5 mg/kg National Technical Information Service. Vol. OTS0535062
|
Inhalation Toxicity: |
Not determined
|
Safety in Use Information:
Category: | cosmetic, flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for heliotropin usage levels up to: | | 8.0000 % in the fragrance concentrate.
|
|
Maximised Survey-derived Daily Intakes (MSDI-EU): | 1500.00 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 3200.00 (μg/capita/day) |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 3 |
Click here to view publication 3 |
| average usual ppm | average maximum ppm |
baked goods: | - | 18.00000 |
beverages(nonalcoholic): | - | 6.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | 36.00000 |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 7.00000 |
fruit ices: | - | 7.00000 |
gelatins / puddings: | - | 5.80000 |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | 7.40000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s): |
The FEMA GRAS assessment of hydroxyl- and alkoxy-substituted benzyl derivatives used as flavor ingredients. View pdf |
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
EPI System: | View |
Chemical Carcinogenesis Research Information System: | Search |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 120-57-0 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 8438 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 2 |
| 1,3-benzodioxole-5-carbaldehyde |
Chemidplus: | 0000120570 |
EPA/NOAA CAMEO: | hazardous materials |
RTECS: | TO1575000 for cas# 120-57-0 |
References:
Other Information:
Potential Blenders and core components note
|
For Odor |
acidic |
acidic |
| cyclohexyl acetic acid | FL/FR |
aldehydic |
| decanal (aldehyde C-10) | FL/FR |
| dodecanal (aldehyde C-12 lauric) | FL/FR |
10- | undecenal (aldehyde C-11 undecylenic) | FL/FR |
amber |
| ambrette seed oil | FL/FR |
| cistus ladaniferus resinoid | FL/FR |
animal |
| animal carbolactone | FR |
| costus valerolactone | FR |
| indole | FL/FR |
anise |
| anise seed oil colombia | FL/FR |
anisic |
para- | acetanisole | FL/FR |
ortho- | acetanisole | FL/FR |
ortho- | anisaldehyde | FL/FR |
para- | anisaldehyde | FL/FR |
balsamic |
2- | acetyl furan | FL/FR |
iso | amyl benzoate | FL/FR |
| amyris wood oil | FL/FR |
sumatra | benzoin resin | FL/FR |
siam | benzoin resinoid | FL/FR |
sumatra | benzoin resinoid | FL/FR |
| benzophenone | FR |
| benzyl cinnamate | FL/FR |
| benzyl salicylate | FL/FR |
iso | butyl benzoate | FL/FR |
iso | butyl cinnamate | FL/FR |
| cinnamyl alcohol | FL/FR |
| cinnamyl cinnamate | FL/FR |
| clover nitrile | FR |
| copaiba balsam oil | FL/FR |
| ethyl cinnamate | FL/FR |
| fir balsam absolute | FR |
| methyl (E)-cinnamate | FL/FR |
| methyl cinnamate | FL/FR |
| myrrh oil | FL/FR |
| peru balsam oil | FL/FR |
3- | phenyl propyl alcohol | FL/FR |
iso | propyl cinnamate | FL/FR |
| tolu balsam | FL/FR |
| tolu balsam oil | FL/FR |
berry |
| raspberry ketone | FL/FR |
| cyclotene | FL/FR |
| ethyl maltol | FL/FR |
| immortelle absolute | FL/FR |
| maltol | FL/FR |
| strawberry furanone | FL/FR |
chocolate |
iso | amyl phenyl acetate | FL/FR |
| cocoa oleoresin | FL/FR |
| cocoa pentenal | FL/FR |
| vanillyl ethyl ether | FL/FR |
citrus |
| bergamot oil | FL/FR |
blood | orange oil italy | FL/FR |
coconut |
gamma- | heptalactone | FL/FR |
