Name: | saussurea lappa root oil |
CAS Number: | 8023-88-9 |
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FDA UNII: | 2WF6750061 |
MDL: | MFCD01771687 |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | pale yellow solid (est) |
Food Chemicals Codex Listed: | No |
Soluble in: |
| alcohol | | water, 9.376 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Stability: |
| non-discoloring in most media |
Organoleptic Properties:
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Odor Type: animal |
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Odor Strength: | medium |
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Substantivity: | 316 hour(s) at 100.00 % |
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| orris green hairy woody melon unripe melon |
Odor Description: at 100.00 %. | orris green hairy woody unripe melons Luebke, William tgsc, (1983) |
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Flavor Type: orris |
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| costus |
Taste Description:
| costus |
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Odor and/or flavor descriptions from others (if found). |
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Firmenich |
COSTUS EO Kosher for flavor |
Odor Description: | orris green hairy woody unripe melons |
Taste Description: | Fatty metallic like herbal For creation in spirits tonalities and brown notes |
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Cosmetic Information:
Suppliers:
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | None - None found. |
S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
oral-rat LD50 3400 mg/kg Food and Cosmetics Toxicology. Vol. 12, Pg. 867, 1974.
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Dermal Toxicity: |
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 12, Pg. 867, 1974.
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavoring agents |
IFRA Critical Effect: | Dermal sensitization |
IFRA: | View Standard |
Recommendation for costus root oil usage levels up to: | | PROHIBITED: Should not be used as a fragrance ingredient.
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Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 3 |
Click here to view publication 3 |
| average usual ppm | average maximum ppm |
baked goods: | - | 1.20000 |
beverages(nonalcoholic): | - | 0.08000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 0.90000 |
fruit ices: | - | 0.90000 |
gelatins / puddings: | - | 0.10000 |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | 1.90000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| aplotaxis lappa root oil | | aucklandia costus root oil | | auklandra costus root oil | | costus oil | | costus oil 100 | | costus root oil (saussurea lappa clarke) | | saussurea costus root oil | | saussurea lappa root oil | | spiral flag root oil (saussurea lappa clarke) |
Articles:
PubMed: | UPLC/MS/MS method for quantification and cytotoxic activity of sesquiterpene lactones isolated from Saussurea lappa. |
PubMed: | Volatile constituents of Saussurea costus roots cultivated in Uttarakhand Himalayas, India. |
PubMed: | Evaluation of anti-resistant activity of Auklandia (Saussurea lappa) root against some human pathogens. |
PubMed: | Aqueous extract of Saussurea lappa root ameliorate oxidative myocardial injury induced by isoproterenol in rats. |
PubMed: | Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells. |
PubMed: | Larvicidal activity of medicinal plant extracts and lignan identified in Phryma leptostachya var. asiatica roots against housefly (Musca domestica L.). |
PubMed: | Matrix solid-phase dispersion extraction coupled with HPLC-diode array detection method for the analysis of sesquiterpene lactones in root of Saussurea lappa C.B.Clarke. |
PubMed: | Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells. |
PubMed: | A new sesquiterpene and other constituents from Saussurea lappa root. |
PubMed: | Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysaccharide-induced hepatitis in mice. |
PubMed: | Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. |
PubMed: | Authentication of Saussurea lappa, an endangered medicinal material, by ITS DNA and 5S rRNA sequencing. |
PubMed: | Effects of Saussurea lappa roots extract in ethanol on leukocyte phagocytic activity, lymphocyte proliferation and interferon-gamma (IFN-gamma). |
PubMed: | Presence of cholinergic and calcium antagonist constituents in Saussurea lappa explains its use in constipation and spasm. |
PubMed: | Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells. |
PubMed: | Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells. |
PubMed: | Cytotoxic sesquiterpene lactones from the root of Saussurea lappa. |
PubMed: | Germacrenes from fresh costus roots. |
PubMed: | Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release. |
PubMed: | Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in macrophage cell line. |
PubMed: | Effect of dehydrocostus lactone and costunolide from Saussurea root on the central nervous system in mice. |
PubMed: | Effect of polyols on heat inactivation of Aspergillus niger van Teighem inulinase. |
PubMed: | Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells. |
PubMed: | Saussureamines A, B, C, D, and E, new anti-ulcer principles from Chinese Saussureae Radix. |
PubMed: | Sesquiterpenoids from costum root oil (Saussurea lappa Clarke) |
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