Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless clear liquid (est) |
Assay: | 98.00 to 100.00 %
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Food Chemicals Codex Listed: | Yes |
Specific Gravity: | 0.86200 to 0.86800 @ 25.00 °C.
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Pounds per Gallon - (est).: | 7.173 to 7.223
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Refractive Index: | 1.38500 to 1.39100 @ 20.00 °C.
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Melting Point: | -88.00 to -87.00 °C. @ 760.00 mm Hg
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Boiling Point: | 112.00 to 113.00 °C. @ 760.00 mm Hg
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Boiling Point: | 40.00 to 41.00 °C. @ 50.00 mm Hg
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Acid Value: | 1.00 max. KOH/g
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Vapor Pressure: | 25.400000 mmHg @ 25.00 °C. |
Vapor Density: | 4.01 ( Air = 1 ) |
Flash Point: | 57.00 °F. TCC ( 13.89 °C. )
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logP (o/w): | 1.648 (est) |
Shelf Life: | 12.00 month(s) or longer if stored properly. |
Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
Soluble in: |
| alcohol | | water, 3172 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
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Odor Type: fruity |
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Odor Strength: | high , recommend smelling in a 10.00 % solution or less |
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Substantivity: | 4 hour(s) at 100.00 % |
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| sweet ethereal fruity alcoholic fusel rummy |
Odor Description: at 10.00 % in dipropylene glycol. | sweet ethereal fruity alcoholic fusel rummy |
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| sweet ethereal fruity pungent alcoholic fusel rummy |
Odor Description:
| Sweet, etherial and fruity with pungent, alcoholic, fusel and rummy nuances Mosciano, Gerard P&F 22, No. 2, 69, (1997) |
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Flavor Type: ethereal |
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| pungent ethereal fruity alliaceous egg nog |
Taste Description: at 12.50 ppm. | Pungent, etherial and fruity with a rum-and egg nog-like nuance Mosciano, Gerard P&F 22, No. 2, 69, (1997) |
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Odor and/or flavor descriptions from others (if found). |
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Alfrebro |
ETHYL ISOBUTYRATE NATURAL |
Odor Description: | Citrus, Buttery, Cherry, Strawberry |
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Moellhausen |
ETHYL ISOBUTYRATE |
Odor Description: | sweet, fruity, ethereal, with a rum like nuance |
Taste Description: | fruity, sweet |
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Blue Marble Biomaterials |
Ethyl Isobutyrate - Natural ≥98% |
Odor Description: | Fruity, sweet: Alcoholic: rum |
Taste Description: | Fruity, pungent: rum |
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Cosmetic Information:
Suppliers:
Advanced Biotech |
ETHYL ISOBUTYRATE NATURAL
98% min. Odor: Fruity |
Alfrebro |
ETHYL ISOBUTYRATE NATURAL
Odor: Citrus, Buttery, Cherry, Strawberry |
Ambles Nature et Chimie |
ISOBUTYRATE ETHYLE NAT
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Apple Flavor & Fragrance |
Ethyl isobutyrate
|
Astral Extracts |
Ethyl Isobutyrate
|
Augustus Oils |
Ethyl Iso Butyrate
|
Services |
Aurochemicals |
ETHYL ISOBUTYRATE, Natural
|
Axxence Aromatic |
ETHYL ISOBUTYRATE Natural
Kosher |
Sustainability |
Beijing Lys Chemicals |
Ethyl isobutyrate
|
Berjé |
Ethyl Iso Butyrate
|
Media |
Charkit Chemical |
ETHYL ISOBUTYRATE FEMA 2428
|
Elan Inc. |
ETHYL ISO BUTYRATE
(natural), Kosher |
EMD Millipore |
For experimental / research use only. |
Ethyl Isobutyrate
|
Ernesto Ventós |
ETHYL ISOBUTYRATE
Odor: FRUITY AND AROMATIC |
Excellentia International |
Ethyl Isobutyrate Natural
|
Fleurchem |
ethyl isobutyrate natural
|
Frutarom |
ETHYL ISOBUTYRATE
KOSHER Flavor: Sweet, Ethereal, Fruity, Alcoholic, Rummy |
CBD Offering |
Global Essence |
Ethyl Isobutyrate
|
Grau Aromatics |
ETHYL-iso-BUTYRATE FCC
NI, Kosher |
H. Interdonati, Inc. |
Ethyl isobutyrate Natural, Kosher
|
Featured Products |
IFF |
ETHYL ISOBUTYRATE
KOSHER Flavor: Sweet, Ethereal, Fruity, Alcoholic, Rummy |
Indenta Group |
Ethyl Isobutyrate
|
Indukern F&F |
ETHYL ISOBUTYRATE
Odor: SWEET, FRUITY, ETHEREAL |