gamma- | nonalactone (aldehyde C-18 (so-called)) | FL/FR |
gamma- | octalactone | FL/FR |
coumarinic |
| phthalide | FL/FR |
creamy |
| geranyl ethyl acetal | FR |
para- | vanillic acid | FL/FR |
para- | vanillyl alcohol | FL/FR |
fatty |
| decanol | FL/FR |
floral |
| acetophenone | FL/FR |
| allyl anthranilate | FL/FR |
alpha- | amyl cinnamaldehyde | FL/FR |
iso | amyl salicylate | FL/FR |
para- | anisaldehyde / methyl anthranilate schiff's base | FR |
| anisyl propanal / methyl anthranilate schiff's base | FR |
| benzyl acetate | FL/FR |
| benzyl alcohol | FL/FR |
| cinnamyl phenyl acetate | FL/FR |
| citronellol | FL/FR |
para- | cresyl propionaldehyde | CS |
| cyclohexyl ethyl alcohol | FL/FR |
alpha- | damascone | FL/FR |
| dihydrojasmone | FL/FR |
| dimethyl alpha-ionone | FR |
| dimethyl anthranilate | FL/FR |
| dimethyl benzyl carbinol | FL/FR |
| dimethyl benzyl carbinyl butyrate | FL/FR |
| ethyl phenyl acetate | FL/FR |
| floral pyranol | FR |
| geraniol | FL/FR |
(E)- | geranyl acetone | FL/FR |
| geranyl phenyl acetate | FL/FR |
| heliotrope absolute | FR |
| heliotrope fragrance | FR |
| heliotrope specialty | FR |
| heliotropin replacer | |
| heliotropyl acetate | FL/FR |
| heliotropyl acetone | FL/FR |
| heliotropyl diethyl acetal | FR |
alpha- | hexyl cinnamaldehyde | FL/FR |
| hyacinth ether | FR |
| hydroxycitronellal | FL/FR |
(E)-beta- | ionone | FL/FR |
alpha- | irone | FL/FR |
| linalool oxide | FL/FR |
para- | methyl acetophenone | FL/FR |
| methyl dihydrojasmonate | FL/FR |
beta-iso | methyl ionone | FL/FR |
alpha-iso | methyl ionone (50% min.) | FL/FR |
alpha-iso | methyl ionone (90% min.) | FL/FR |
| methyl ionyl acetate | FL/FR |
| mimosa heptanal | FR |
| neroli oil bigarde | FL/FR |
| nerolidol | FL/FR |
| orris pyridine 25% IPM | FR |
| orris rhizome resinoid (iris pallida) | FL/FR |
| peony alcohol | FR |
| phenethyl alcohol | FL/FR |
| phenethyl phenyl acetate | FL/FR |
4- | phenyl-2-butanol | FL/FR |
iso | propyl phenyl acetate | FL/FR |
| rhodinol | FL/FR |
| rhodinyl phenyl acetate | FL/FR |
| rose absolute (rosa damascena) bulgaria | FL/FR |
| rose butanoate | FL/FR |
(E)-2,5,9- | trimethyl-4,9-decadien-1-al | FR |
| tuberose absolute (from pommade) | FL/FR |
fresh |
10- | undecen-1-yl acetate | FL/FR |
fruity |
| acetyl methyl anthranilate | FL/FR |
bitter | almond oil | FL/FR |
| benzaldehyde | FL/FR |
| benzaldehyde glycrol acetal | FL/FR |
| bread thiophene | FL/FR |
| cherry oxyacetate | FL/FR |
| cinnamyl isobutyrate | FL/FR |
beta- | damascone | FL/FR |
gamma- | decalactone | FL/FR |
| ethyl methyl-para-tolyl glycidate | FL/FR |
| heliotropyl isobutyrate | FL/FR |
| hexyl isovalerate | FL/FR |
| peach pivalate | FR |
| prenyl acetate | FL/FR |
| prunus amygdalus amara seed extract | FL/FR |
| tolualdehydes (mixed o,m,p) | FL/FR |
gamma- | undecalactone (aldehyde C-14 (so-called)) | FL/FR |
green |
| benzaldehyde dimethyl acetal | FL/FR |
(Z)-3- | hexen-1-yl acetate | FL/FR |
(Z)-3- | hexen-1-yl butyrate | FL/FR |
(Z)-3- | hexen-1-yl propionate | FL/FR |
(E)-2- | hexen-1-yl propionate | FL/FR |
para- | methyl hydratropaldehyde | FL/FR |
| phenoxyethyl isobutyrate | FL/FR |
3- | phenyl propionaldehyde | FL/FR |
hay |
| beeswax absolute | FL/FR |
| hay absolute | FR |
herbal |
| clary sage oil france | FL/FR |
