Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | white to pale yellow crystals (est) |
Assay: | 97.00 to 100.00 % sum of isomers
|
Additional Assay Information: | sum of o,m,p isomers |
Heavey Metals: | <40.00 ppm; <10.00 ppm Pb |
Halogens: | passes test for chlorinated compounds |
Food Chemicals Codex Listed: | Yes |
Melting Point: | 37.00 to 40.00 °C. @ 760.00 mm Hg
|
Boiling Point: | 152.00 to 154.00 °C. @ 26.00 mm Hg
|
Boiling Point: | 256.00 °C. @ 760.00 mm Hg
|
Congealing Point: | 33.50 °C.
|
Vapor Pressure: | 0.006000 mmHg @ 25.00 °C. |
Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
|
logP (o/w): | 1.740 |
Soluble in: |
| alcohol | | fixed oils | | propylene glycol | | water, 2474 mg/L @ 25 °C (est) | | water, 2470 mg/L @ C (exp) |
Insoluble in: |
| glycerin |
Stability: |
| non-discoloring in most media |
Similar Items: note |
meta-acetanisole |
ortho-acetanisole |
Organoleptic Properties:
|
Odor Type: anisic |
|
Odor Strength: | medium |
|
Substantivity: | 251 hour(s) at 10.00 % in dipropylene glycol |
|
| sweet hawthorn anisic powdery balsamic acacia |
Odor Description: at 100.00 %. | sweet hawthorn anisic powdery balsamic acacia Luebke, William tgsc, (1985) |
|
| sweet anisic vanilla powdery balsamic cherry maraschino cherry |
Odor Description:
| Sweet, anisic, vanilla-like, with powdery balsamic and benzaldehyde nuances Mosciano, Gerard P&F 17, No. 1, 41, (1992) |
|
|
Flavor Type: anisic |
|
| sweet anisic fruity cherry powdery vanilla |
Taste Description: at 10.00 ppm. | Sweet, anisic, fruity cherry, with powdery vanilla nuances Mosciano, Gerard P&F 17, No. 1, 41, (1992) |
|
Odor and/or flavor descriptions from others (if found). |
|
Symrise |
Acetanisole cryst. |
Odor Description: | intensive sweet, somewhat rough, hay-like with floral note, hawthorn, acacia, mimosa, similar to anisaldehyde |
Taste Description: | hay-, coumarin- and vanilla-like Useful in: vanilla, fruity red, sweet others. |
|
Sigma-Aldrich |
Acetanisole, ≥98%, FCC, FG |
Odor Description: | butter; caramel; nutty; fruity; sweet; vanilla |
Taste Description: | sweet anisic fruity cherry powdery vanilla |
|
Moellhausen |
ACETANISOLE |
Odor Description: | aromatic floral, spicy (bitter almond- and hay-like) |
Taste Description: | sweet aromatic; anisic, vanilla-like, balsamic and benzaldehyde notes |
|
Indukern F&F |
ACETANISOLE |
Odor Description: | ANISEED, SWEET, VANILLA, POWDERY |
|
Pell Wall Perfumes |
Acetanisole |
Odor Description: | Sweet, floral-hawthorn, cyclamen, anisic, powdery, balsamic, acacia Arctander describes it as “Sweet, but somewhat harsh, haylike odor with floral-animal notes. Suggestive of Hawthorne, Mimosa, Heliotrope, etc. Relatively stable in soap and under similar, mild-alkaline conditions. Used in woody-floral fragrances such as Cassie, Mimosa, Fougere, Chypre, New-Mown Hay, in herbaceous citrus types, etc.“ |
|
|
Cosmetic Information:
Suppliers:
Apple Flavor & Fragrance |
Acetanisole
|
Augustus Oils |
Acetanisole (Powdered)
|
Services |
Beijing Lys Chemicals |
Anisyl methyl ketone
|
Berjé |
Acetanisole Crystals
|
Media |
BOC Sciences |
For experimental / research use only. |
4-Acetanisole
|
Diffusions Aromatiques |
ACETANISOLE CRISTALLISE
|
EMD Millipore |
For experimental / research use only. |
4'-Methoxyacetophenone
|
Ernesto Ventós |
ACETANISOLE
Odor: INTENSIVE SWEET, ANISALDEHYDE |
Indukern F&F |
ACETANISOLE LIQUID
Odor: ANISEED, SWEET, VANILLA, POWDERY |
Indukern F&F |
ACETANISOLE
Odor: ANISEED, SWEET, VANILLA, POWDERY |
Inoue Perfumery |
4-METHOXYACETOPHENONE
|
Keva |
ACETANISOLE
|
Lluch Essence |
ACETANISOLE CRYST.