Jiangyin Healthway |
Ethyl Isobutyrate
|
New functional food ingredients |
K.L. Koh Enterprise |
ETHYL ISOBUTYRATE
|
Lluch Essence |
ETHYL ISOBUTYRATE NATURAL
|
Lluch Essence |
ETHYL ISOBUTYRATE
|
M&U International |
ETHYL ISOBUTYRATE
|
M&U International |
NAT.ETHYL ISOBUTYRATE, Kosher
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Mane |
Ethyl Isobutyrate
Odor: Fermented Wine lees Apple |
Moellhausen |
ETHYL ISOBUTYRATE
Odor: sweet, fruity, ethereal, with a rum like nuance Flavor: fruity, sweet |
Pearlchem Corporation |
Natural Ethyl Isobutyrate
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Penta International |
ETHYL ISOBUTYRATE NATURAL
|
Penta International |
ETHYL ISOBUTYRATE
|
R C Treatt & Co Ltd |
Ethyl Isobutyrate
|
Reincke & Fichtner |
Ethyl Iso Butyrate natural
|
Reincke & Fichtner |
Ethyl Isobutyrate
|
Robertet |
ETHYL ISOBUTYRATE
Pure & Nat (EU) |
Seasons and Harvest / Crop calendar |
Seqens |
Ethyl Iso-butyrate, Kosher
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Sigma-Aldrich |
Ethyl isobutyrate, ≥98%, FCC, FG
Odor: citrus; strawberry |
Certified Food Grade Products |
Sigma-Aldrich |
Ethyl isobutyrate, natural, ≥98%, FCC, FG
Odor: citrus; strawberry |
SRS Aromatics |
ETHYL ISO BUTYRATE NATURAL
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SRS Aromatics |
ETHYL ISO BUTYRATE
|
Sunaux International |
nat.Ethyl Isobutyrate
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Taytonn ASCC |
Ethyl Isobutyrate
|
TCI AMERICA |
For experimental / research use only. |
Ethyl Isobutyrate >99.0%(GC)
|
Ungerer & Company |
Ethyl Iso Butyrate
|
Vigon International |
Ethyl Isobutyrate FCC
|
Vigon International |
Ethyl Isobutyrate Natural FCC
|
WEN International |
ETHYL ISOBUTYRATE Natural
|
WholeChem |
Ethyl isobutyrate
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Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xi - Irritant |
R 10 - Flammable. R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 24/25 - Avoid contact with skin and eyes. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Human Experience: |
8 % solution: no irritation or sensitization. |
Oral/Parenteral Toxicity: |
oral-rat LD50 > 5000 mg/kg (Moreno, 1975b)
intraperitoneal-mouse LD50 800 mg/kg Food and Cosmetics Toxicology. Vol. 16, Pg. 741, 1978.
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for ethyl isobutyrate usage levels up to: | | 8.0000 % in the fragrance concentrate.
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Maximised Survey-derived Daily Intakes (MSDI-EU): | 640.00 (μg/capita/day) |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 3 |
Click here to view publication 3 |
| average usual ppm | average maximum ppm |
baked goods: | - | 200.00000 |
beverages(nonalcoholic): | - | 10.00000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | - |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 25.00000 |
fruit ices: | - | 25.00000 |
gelatins / puddings: | - | 6.00000 |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | 73.00000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
iso | butyric acid ethyl ester | iso | butyric acid ethylester | iso | butyric acid, ethyl ester | | ethyl 2-methyl propanoate | | ethyl 2-methyl propionate | | ethyl 2-methylpropanoate | | ethyl 2-methylpropionate | | ethyl 2,2-dimethyl acetate | | ethyl 2,2-dimethylacetate | | ethyl iso butyrate | | ethyl isobutanoate | nat. | ethyl isobutyrate | | ethyl isobutyrate 99%, (naturals) | | ethyl isobutyrate FCC | | ethyl isobutyrate FCC natural | | ethyl isobutyrate natural | | ethyl isobutyrate, natural | | ethyl methylpropanoate | | ethyl-iso-butyrate FCC | | ethylisobutyrate | 2- | methyl propanoic acid ethyl ester | 2- | methyl propionic acid ethyl ester | 2- | methylpropanoic acid ethyl ester | | propanoic acid, 2-methyl ethyl ester | | propanoic acid, 2-methyl-, ethyl ester | | propionic acid, 2-methyl-, ethyl ester |
Articles:
Info: | Volatile Flavor Components in Bogyojosaeng and Suhong Cultivars of Strawberry (Fragaria ananassa Duch.) |
PubMed: | In situ Metabolic Characteristic Analysis Reveals the Key Yeast in the Spontaneous and Solid-state Fermentation Process of Chinese Light-style Liquor. |
J-Stage: | Comparative Volatile Profiles in Soy Sauce According to Inoculated Microorganisms |
PubMed: | Comparative volatile profiles in soy sauce according to inoculated microorganisms. |
J-Stage: | Recyclable Polymeric p-Acid Catalyst Effective on Mannich-Type Reaction in Water |