| lavender absolute bulgaria | FL/FR |
honey |
| phenyl acetic acid | FL/FR |
medicinal |
2- | hydroxybenzaldehyde | FL/FR |
melon |
| watermelon ketone | FR |
mossy |
| veramoss (IFF) | FR |
musk |
| cyclohexadecanone | FR |
| ethylene brassylate | FL/FR |
| exaltone (Firmenich) | FR |
3- | methyl-6-cyclohexadecen-1-one | FR |
dextro,laevo- | muscone | FL/FR |
| musk amberol | FR |
| musk indane | FR |
| musk tetralin | FL/FR |
omega- | pentadecalactone | FL/FR |
musty |
| cocoa butenal | FL/FR |
naphthyl |
2,4- | dimethyl benzaldehyde | FL/FR |
para- | methyl anisole | FL/FR |
beta- | naphthyl ethyl ether | FL/FR |
nutty |
2,3,5- | trimethyl pyrazine | FL/FR |
phenolic |
| methyl benzoate | FL/FR |
powdery |
para- | anisyl acetate | FL/FR |
para- | anisyl alcohol | FL/FR |
| applelide (IFF) | FR |
alpha- | methyl ionone | FL/FR |
smoky |
2,6- | dimethoxyphenol | FL/FR |
| allspice oil | FL/FR |
| amyl isoeugenol | FR |
para- | anisyl formate | FL/FR |
| benzyl isoeugenol | FL/FR |
| cassia bark oil china | FL/FR |
| cinnamon bark oil (cinnamomum zeylanicum) india | FL/FR |
| clove bud oil | FL/FR |
| elettaria cardamomum seed oil | FL/FR |
iso | eugenyl acetate | FL/FR |
ortho- | methoxycinnamaldehyde | FL/FR |
alpha- | methyl cinnamaldehyde | FL/FR |
4- | methyl guaiacol | FL/FR |
| methyl isoeugenol | FL/FR |
black | poplar bud absolute | FR |
sweet |
| vanilla oleoresin bali | FL/FR |
terpenic |
| frankincense oil | FL/FR |
alpha- | terpineol | FL/FR |
tonka |
| coumarin | FR |
| deertongue absolute | FR |
gamma- | hexalactone | FL/FR |
| mint lactone | FL/FR |
| tonka bean absolute | FR |
vanilla |
ortho- | dimethyl hydroquinone | FL/FR |
| ethyl vanillin | FL/FR |
| ethyl vanillin hexylene glycol acetal | FR |
| ethyl vanillin isobutyrate | FL/FR |
| ethyl vanillin propylene glycol acetal | FL/FR |
| heliotropyl alcohol | FL/FR |
| vanilla bean absolute (vanilla planifolia) | FL/FR |
| vanillin | FL/FR |
| vanillyl acetate | FL/FR |
| vanillyl isobutyrate | FL/FR |
| vanillylidene acetone | FL/FR |
waxy |
| decyl acetate | FL/FR |
1- | dodecanol | FL/FR |
woody |
| amber formate | FR |
| anthocephalus cadamba oil | FR |
| guaiacwood oil | FL/FR |
| gurjun balsam oil | FR |
| patchouli ethanone | FR |
| patchouli oil | FL/FR |
| santall | FR |
(+)-alpha- | santalyl acetate | FL/FR |
| timber propanol | FR |
| tobacarol (IFF) | FR |
| vetiveryl acetate | FL/FR |
| woody acetate | FR |
(Z)- | woody amylene | FR |
| woody epoxide | FR |
| woody propanol | FR |
|
For Flavor |
|
No flavor group found for these |
| allyl anthranilate | FL/FR |
| cinnamyl phenyl acetate | FL/FR |
| cistus ladaniferus resinoid | FL/FR |
ortho- | dimethyl hydroquinone | FL/FR |
| heliotropin replacer | |
| heliotropyl alcohol | FL/FR |
| methyl (E)-cinnamate | FL/FR |
beta-iso | methyl ionone | FL/FR |
(+)-alpha- | santalyl acetate | FL/FR |
| vetiveryl acetate | FL/FR |
|
beta- | damascone | FL/FR |
amber |
| ambrette seed oil | FL/FR |
| musk tetralin | FL/FR |
animal |
| indole | FL/FR |
anise |
| anise seed oil colombia | FL/FR |
anisic |
para- | acetanisole | FL/FR |
ortho- | anisaldehyde | FL/FR |
balsamic |
sumatra | benzoin resin | FL/FR |
siam | benzoin resinoid | FL/FR |
sumatra | benzoin resinoid | FL/FR |
| benzyl salicylate | FL/FR |
iso | butyl cinnamate | FL/FR |