Odor: SWEET, FLORAL |
Lluch Essence |
ACETANISOLE LIQUID
Odor: ANISEED, SWEET, VANILLA |
M&U International |
ACETANISOLE, Kosher
|
Moellhausen |
ACETANISOLE
Odor: aromatic floral, spicy (bitter almond- and hay-like) Flavor: sweet aromatic; anisic, vanilla-like, balsamic and benzaldehyde notes |
Pell Wall Perfumes |
Acetanisole
Odor: Sweet, floral-hawthorn, cyclamen, anisic, powdery, balsamic, acacia Use: Arctander describes it as “Sweet, but somewhat harsh, haylike odor with floral-animal notes. Suggestive of Hawthorne, Mimosa, Heliotrope, etc. Relatively stable in soap and under similar, mild-alkaline conditions. Used in woody-floral fragrances such as Cassie, Mimosa, Fougere, Chypre, New-Mown Hay, in herbaceous citrus types, etc.“ |
Penta International |
ACETANISOLE CRYSTALS FCC
|
Penta International |
ACETANISOLE CRYSTALS
|
R C Treatt & Co Ltd |
Acetanisol
|
Reincke & Fichtner |
Acetanisole
|
Santa Cruz Biotechnology |
For experimental / research use only. |
4'-Methoxyacetophenone
|
Shanghai Vigen Fine Chemical |
Acetanisole
|
Sigma-Aldrich |
Acetanisole, ≥98%, FCC, FG
Odor: butter; caramel; nutty; fruity; sweet; vanilla |
Certified Food Grade Products |
SRS Aromatics |
ACETANISOLE
Odor: Sweet, Fruity, Nutty, Vanilla |
Symrise |
Acetanisole cryst.
Odor: intensive sweet, somewhat rough, hay-like with floral note, hawthorn, acacia, mimosa, similar to anisaldehyde Flavor: hay-, coumarin- and vanilla-like Useful in: vanilla, fruity red, sweet others. |
Synerzine |
Acetanisole
|
TCI AMERICA |
For experimental / research use only. |
4'-Methoxyacetophenone >99.0%(GC)
|
Tengzhou Xiang Yuan Aroma Chemicals |
4'-Methoxyacetophenone
|
The John D. Walsh Company |
Acetanisole Crystals
|
The Lermond Company |
ACETANISOLE CRYSTALS
|
The Perfumers Apprentice |
Acetanisole Crystals
Odor: Sweet Anise Vanilla Powdery |
Tianjin Danjun International |
Acetanisole
|
Vigon International |
Acetanisole Crystals
(para Methoxy Acetophenone) Odor: Intensive sweet, somewhat rough, hay-like with floral note, hawthorn, acacia, mimosa, similar to anisaldehyde |
WholeChem |
Anisyl methyl ketone
|
Safety Information:
Preferred SDS: View |
European information : |
Most important hazard(s): | Xn - Harmful. |
R 22 - Harmful if swallowed. R 38 - Irritating to skin. S 02 - Keep out of the reach of children. S 22 - Do not breath dust. S 37 - Wear suitable gloves. S 46 - If swallowed, seek medical advice immediately and show this container or label.
|
|
Hazards identification |
|
Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
Acute toxicity, Oral (Category 4), H302 Skin irritation (Category 2), H315
|
GHS Label elements, including precautionary statements |
|
Pictogram | |
|
Signal word | Warning |
Hazard statement(s) |
H302 - Harmful if swallowed H315 - Causes skin irritation
|
Precautionary statement(s) |
P264 - Wash skin thouroughly after handling. P270 - Do not eat, drink or smoke when using this product. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P301 + P312 - IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302 + P352 - IF ON SKIN: wash with plenty of soap and water. P330 - Rinse mouth. P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention. P362 - Take off contaminated clothing and wash before reuse. P501 - Dispose of contents/ container to an approved waste disposal plant.
|
Oral/Parenteral Toxicity: |
oral-rat LD50 1720 mg/kg (Moreno, 1973t)
oral-mouse LD50 820 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: IRRITABILITY
BEHAVIORAL: MUSCLE WEAKNESS Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(4), Pg. 86, 1985.
oral-rat LD50 1720 mg/kg Food and Cosmetics Toxicology. Vol. 12, Pg. 927, 1974.
|
Dermal Toxicity: |
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 12, Pg. 927, 1974.
|
Inhalation Toxicity: |
inhalation-human TCLo 1700 ug/m3/39W CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(4), Pg. 86, 1985.