PubMed: | Potential aromatic compounds as markers to differentiate between Tuber melanosporum and Tuber indicum truffles. |
J-Stage: | Odor-Active Constituents in Fresh Pineapple (Ananas comosus [L.] Merr.) by Quantitative and Sensory Evaluation |
PubMed: | Influence of phenolic compounds on the sensorial perception and volatility of red wine esters in model solution: an insight at the molecular level. |
PubMed: | Poly[tri(ethylene glycol) ethyl ether methacrylate]-coated surfaces for controlled fibroblasts culturing. |
PubMed: | Airborne molds and bacteria, microbial volatile organic compounds (MVOC), plasticizers and formaldehyde in dwellings in three North European cities in relation to sick building syndrome (SBS). |
PubMed: | Characterization of the major odor-active compounds in Thai durian ( Durio zibethinus L. 'Monthong') by aroma extract dilution analysis and headspace gas chromatography-olfactometry. |
PubMed: | Identification of aroma-active compounds in Jiashi muskmelon juice by GC-O-MS and OAV calculation. |
PubMed: | Automated ARGET ATRP Accelerates Catalyst Optimization for the Synthesis of Thiol-Functionalized Polymers. |
PubMed: | Comparative metabolic profiling to investigate the contribution of O. oeni MLF starter cultures to red wine composition. |
PubMed: | Main odorants in Jura flor-sherry wines. Relative contributions of sotolon, abhexon, and theaspirane-derived compounds. |
PubMed: | Experience influences elemental and configural perception of certain binary odour mixtures in newborn rabbits. |
PubMed: | A novel attractant for Anastrepha ludens (Diptera: Tephritidae) from a Concord grape product. |
PubMed: | Proportion of odorants impacts the configural versus elemental perception of a binary blending mixture in newborn rabbits. |
PubMed: | Comparison of fermented soybean paste (Doenjang) prepared by different methods based on profiling of volatile compounds. |
PubMed: | Characterization of odor-active compounds in guava wine. |
PubMed: | Responses of Rhynchophorus ferrugineus adults to selected synthetic palm esters: electroantennographic studies and trap catches in an urban environment. |
PubMed: | Characterisation of the most odour-active compounds of bone tainted dry-cured Iberian ham. |
PubMed: | Identification of odor impact compounds of Tagetes minuta L. essential oil: comparison of two GC-olfactometry methods. |
PubMed: | Nitrogen addition influences formation of aroma compounds, volatile acidity and ethanol in nitrogen deficient media fermented by Saccharomyces cerevisiae wine strains. |
PubMed: | Examples of perceptive interactions involved in specific "red-" and "black-berry" aromas in red wines. |
PubMed: | Characterization of volatile compounds contributing to naturally occurring fruity fermented flavor in peanuts. |
PubMed: | Defining the typical aroma of sherry vinegar: sensory and chemical approach. |
PubMed: | Characterization of the key aroma compounds in an american bourbon whisky by quantitative measurements, aroma recombination, and omission studies. |
PubMed: | Synthesis, alpha 1-adrenoceptor antagonist activity, and SAR study of novel arylpiperazine derivatives of phenytoin. |
PubMed: | Characterization of the key aroma compounds in soy sauce using approaches of molecular sensory science. |
PubMed: | Comparison of the odor-active compounds in unhopped beer and beers hopped with different hop varieties. |
PubMed: | Quantification of selected aroma-active compounds in Pinot noir wines from different grape maturities. |
PubMed: | Recyclable polymeric pi-acid catalyst effective on Mannich-type reaction in water. |
PubMed: | Identification based on quantitative measurements and aroma recombination of the character impact odorants in a Bavarian Pilsner-type beer. |
PubMed: | Odor-active constituents in fresh pineapple (Ananas comosus [L.] Merr.) by quantitative and sensory evaluation. |
PubMed: | Aroma extract dilution analysis of cv. Meeker (Rubus idaeus L.) red raspberries from Oregon and Washington. |
PubMed: | Identification of fruity/fermented odorants in high-temperature-cured roasted peanuts. |
PubMed: | A study on volatile organic compounds (VOCs) produced by tropical ascomycetous yeasts. |
PubMed: | Aroma extract dilution analysis of Cv. Marion (Rubus spp. hyb) and Cv. Evergreen (R. laciniatus L.) blackberries. |
PubMed: | Chemical and sensorial aroma characterization of freshly distilled Calvados. 2. Identification of volatile compounds and key odorants. |