| copaiba balsam oil | FL/FR |
| ethyl cinnamate | FL/FR |
| myrrh oil | FL/FR |
| peru balsam oil | FL/FR |
iso | propyl cinnamate | FL/FR |
| tolu balsam | FL/FR |
| tolu balsam oil | FL/FR |
| vanillylidene acetone | FL/FR |
berry |
| heliotropyl acetone | FL/FR |
| raspberry ketone | FL/FR |
brown |
| beeswax absolute | FL/FR |
caramellic |
| caramel furanone | FL |
| cyclotene | FL/FR |
| ethyl maltol | FL/FR |
| maltol | FL/FR |
| strawberry furanone | FL/FR |
chocolate |
| cocoa oleoresin | FL/FR |
citrus |
| bergamot oil | FL/FR |
blood | orange oil italy | FL/FR |
alpha- | terpineol | FL/FR |
coconut |
6- | methyl coumarin | FL |
gamma- | nonalactone (aldehyde C-18 (so-called)) | FL/FR |
coumarinic |
| phthalide | FL/FR |
creamy |
para- | anisaldehyde | FL/FR |
gamma- | hexalactone | FL/FR |
para- | methyl acetophenone | FL/FR |
| mint lactone | FL/FR |
gamma- | undecalactone (aldehyde C-14 (so-called)) | FL/FR |
para- | vanillic acid | FL/FR |
para- | vanillyl alcohol | FL/FR |
fatty |
10- | undecenal (aldehyde C-11 undecylenic) | FL/FR |
floral |
2- | acetyl-5-methyl thiophene | FL |
iso | amyl phenyl acetate | FL/FR |
| citronellol | FL/FR |
| cocoa pentenal | FL/FR |
| dihydrojasmone | FL/FR |
| dimethyl benzyl carbinyl butyrate | FL/FR |
| geraniol | FL/FR |
(E)- | geranyl acetone | FL/FR |
| geranyl phenyl acetate | FL/FR |
| heliotropyl acetate | FL/FR |
| methyl dihydrojasmonate | FL/FR |
alpha-iso | methyl ionone (50% min.) | FL/FR |
alpha-iso | methyl ionone (90% min.) | FL/FR |
| neroli oil bigarde | FL/FR |
| orris rhizome resinoid (iris pallida) | FL/FR |
| phenethyl alcohol | FL/FR |
| phenyl acetic acid | FL/FR |
4- | phenyl-2-butanol | FL/FR |
| rhodinol | FL/FR |
| rose absolute (rosa damascena) bulgaria | FL/FR |
| tuberose absolute (from pommade) | FL/FR |
fruity |
| acetyl methyl anthranilate | FL/FR |
bitter | almond oil | FL/FR |
iso | amyl benzoate | FL/FR |
para- | anisyl acetate | FL/FR |
para- | anisyl alcohol | FL/FR |
| benzaldehyde | FL/FR |
| benzaldehyde glycrol acetal | FL/FR |
| benzyl acetate | FL/FR |
| benzyl alcohol | FL/FR |
| bread thiophene | FL/FR |
iso | butyl benzoate | FL/FR |
| cherry oxyacetate | FL/FR |
| cinnamyl isobutyrate | FL/FR |
alpha- | damascone | FL/FR |
gamma- | decalactone | FL/FR |
| dimethyl anthranilate | FL/FR |
| ethyl methyl-para-tolyl glycidate | FL/FR |
| heliotropyl isobutyrate | FL/FR |
alpha- | methyl ionone | FL/FR |
| prenyl acetate | FL/FR |
| rose butanoate | FL/FR |
| tolualdehydes (mixed o,m,p) | FL/FR |
greasy |
10- | undecen-1-yl acetate | FL/FR |
green |
iso | amyl salicylate | FL/FR |
| benzaldehyde dimethyl acetal | FL/FR |
| cinnamyl alcohol | FL/FR |
| cocoa butenal | FL/FR |
| cyclohexyl ethyl alcohol | FL/FR |
(Z)-3- | hexen-1-yl acetate | FL/FR |
(Z)-3- | hexen-1-yl butyrate | FL/FR |
(E)-2- | hexen-1-yl propionate | FL/FR |
(Z)-3- | hexen-1-yl propionate | FL/FR |
| hexyl isovalerate | FL/FR |
| immortelle absolute | FL/FR |
| linalool oxide | FL/FR |
para- | methyl hydratropaldehyde | FL/FR |
| nerolidol | FL/FR |
| phenoxyethyl isobutyrate | FL/FR |
3- | phenyl propionaldehyde | FL/FR |
herbal |
| clary sage oil france | FL/FR |
| lavender absolute bulgaria | FL/FR |
honey |
| ethyl phenyl acetate | FL/FR |
| phenethyl phenyl acetate | FL/FR |