|
Safety in Use Information:
Category: | flavor and fragrance agents |
RIFM Fragrance Material Safety Assessment: Search |
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
Recommendation for para-acetanisole usage levels up to: | | 5.0000 % in the fragrance concentrate.
|
|
Maximised Survey-derived Daily Intakes (MSDI-EU): | 130.00 (μg/capita/day) |
Maximised Survey-derived Daily Intakes (MSDI-USA): | 84.00 (μg/capita/day) |
Threshold of Concern: | 1800 (μg/person/day) |
Structure Class: | I |
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
publication number: 3 |
Click here to view publication 3 |
| average usual ppm | average maximum ppm |
baked goods: | - | 5.80000 |
beverages(nonalcoholic): | - | 2.30000 |
beverages(alcoholic): | - | - |
breakfast cereal: | - | - |
cheese: | - | - |
chewing gum: | - | 840.00000 |
condiments / relishes: | - | - |
confectionery froastings: | - | - |
egg products: | - | - |
fats / oils: | - | - |
fish products: | - | - |
frozen dairy: | - | 2.50000 |
fruit ices: | - | 2.50000 |
gelatins / puddings: | - | - |
granulated sugar: | - | - |
gravies: | - | - |
hard candy: | - | 4.60000 |
imitation dairy: | - | - |
instant coffee / tea: | - | - |
jams / jellies: | - | - |
meat products: | - | - |
milk products: | - | - |
nut products: | - | - |
other grains: | - | - |
poultry: | - | - |
processed fruits: | - | - |
processed vegetables: | - | - |
reconstituted vegetables: | - | - |
seasonings / flavors: | - | - |
snack foods: | - | - |
soft candy: | - | - |
soups: | - | - |
sugar substitutes: | - | - |
sweet sauces: | - | - |
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s): |
The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients. View pdf |
European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 16 (FGE.16): Aromatic ketones from chemical group 21 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 16, Revision 1 (FGE.16Rev1)[1]: Aromatic ketones from chemical group 21- Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 69, (FGE.69)[1] - Consideration of aromatic substituted secondary alcohols, ketones and related esters evaluated by JECFA (57th meeting) structurally related to aromatic ketones from chemical group 21 evaluated by EFSA in FGE.16 (2006) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 16, Revision 2 (FGE.16Rev2): Aromatic ketones from chemical group 21 View page or View pdf |
Safety and efficacy of aromatic ketones, secondary alcohols and related esters belonging to chemical group 21 when used as flavourings for all animal species View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 69, Revision 1 (FGE.69Rev1): consideration of aromatic substituted secondary alcohols, ketones and related esters evaluated by JECFA (57th meeting), structurally related to aromatic ketones from chemical group 21 evaluated by EFSA in FGE.16Rev2 View page or View pdf |
EPI System: | View |
AIDS Citations: | Search |
Cancer Citations: | Search |
Toxicology Citations: | Search |
EPA Substance Registry Services (TSCA): | 100-06-1 |
EPA ACToR: | Toxicology Data |
EPA Substance Registry Services (SRS): | Registry |
Laboratory Chemical Safety Summary : | 7476 |
National Institute of Allergy and Infectious Diseases: | Data |
WGK Germany: | 2 |
| 1-(4-methoxyphenyl)ethanone |
Chemidplus: | 0000100061 |
RTECS: | AM9240000 for cas# 100-06-1 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| acetanisol | | acetanisole | p- | acetanisole | | acetanisole cryst. | | acetanisole crystals | 4- | acetyl anisole | p- | acetyl anisole | para- | acetyl anisole | 4- | acetylanisole | p- | acetylanisole | para- | acetylanisole | | castoreum anisole | | ethanone, 1-(4-methoxyphenyl)- | | linarodin | para- | methoxy acetophenone | | methoxyacetophenone | 4- | methoxyacetophenone | 4'- | methoxyacetophenone | p- | methoxyacetophenone | para- | methoxyacetophenone | 4- | methoxyphenyl methyl ketone | p- | methoxyphenyl methyl ketone | para- | methoxyphenyl methyl ketone | 1-(4- | methoxyphenyl) ethanone | 1-(4- | methoxyphenyl)-ethanone | 1-(4- | methoxyphenyl)ethan-1-one | 1-(4- | methoxyphenyl)ethanon | (4- | methoxyphenyl)ethanone | 1-(4- | methoxyphenyl)ethanone | 4- | methoxyphenylmethyl ketone | p- | methoxyphenylmethyl ketone | para- | methoxyphenylmethyl ketone | | methyl 4-methoxyphenyl ketone | | methyl p-methoxyphenyl ketone | | methyl para-methoxyphenyl ketone | | novatone | | vananote |
Articles:
|