PubMed: | Gas-phase reactivity of the O=P(OCH3)2+ phosphonium ion with aliphatic esters in a quadrupole ion trap. Spontaneous elimination of ketenes. |
PubMed: | Evaluation of aroma differences between hand-squeezed juices from Valencia late and Navel oranges by quantitation of key odorants and flavor reconstitution experiments. |
PubMed: | Evaluation of key aroma compounds in hand-squeezed grapefruit juice (Citrus paradisi Macfayden) by quantitation and flavor reconstitution experiments. |
PubMed: | Volatile flavor components in red fermented soybean (Glycine max) curds. |
PubMed: | Comparison of the most odor-active compounds in fresh and dried hop cones (Humulus lupulus L. variety spalter select) based on GC-olfactometry and odor dilution techniques. |
PubMed: | Similarities in the aroma chemistry of Gewürztraminer variety wines and lychee (Litchi chinesis sonn.) fruit. |
PubMed: | Total Synthesis of Bafilomycin A(1). |
PubMed: | Ethyl propionate: Synergistic kairomone for african palm weevil,Rhynchophorus phoenicis L. (Coleoptera: Curculionidae). |
PubMed: | Inhibition of lipogenesis in rat brown adipose tissue by clofibrate. |
PubMed: | [Impact of odor hedonics on sensory odor intensity--physiological intensity and sensory intensity]. |
PubMed: | Enhanced peroxisomal beta-oxidation of fatty acids and glutathione metabolism in rats exposed to phenoxyacetic acids. |
PubMed: | Hypolipidemia and peroxisome proliferation induced by phenoxyacetic acid herbicides in rats. |
PubMed: | Xanthone analogues of clofibrate / Synthesis and biological evaluation as antagonists of lipolysis in vitro. |
PubMed: | The mouse as a model for evaluation of hypotriglyceridemic drugs effects of nicotinic acid, clofibrate and ethyl 2-(4-dibenzofuranyloxy)-2-methylpropionate on plasma lipoproteins. |
PubMed: | The spontaneously hyperlipidemic old rat as a model for evaluation of hypolipoproteinemic drugs. Effects of nicotinic acid, clofibrate and ethyl 2-(4-dibenzofuranyloxy)-2-methylpropionate on plasma lipoproteins. |
PubMed: | Larval osmeterial secretions of the swallowtails (Papilio). |
PubMed: | [On the uricosuric activity of etofylline clofibrate (author's transl)]. |
PubMed: | [Therapeutic experiences in the treatment of hyperlipoproteinaemia with etofylline clofibrate (author's transl)]. |
PubMed: | [Effect of etofylline clofibrate on the composition of lipoproteins in hyperlipidaemia type IIb and IV (author's transl)]. |
PubMed: | [On the effect of etofylline clofibrate on serum lipids and lipoproteins in patients with hyperlipoproteinemia of various degrees (author's transl)]. |
PubMed: | [Clinical effects and tolerance of etofylline clofibrate]. |
PubMed: | [Metabolism and pharmacokinetics of etofylline clofibrate, new antilipemic]. |
PubMed: | Effect of etofylline clofibrate on experimental thrombosis and platelet function. |
PubMed: | [Evaluation of the antilipaemic potential of etofylline clofibrate, its metabolites and clofibrate in dietary-induced hyperlipidaemia in the rat (author's transl)]. |
PubMed: | Evaluation of the hypolipaemic activity of etofylline clofibrate, a new ester of etofylline and clofibric acid, and comparison with effects of known hypolipaemic agents. |
PubMed: | Hypolipaemic activity of 1-(theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (etofylline clofibrate) and its analogues in normolipaemic rats. |
PubMed: | [Pharmacology and toxicology of etofylline clofibrate]. |
PubMed: | Biopharmaceutic evaluation of etofylline clofibrate and its drug formulation. |
PubMed: | Clofibrate-induced increase in coenzyme A concentration in rat tissues. |
PubMed: | Potential hypolipidemic agents. XVII. Synthesis and plasma lipid-lowering properties of compounds related to ethyl 2-(4-dibenzofuranyloxy)-2-methylpropionate and ethyl 2-(4-chlorophenoxy)-2-methylpropionate. |
PubMed: | 1-(Theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (ML 1024), a new hypolipemic agent. |
PubMed: | Potential hypolipidemic agents. XIV. Synthesis and plasma lipid-lowering properties of substituted biphenyls, diphenyl ethers and benzofurans related to ethyl 2-(4-dibenzofuranyloxy)-2-methylpropionate. |
PubMed: | Hypolipemic activity of clofibrate-related compounds. |
PubMed: | Increase in hepatic catalase and glycerol phosphate dehydrogenase activities on administration of clofibrate and clofenapate to the rat. |
PubMed: | Ethyl-2-(p-chlorophenoxy)-2-methylpropionate (clofibrate) in experimental fat embolism in rats. |
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