iso | propyl phenyl acetate | FL/FR |
lactonic |
gamma- | heptalactone | FL/FR |
gamma- | octalactone | FL/FR |
meaty |
ortho- | thioguaiacol | FL |
medicinal |
2,6- | dimethoxyphenol | FL/FR |
| dimethyl benzyl carbinol | FL/FR |
musk |
| ethylene brassylate | FL/FR |
dextro,laevo- | muscone | FL/FR |
musty |
2,3,5- | trimethyl pyrazine | FL/FR |
naphthyl |
2,4- | dimethyl benzaldehyde | FL/FR |
para- | methyl anisole | FL/FR |
nutty |
2- | acetyl furan | FL/FR |
| prunus amygdalus amara seed extract | FL/FR |
phenolic |
| methyl benzoate | FL/FR |
powdery |
ortho- | acetanisole | FL/FR |
| acetophenone | FL/FR |
beta- | naphthyl ethyl ether | FL/FR |
| powdery ketone | FL |
rummy |
| vanillyl ethyl ether | FL/FR |
soapy |
| dodecanal (aldehyde C-12 lauric) | FL/FR |
1- | dodecanol | FL/FR |
spicy |
| allspice oil | FL/FR |
para- | anisyl formate | FL/FR |
| benzyl cinnamate | FL/FR |
| benzyl isoeugenol | FL/FR |
| cassia bark oil china | FL/FR |
| cinnamon bark oil (cinnamomum zeylanicum) india | FL/FR |
| cinnamyl cinnamate | FL/FR |
| clove bud oil | FL/FR |
| elettaria cardamomum seed oil | FL/FR |
iso | eugenyl acetate | FL/FR |
2- | hydroxybenzaldehyde | FL/FR |
ortho- | methoxycinnamaldehyde | FL/FR |
alpha- | methyl cinnamaldehyde | FL/FR |
| methyl cinnamate | FL/FR |
4- | methyl guaiacol | FL/FR |
| methyl isoeugenol | FL/FR |
3- | phenyl propyl alcohol | FL/FR |
chai | vanilla flavor | FL |
sweet |
| cyclohexyl acetic acid | FL/FR |
| vanilla oleoresin bali | FL/FR |
tropical |
alpha- | amyl cinnamaldehyde | FL/FR |
vanilla |
vanilla | chai flavor | FL |
| ethyl vanillin | FL/FR |
| ethyl vanillin isobutyrate | FL/FR |
| ethyl vanillin propylene glycol acetal | FL/FR |
omega- | pentadecalactone | FL/FR |
| vanilla bean absolute (vanilla planifolia) | FL/FR |
| vanillin | FL/FR |
| vanillyl acetate | FL/FR |
| vanillyl isobutyrate | FL/FR |
waxy |
| decanal (aldehyde C-10) | FL/FR |
| decanol | FL/FR |
| decyl acetate | FL/FR |
alpha- | hexyl cinnamaldehyde | FL/FR |
| hydroxycitronellal | FL/FR |
| rhodinyl phenyl acetate | FL/FR |
woody |
| amyris wood oil | FL/FR |
| frankincense oil | FL/FR |
| guaiacwood oil | FL/FR |
(E)-beta- | ionone | FL/FR |
alpha- | irone | FL/FR |
| methyl ionyl acetate | FL/FR |
| patchouli oil | FL/FR |
|
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| benzo[1,3]dioxole-5-carbaldehyde | | benzo[d][1,3]dioxole-5-carbaldehyde | 2H- | benzo[d]1,3-dioxolene-5-carbaldehyde | 1,3- | benzodioxole-5-carbaldehyde | 2H-1,3- | benzodioxole-5-carbaldehyde | 1,3- | benzodioxole-5-carboxaldehyde | 3,4- | dihydroxybenzaldehyde methylene ketal | 3,4- | dimethylene dioxybenzaldehyde | | dioxymethylene procatechuic aldehyde | | dioxymethylene protocatechuic aldehyde | | formaldehyde protechualdehyde-3,4-cyclic acetal | 5- | formyl-1,3-benzodioxole | | geliotropin | | heliobase | | heliotropin natural | | heliotropin recrystallized extra FCC | | heliotropine | | heliotropine crystals | | heliotropine crystals FCC | | heliotropine natural | | heliotropine synthetic | 3,4- | methylene dioxy) benzaldehyde | 3,4-bis( | methylene dioxy) benzaldehyde | 3,4-( | methylene dioxy)-1,3-benzodioxole-5-benzaldehyde | 3,4- | methylene dioxybenzaldehyde | 3,4- | methylene protocatechuic aldehyde | 3,4-( | methylenedioxy)benzaldehyde | 3,4- | methylenedioxybenzaldehyde | | piperonal | | piperonal nat. | | piperonaldehyde | | piperonyl aldehyde | | piperonylaldehyde | | protocatechuic aldehyde methylene ether |
Articles:
Google Patents: | Process for preparing piperonal |
PubMed: | Can head louse repellents really work? Field studies of piperonal 2% spray. |
J-Stage: | First Total Synthesis of Justicidone, a p-Quinone-Lignan Derivative from Justicia hyssopifolia |
PubMed: | Piperonal prevents high-fat diet-induced hepatic steatosis and insulin resistance in mice via activation of adiponectin/AMPK pathway. |
J-Stage: | Synthesis of Optically Active Olivil Type of Lignan from L-Arabinose Using threo-Selective Aldol Condensation as a Key Reaction |
PubMed: | Forensic profiling of sassafras oils based on comprehensive two-dimensional gas chromatography. |
PubMed: | Anticancer activity and biophysical reactivity of copper complexes of 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-alkylhydrazinecarbothioamides. |
PubMed: | Enantiomeric HPLC resolution and absolute stereochemistry assignment of a new poligamain derivative. |
PubMed: | Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli. |
PubMed: | Synthesis and impurity profiling of MDMA prepared from commonly available starting materials. |
PubMed: | Synthesis and GC-MS analysis of a series of homologs and regioisomers of 3,4-methylenedioxypyrovalerone (MDPV). |
PubMed: | Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells. |
PubMed: | Selective recognition of sesamol using molecularly imprinted polymers containing magnetic wollastonite. |
PubMed: | Simultaneous determination of bioactive compounds in Piper nigrum L. and a species comparison study using HPLC-PDA. |
PubMed: | Availability of target odor compounds from seized ecstasy tablets for canine detection. |
PubMed: | Half-sandwich ruthenium–arene complexes with thiosemicarbazones: synthesis and biological evaluation of [(η⁶-p-cymene)Ru(piperonal thiosemicarbazones)Cl]Cl complexes. |
PubMed: | Synthesis and characterization of mixed-ligand diimine-piperonal thiosemicarbazone complexes of ruthenium(II): Biophysical investigations and biological evaluation as anticancer and antibacterial agents. |
PubMed: | S-selective hydroxynitrile lyase from a plant Baliospermum montanum: molecular characterization of recombinant enzyme. |
PubMed: | Total synthesis of (+)-virgatusin via AlCl3-catalyzed [3+2] cycloaddition. |
PubMed: | In vitro biological studies and structural elucidation of fluoro-substituted phenyl acrylic acids. |
PubMed: | Enhancement in sample collection for the detection of MDMA using a novel planar SPME (PSPME) device coupled to ion mobility spectrometry (IMS). |
PubMed: | Toxicological methods for tracing drug abuse: chromatographic, spectroscopic and biological characterisation of ecstasy derivatives. |
PubMed: | Dynamic planar solid phase microextraction-ion mobility spectrometry for rapid field air sampling and analysis of illicit drugs and explosives. |
PubMed: | Detection of piperonal emitted from polymer controlled odor mimic permeation systems utilizing Canis familiaris and solid phase microextraction-ion mobility spectrometry. |
PubMed: | N-[(E)-1,3-Benzodioxol-5-yl-methyl-idene]-4-methyl-aniline. |
PubMed: | Titanium imido complexes utilizing orthometallated derivatized acetophenone and piperonal imine ligands: synthesis, isolation, and characterization. |
PubMed: | A combined experimental and theoretical study of the polar [3 + 2] cycloaddition of electrophilically activated carbonyl ylides with aldehydes and imines. |
PubMed: | Adsorbed resin phase spectrophotometric determination of vanillin or/and its derivatives. |
PubMed: | [Synthesis of pyridine-containing diacylhydrazones and study on their spectral properties]. |
PubMed: | Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity. |
PubMed: | Headspace sampling and detection of cocaine, MDMA, and marijuana via volatile markers in the presence of potential interferences by solid phase microextraction-ion mobility spectrometry (SPME-IMS). |
PubMed: | Synthesis and use of 4-peptidylhydrazido-N-hexyl-1,8-naphthalimides as fluorogenic histochemical substrates for dipeptidyl peptidase IV and tripeptidyl peptidase I. |
PubMed: | Silenes in organic synthesis: a concise synthesis of (+/-) -epi-picropodophyllin. |
PubMed: | Electrochemical and spectroscopic characterisation of amphetamine-like drugs: application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors. |
PubMed: | Alpha-phenyl-N-tert-butyl nitrone (PBN) derivatives: synthesis and protective action against microvascular damages induced by ischemia/reperfusion. |
PubMed: | Development and validation of an RP-HPLC method for quantitative determination of vanillin and related phenolic compounds in Vanilla planifolia. |
PubMed: | The fumigant and repellent activity of aliphatic lactones against Pediculus humanus capitis (Anoplura: Pediculidae). |
PubMed: | Synthesis of 7-deoxypancratistatin from carbohydrates by the use of olefin metathesis. |
PubMed: | A study of impurities in intermediates and 3,4-methylenedioxymethamphetamine (MDMA) samples produced via reductive amination routes. |
PubMed: | First total synthesis of justicidone, a p-quinone-lignan derivative from Justicia hyssopifolia. |
PubMed: | Determination of synthesis method of ecstasy based on the basic impurities. |
PubMed: | Chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets seized in Hong Kong. |
PubMed: | [Succivil efficacy in endogenous intoxication]. |
PubMed: | [Study on the spectrophotometric determination of vanadium with piperonal fluorone by atomic absorption spectrophotometer]. |
PubMed: | [Study on the determination of iron by silica gel H phase-diffuse reflectance spectrometry]. |
PubMed: | Bhc-diol as a photolabile protecting group for aldehydes and ketones. |
PubMed: | Microbiologic oxidation of isosafrole into piperonal. |
PubMed: | Concentrations of nine alkenylbenzenes, coumarin, piperonal and pulegone in Indian bidi cigarette tobacco. |
PubMed: | [Comparative evaluation of antioxidant properties of neoselen and berberin in chronic heliotrinal hepatitis]. |
PubMed: | [Morphological features of the thymus in heliotrin hepatitis upon administration of immunostimulators]. |
PubMed: | A short synthesis of (+/-)-epiasarinin. |
PubMed: | Antioxidant properties of 8.0.4'-neolignans. |
PubMed: | Asymmetric Synthesis of Sesaminone: Confirmation of Its Structure and Determination of Its Absolute Configuration. |
PubMed: | Synthesis of optically active olivil type of lignan from L-arabinose using threo-selective aldol condensation as a key reaction. |
PubMed: | Histochemical method for dipeptidyl aminopeptidase II with a new anthraquinonyl hydrazide substrate. |
PubMed: | [The effect of perftoran on the biochemical detoxication parameters in rats with an acute toxic lesion of the liver]. |
PubMed: | Enzyme-assisted asymmetric total synthesis of (-)-podophyllotoxin and (-)-picropodophyllin. |
PubMed: | Quantitation of flavor-related alkenylbenzenes in tobacco smoke particulate by selected ion monitoring gas chromatography-mass spectrometry. |
PubMed: | [The effect of immunomudulin on the structural-functional status of the organs of the immune and hematopoietic systems in chronic toxic hepatitis]. |
PubMed: | Solid phase microextraction of alkenylbenzenes and other flavor-related compounds from tobacco for analysis by selected ion monitoring gas chromatography-mass spectrometry. |
PubMed: | Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes. |
PubMed: | Cloning, functional expression and characterization of a human olfactory receptor. |
PubMed: | An Asymmetric Synthesis of L-694,458, a Human Leukocyte Elastase Inhibitor, via Novel Enzyme Resolution of beta-Lactam Esters. |
PubMed: | Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids. |
PubMed: | Synthesis, anti-GABA activity and preferred conformation of bicuculline and norbicuculline enantiomers. |
PubMed: | Fragrance administration to reduce anxiety during MR imaging. |
PubMed: | Head louse repellents. |
PubMed: | Arena tests with piperonal, a new louse repellent. |
PubMed: | New head louse repellent. |
PubMed: | [Contamination in illegal amphetamine. Contaminants resulting from the synthesis of 3,4-(methylenedioxy)amphetamine (MDA) via condensation between nitroethane and piperonal]. |
PubMed: | [Synthesis of derivatives of 2,4-bis(arylmethino)-8-butyl-8- azabicyclo[3.2.1]octan-3-one]. |
PubMed: | Determination of coumarin as an adulterant in vanilla flavoring products by high-performance liquid chromatography. |
PubMed: | Metabolic disposition of piperine in the rat. |
PubMed: | Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds. |
PubMed: | Chemosensitivity of lobster,Homarus americanus, to secondary plant compounds: Unused receptor capabilities. |
PubMed: | Metabolism of piperonal and piperonyl alcohol in the rat with special reference to the scission of the methylenedioxy group. |
PubMed: | The inhibition of rat nasal cytochrome P-450-dependent mono-oxygenase by the essence heliotropin (piperonal). |
PubMed: | Genotoxicity of safrole-related chemicals in microbial test systems. |
PubMed: | The metabolism of some food additives related to piperonal in the rabbit. |
PubMed: | Quantitative determination of chlorpromazine. HCl in tablets, spansules, injectables, and bulk chemical by nuclear magnetic resonance spectroscopy. |
PubMed: | [The mechanism of centrolobular hepatic necrosis in acute heliotropin poisoning]. |
PubMed: | [Changes in the antigenic composition of the rat liver in acute and chronic heliotropin poisoning]. |
PubMed: | [AUTOANTIGENICITY IN EXPERIMENTAL LIVER DISEASES (ANTIGENIC PROPERTIES OFTHE SERUM IN HELIOTROPIN-INDUCED HEPATITIS)]. |
PubMed: | Correlation of piperonal test values for aromatic compounds with the atmospheric concentration of benzo(A)pyrene. |
PubMed: | [ON THE SYNTHESIS OF PIPERONAL]. |
|